Acetyl L-carnitine HCL Powder
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What is Acetyl L-carnitine HCL?
Acetyl L-carnitine HCL (CAS 5080-50-2), also known as ALCAR or Acetyl Levocarnitine Hydrochloride, is an acetylated form of L-carnitine that plays a crucial role in cellular energy production. With a molecular formula of C9H17NO4·HCl and molecular weight of 239.7 g/mol, this compound helps transport fatty acids into mitochondria where they’re converted to energy. While not derived from botanical sources, it’s synthetically produced to match the naturally occurring compound in the human body. Provita Biotech, the leading bulk Acetyl L-carnitine HCL Powder supplier in China, provides this supplement in a white to off-white crystalline powder form with ≥99% purity. The compound features excellent bioavailability, with approximately 87% absorption rate when taken orally, making it more effective than standard L-carnitine for crossing the blood-brain barrier and delivering cognitive benefits alongside its metabolic functions.
Acetyl-L-Carnitine HCl vs Acetyl-L-Carnitine
While both compounds deliver the cognitive and metabolic benefits of acetylcarnitine, Acetyl-L-Carnitine HCl generally offers superior advantages for commercial applications. The hydrochloride salt form provides better stability, extended shelf life, higher water solubility, and more consistent bioavailability—all critical factors for supplement manufacturers. Though slightly more expensive, Acetyl-L-Carnitine HCl’s enhanced properties and reliability make it the preferred choice for quality-focused supplement producers and pharmaceutical applications where precise formulation and consistent performance are essential.
| Feature | Acetyl-L-Carnitine HCl | Acetyl-L-Carnitine |
|---|---|---|
| CAS Number | 5080-50-2 | 14992-62-2 |
| Other Names | ALCAR HCl, Acetyl Levocarnitine Hydrochloride | ALCAR, Acetyl Levocarnitine |
| Molecular Formula | C₉H₁₇NO₄·HCl | C₉H₁₇NO₄ |
| Molecular Weight | 239.7 g/mol | 203.24 g/mol |
| Appearance | White to off-white crystalline powder | White to off-white powder |
| Purity | Typically ≥99% | Typically 98-99% |
| Bioavailability | Higher and more consistent (87-90%) | Good but more variable (75-85%) |
| Potency | More potent per gram due to salt form | Standard potency |
| Half-life | 4-5 hours | 3-4 hours |
| Stability | Superior stability in various conditions | Good stability but more hygroscopic |
| Water Solubility | Highly water-soluble | Less water-soluble |
| Hygroscopicity | Less hygroscopic | More hygroscopic |
| Popularity | Preferred in pharmaceutical/premium supplements | Common in standard supplements |
| Pricing | 10-15% higher cost | Standard pricing |
| Main Benefits | Cognitive function, neuroprotection, energy metabolism, mitochondrial health | Same benefits but with less consistent delivery |
| Shelf Life | Longer (typically 3+ years) | Shorter (typically 2+ years) |
| Manufacturing Consistency | More consistent in formulations | More variable in formulations |
Acetyl L-carnitine HCL Powder COA
This Certificate of Analysis confirms that ProVita Biotech’s Acetyl-L-Carnitine HCl (Batch No. ALC231227040) exceeds quality specifications with an exceptional assay purity of 100.3% (within specification of 98.0-101.0%). Heavy metals testing shows all parameters well below regulatory limits, with lead (<3ppm), cadmium (<1ppm), mercury (<0.1ppm), and arsenic (<1ppm) all meeting USP standards, while total heavy metals measure <10ppm. Residual testing confirms minimal loss on drying (0.18%) and residue on ignition (0.05%), both significantly below the ≤0.50% threshold. Microbial analysis shows negative results for E.Coli and Salmonella, with TPC and Yeast & Mold counts below 10CFU/g. This premium-grade Acetyl-L-Carnitine HCl has been rigorously tested using USP-compliant methods and verified by independent third-party analysis, ensuring it meets international pharmaceutical standards for safety, purity, and quality.
Application
Cognitive Enhancement
Acetyl L-carnitine HCL is a premier ingredient in cognitive health supplements due to its ability to cross the blood-brain barrier effectively. Studies show it supports brain function by enhancing mitochondrial energy production in neurons and promoting acetylcholine synthesis. Supplement manufacturers incorporate this powerful compound in nootropic formulations to improve memory, mental clarity, and cognitive performance, particularly for aging populations seeking to maintain brain health.
Sports Nutrition
In the sports nutrition industry, Acetyl L-carnitine HCL serves as a key performance-enhancing ingredient. Its role in fatty acid transportation to cellular mitochondria makes it valuable for improving energy production during exercise, enhancing recovery, and supporting fat metabolism. Athletes and fitness enthusiasts use ALCAR supplements to optimize workout efficiency, reduce exercise-induced muscle damage, and potentially improve body composition when combined with proper training.
Anti-Aging
The pharmaceutical and nutraceutical sectors leverage Acetyl L-carnitine HCL in anti-aging formulations due to its potent antioxidant properties and mitochondrial support. It helps combat oxidative stress, supports cellular energy production, and maintains cellular integrity. Wellness products featuring this compound target age-related decline by supporting overall metabolic function, cardiovascular health, and maintaining vitality. Its high bioavailability makes it an efficient choice for anti-aging supplement protocols.
Acetyl L-carnitine HCL Powder Manufacturing Process
ProVita Biotech employs a sophisticated, multi-step manufacturing process to produce pharmaceutical-grade Acetyl L-Carnitine HCl powder with 99% purity that consistently passes international standards and third-party quality testing.
The manufacturing begins with S,R-epichlorohydrine as the starting material, which undergoes hydrolytic kinetic resolution to isolate the pure S-epichlorohydrine isomer, ensuring stereochemical purity essential for biological activity. The S-epichlorohydrine then undergoes a controlled chemical reaction sequence that transforms it into L-Carnitine in an aqueous sodium chloride solution.
Following this transformation, the solution undergoes a critical separation process where sodium chloride is removed, followed by precision crystallization and carefully controlled drying to yield pure L-Carnitine base. This intermediate is then acetylated through a reaction with acetyl chloride and acetic acid under strictly controlled conditions to form Acetyl L-Carnitine.
In the final purification stage, the product undergoes another separation process using ethanol as a solvent to remove sodium chloride and other impurities. This is followed by recrystallization and drying under precise temperature and humidity conditions to produce the final Acetyl L-Carnitine HCl powder. The finished product is rigorously tested according to USP methods for identification, purity, heavy metals, microbial contaminants, and physical properties, consistently achieving 99% purity with optimal particle size distribution (100% passing through 20 mesh screen) and ideal bulk density (0.4-0.7 g/ml). Each batch is certified by both in-house and independent third-party laboratories to ensure full compliance with international pharmaceutical standards before packaging in 25kg drums.
Acetyl L-carnitine HCL Benefits
Enhanced Cognitive Function: Improves memory, focus, and mental clarity by supporting neural metabolism and acetylcholine production.
Neuroprotective Properties: Guards against age-related cognitive decline and protects neural structures from oxidative damage.
Improved Mitochondrial Efficiency: Boosts cellular energy production by facilitating fatty acid transport into mitochondria.
Athletic Performance Support: Enhances exercise capacity, reduces muscle fatigue, and improves recovery times after intense workouts.
Fat Metabolism Optimization: Accelerates the conversion of fat stores into usable energy, supporting weight management efforts.
Antioxidant Protection: Combats free radicals and reduces oxidative stress at the cellular level.
Mood Enhancement: Helps regulate neurotransmitter activity, potentially reducing symptoms of depression and anxiety.
Cardiovascular Support: Improves heart muscle function and helps maintain healthy cholesterol and triglyceride levels.
Insulin Sensitivity Improvement: Enhances glucose metabolism and cellular response to insulin.
Anti-Aging Properties: Supports cellular longevity and helps maintain youthful metabolic function across body systems.
Nerve Health Maintenance: Supports peripheral nerve function and may help reduce neuropathic discomfort.
Superior Bioavailability: Crosses the blood-brain barrier more effectively than standard L-carnitine, maximizing therapeutic potential.
Where to buy Acetyl L-carnitine HCL bulk powder?
Looking for premium Acetyl L-carnitine HCL bulk powder for your supplement formulations? ProVita Biotech stands as China’s leading supplier of high-purity Acetyl L-carnitine HCL powder for manufacturers and distributors worldwide.
Our advantages include:
- Guaranteed 99%+ purity with comprehensive COA documentation
- Large-scale production capacity of 10+ metric tons monthly
- Competitive factory-direct pricing on wholesale Acetyl L-carnitine HCL
- Stringent quality control exceeding international standards
- Flexible minimum order quantities to suit diverse production needs
- Secure packaging options ensuring product stability during transit
- Reliable global logistics solutions with expedited delivery available
ProVita Biotech’s bulk Acetyl L-carnitine HCL undergoes rigorous testing for heavy metals, microbial contamination, and potency verification before shipping. Our manufacturing facility maintains ISO, GMP, and HACCP certifications, ensuring the highest quality standards.
Contact our ingredient specialists today for Acetyl L-carnitine HCL bulk powder samples, detailed specifications, and customized quotations tailored to your production requirements.
FAQs
While both support fat metabolism, Acetyl L-carnitine HCL crosses the blood-brain barrier more effectively, offering both cognitive and metabolic benefits. For weight management formulations, our Acetyl L-carnitine HCL provides enhanced bioavailability (87-90% vs 75%) and superior stability in various supplement delivery systems.
ProVita's Acetyl L-carnitine HCL offers broader benefits for sports nutrition products. While L-carnitine tartrate primarily targets muscle recovery, our Acetyl L-carnitine HCL combines recovery support with cognitive enhancement—ideal for comprehensive pre-workout and performance formulations requiring mental focus alongside physical endurance.
Both combinations offer synergistic benefits in different applications. ALCAR with NAC provides enhanced antioxidant protection and glutathione production, while ALCAR with Alpha Lipoic Acid creates a potent mitochondrial support complex. ProVita can provide stability testing data for both combinations to optimize your specific formulation requirements.
Our Acetyl L-carnitine HCL is produced through a proprietary acetylation process of L-carnitine under controlled conditions, followed by hydrochloride salt formation. This multi-stage purification process ensures 99%+ purity while minimizing residual solvents. Our facility operates under ISO 9001, GMP, and HACCP certification standards.
Our standard MOQ is 25kg for Acetyl L-carnitine HCL bulk orders. However, we offer flexible MOQ options for new clients starting at 5kg for initial testing and formulation development. Volume discounts begin at 100kg orders.
ProVita maintains ready-to-ship inventory of Acetyl L-carnitine HCL. Standard orders are typically processed within 3-5 business days. International shipping times vary by destination: 5-7 days to North America, 7-10 days to Europe, and 10-14 days to other regions. Expedited shipping options are available upon request.
Yes, our OEM/ODM division can develop complete Acetyl L-carnitine HCL formulations from concept to finished product. We offer custom blending, proprietary delivery systems, and complete packaging solutions. Our minimum production runs start at 50,000 capsules/tablets with private labeling options available.
Yes, we offer custom milling services for specialized applications requiring specific particle size distributions. Our standard mesh sizes range from 80-200 mesh, with custom micronization available for applications requiring enhanced dissolution profiles or specialized delivery systems.