Bulk Akkermansia muciniphila Powder Supplier in China
ProVita Biotech supplies non-viable Akkermansia muciniphila powder, also known as AKK, for next-generation probiotic and postbiotic formulations. Choose 200 or 400 billion TFU/g specifications, flexible bulk packaging, and dependable global supply backed by a 300-ton annual export capability.
- 200 & 400 Billion TFU/g Specifications
- Non-Viable, Pasteurized AKK Postbiotic Powder
- 300 Tons Annual Export Capability
- NSF-cGMP, BRCGS and FSSC 22000 Quality Systems
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Bulk AKK Powder
| Product Name | Bulk Akkermansia muciniphila Powder |
| Other Names | A. muciniphila Powder, A. muciniphila strain Muc, Akkermansia probiotic culture, Akkermansia lyophilized powder, Pasteurized Akkermansia muciniphila Powder, Live / Viable Lyophilized A. muciniphila Powder, Postbiotic Akkermansia Powder, Next-Generation Probiotic, Gut Barrier Probiotic, Anaerobic Gut Symbiont Powder |
| Main Specifications | ≥2.0 × 10¹¹ TFU/g and ≥4.0 × 10¹¹ TFU/g |
| Appearance/color | Grey-white to yellow powder |
| Package | 500 g, 1 kg or 5 kg aluminum-foil bags, with customized packaging available. |
| Annual Capability | 300 tons |
What is Akkermansia muciniphila?
Akkermansia muciniphila is a mucin-associated bacterium naturally present in the mucus layer of the human colon. Commonly called AKK, AKK powder, Akkermansia powder, pasteurized Akkermansia, inactivated Akkermansia muciniphila or AKK postbiotic powder, it is widely researched as a next-generation microbiome ingredient because of its relationship with intestinal barrier integrity, mucin renewal, microbiome balance, short-chain fatty-acid metabolism and host metabolic signaling. Unlike botanical extracts, AKK has no botanical source and is not extracted from a conventional food; commercial Akkermansia muciniphila powder is produced through controlled microbial fermentation. Although “Akkermansia muciniphila probiotic powder” is a common market term, the ProVita material is pasteurized and non-viable, so it is more accurately described as a postbiotic ingredient.
Because A. muciniphila is a microorganism rather than a chemically defined compound, it has no CAS number, molecular formula, molecular weight or chemical name. ProVita supplies standardized grades containing 200 billion TFU/g and 400 billion TFU/g, expressed as total A. muciniphila cells. The finished ingredient is a fine grey-white to yellow powder produced through fermentation, thermal inactivation, biomass separation, freeze-drying, milling and cell-count standardization. The AKK-specific specification does not assign a formal water-solubility value; as a microbial biomass powder, it is generally evaluated for dispersibility in the finished formulation rather than true molecular solubility. Its functional availability is also not expressed as a conventional absorption percentage: pasteurization is designed to retain relevant bacterial structures and components, including proteins such as Amuc_1100 and P9, while formulation matrix, dosage form and processing conditions can influence final performance.
ProVita Biotech is a leading bulk Akkermansia muciniphila powder supplier in China, exporting up to 300 tons of AKK powder annually for dietary supplements, functional foods, beverages and next-generation microbiome products. Standard packaging includes 500 g, 1 kg and 5 kg aluminum-foil bags, with customized bulk packaging available. In addition to supplying AKK raw ingredients, ProVita supports OEM and private-label development of Akkermansia capsules, tablets, sachets, powders and other finished supplement formats for products positioned around gut barrier support, metabolic wellness, healthy glucose metabolism, weight-management support, microbiome balance, energy metabolism and healthy aging.
Akkermansia muciniphila Powder Specifications
ProVita Biotech supplies standardized Akkermansia muciniphila powder, also known as AKK powder, for dietary supplements, functional foods, beverages, capsules, tablets, sachets and next-generation microbiome formulations. The product is a pasteurized, non-viable bacterial powder with an appearance ranging from grey-white to yellow.
Available AKK powder grades include 200 billion TFU/g, 300 billion TFU/g and 400 billion TFU/g. The 200 billion and 400 billion grades are standard specifications, while 300 billion TFU/g and other concentrations can be customized according to the customer’s formulation, dosage, packaging and order requirements.
Because the product is intentionally pasteurized and non-viable, its total A. muciniphila cell count is reported in TFU/g rather than as a viable probiotic count in CFU/g. The product specifications also include controls for moisture, aerobic plate count, coliforms, molds, yeasts, pathogens, lead and arsenic.
Akkermansia muciniphila 200 Billion TFU/g
The standard 200 billion grade contains a total Akkermansia muciniphila cell count of at least:
≥2.0 × 10¹¹ TFU/g
This grade provides flexible inclusion levels and is suitable for:
- Akkermansia capsules
- Tablets
- Sachets and stick packs
- Powdered supplement blends
- Functional beverages
- Functional foods
- Multi-ingredient microbiome formulas
The 200 billion grade is suitable when AKK represents a larger portion of the formulation or when manufacturers need additional blending flexibility.
Akkermansia muciniphila 300 Billion TFU/g
The 300 billion grade provides a target total cell count of:
≥3.0 × 10¹¹ TFU/g
This intermediate concentration offers a balance between potency and inclusion weight. It may be suitable for capsules, tablets, sachets and combination formulas where the 200 billion grade requires more space and the 400 billion grade is more concentrated than necessary.
A supplied batch Certificate of Analysis reported an actual total cell count of 3.0 × 10¹¹ TFU/g for an AKK product tested against a minimum requirement of 2.0 × 10¹¹ TFU/g.
For commercial orders, the target cell count, carrier system, batch tolerance, minimum order quantity and packaging format should be confirmed before production.
Akkermansia muciniphila 400 Billion TFU/g
The concentrated 400 billion grade contains a total Akkermansia muciniphila cell count of at least:
≥4.0 × 10¹¹ TFU/g
The higher cell density allows supplement manufacturers to deliver the required AKK count with a lower ingredient inclusion weight. It is particularly suitable for:
- Compact capsules
- Small tablets
- High-potency sachets
- Stick packs
- Multi-ingredient formulas
- Premium postbiotic products
- Formulations with limited capsule or tablet space
The supplied 400 billion specification identifies the product as a non-viable powder produced through high-density fermentation, thermal inactivation and freeze-drying technology.
Custom AKK Powder Grades
ProVita Biotech can discuss customized Akkermansia muciniphila powder specifications according to the customer’s finished product and commercial requirements.
Custom options may include:
- Total cell count per gram
- Cell count per capsule or serving
- 200, 300 or 400 billion TFU/g grades
- Other customized TFU/g concentrations
- Carrier and standardization system
- Bulk packaging size
- Private-label packaging
- OEM capsules
- OEM tablets
- Sachets and powdered supplements
- Combined microbiome formulations
Customized specifications should be confirmed through technical review, pilot formulation and finished-product stability testing.
Quality and Safety Standards
ProVita’s AKK powder technical specifications include microbiological, physical and heavy-metal controls. The supporting documentation references quality and food-safety management systems including:
- NSF-cGMP
- BRCGS
- FSSC 22000
The standard microbiological specification limits aerobic plate count to no more than 1,000 CFU/g, coliforms to no more than 10 CFU/g, and molds and yeasts to no more than 10 CFU/g. Specified pathogens must be negative.
| Specification Item | Standard |
|---|---|
| Product name | Akkermansia muciniphila Powder |
| Common name | AKK Powder |
| Product type | Pasteurized, non-viable postbiotic powder |
| Standard grade | ≥2.0 × 10¹¹ TFU/g |
| Intermediate grade | ≥3.0 × 10¹¹ TFU/g, customized |
| Concentrated grade | ≥4.0 × 10¹¹ TFU/g |
| Custom specifications | Available according to customer requirements |
| Appearance | Grey-white to yellow powder |
| Visible impurities | Free from visible impurities |
| Moisture | ≤8.0% |
| Aerobic plate count | ≤1,000 CFU/g |
| Coliforms | ≤10 CFU/g |
| Molds and yeasts | ≤10 CFU/g |
| Salmonella | Negative |
| Listeria monocytogenes | Negative |
| Staphylococcus aureus | Negative |
| Lead | ≤1.0 mg/kg |
| Arsenic | ≤0.5 mg/kg |
| Standard packaging | 500 g, 1 kg or 5 kg aluminum-foil bags |
| Customized packaging | Available upon request |
| Shelf life | 24 months |
| Storage | Store sealed in a cool, dry place away from direct sunlight |
| Quality systems | NSF-cGMP, BRCGS and FSSC 22000 |
| Applications | Capsules, tablets, sachets, powders, beverages and functional foods |
Standard packaging includes 500 g, 1 kg and 5 kg aluminum-foil bags, with customized packaging available for bulk orders. The stated shelf life is 24 months when the product is stored in a cool, dry place and protected from direct sunlight.
ProVita Biotech supports bulk AKK powder supply, custom cell-count specifications, international shipment and OEM production of Akkermansia muciniphila capsules, tablets, sachets and powdered supplements.
Pasteurized Akkermansia muciniphila vs. Live AKK
ProVita’s AKK powder is a pasteurized, non-viable form of Akkermansia muciniphila. Pasteurization inactivates the bacterial cells while aiming to preserve important cell structures, outer-membrane components and functional proteins such as Amuc_1100 and P9, also known as Amuc_1631. Unlike live AKK, pasteurized A. muciniphila does not depend on bacterial survival, reproduction or intestinal colonization after consumption. A 2019 randomized, double-blind, placebo-controlled human study published in Nature Medicine evaluated both live and pasteurized A. muciniphila in overweight or obese adults with insulin resistance. The supplied study summary reports that three months of pasteurized AKK supplementation improved insulin sensitivity by 28.62%, reduced hyperinsulinemia by 34.08% and lowered plasma total cholesterol by 8.68% compared with placebo. The supplied comparison materials also indicate that pasteurized AKK produced stronger results than the live form for several measured metabolic outcomes. However, these findings come from a proof-of-concept study and should not be interpreted as evidence that every pasteurized AKK ingredient is superior to every live strain.
For supplement manufacturers, pasteurized AKK also offers important formulation advantages. It does not require the same viability protection during blending, compression, transportation and storage, and it can be standardized by total bacterial cell count in TFU/g. This makes it suitable for capsules, tablets, sachets, powdered supplements, gummies, beverages and functional foods. ProVita’s supplied pasteurized AKK powder has a stated shelf life of 24 months when stored sealed in a cool, dry place away from direct sunlight.
| Comparison Item | Pasteurized Akkermansia muciniphila | Live Akkermansia muciniphila |
|---|---|---|
| Bacterial status | Non-viable, thermally inactivated postbiotic | Viable microorganism |
| Primary functional basis | Retained bacterial cell structures, membrane components, proteins and other bioactive components | Living bacterial activity, interaction with mucin and production of metabolites |
| Requirement for intestinal survival | Does not depend on bacterial survival or reproduction | Requires sufficient viability through manufacturing, storage and consumption |
| Cell-count measurement | Standardized by total cell count in TFU/g | Commonly standardized by viable colony count in CFU/g |
| Insulin sensitivity | Approximately 28.62% improvement compared with placebo in the supplied human study summary | Improved in the supplied comparison, but the reported effect was weaker |
| Hyperinsulinemia | Reduced by approximately 34.08% compared with placebo | Less pronounced effect in the supplied comparison |
| Plasma total cholesterol | Reduced by approximately 8.68% compared with placebo | Weaker effect in the supplied comparison |
| Broader lipid profile | Supplied comparison reports reductions in total cholesterol, LDL cholesterol and triglycerides | Effects reported as weaker |
| Body weight and fat mass | Slight reduction reported, with P = 0.09 | Weaker effect reported |
| Gut microbiome structure | Supplied materials indicate no major disruption of the overall microbiome balance | May influence microbiome composition and diversity |
| Amuc_1100 and P9 proteins | Pasteurization is designed to retain important functional bacterial components | Produced or expressed by viable bacterial cells |
| Processing stability | More flexible during blending, compression and product manufacturing | More sensitive to heat, oxygen, moisture, pressure and processing conditions |
| Storage requirements | Does not require preservation of viability; ProVita powder has a stated 24-month shelf life | Requires stricter control to maintain viable cell count through shelf life |
| Capsule and tablet use | Suitable for capsules and tablets without relying on living-cell survival | Compression, moisture and storage conditions may reduce viable count |
| Gummies and beverages | More suitable for gummies, beverages and ambient-temperature functional foods | Heat, water activity, acidity and processing may reduce viability |
| Finished-product applications | Capsules, tablets, powders, sachets, gummies, beverages and functional foods | Mainly products designed to protect and maintain bacterial viability |
| Formulation consistency | Total cell count can be standardized without monitoring colony formation | Finished-product potency depends on surviving viable cells |
| Commercial positioning | Next-generation postbiotic or pasteurized Akkermansia ingredient | Next-generation probiotic ingredient |
The comparison data supplied for this page describe pasteurized AKK as producing stronger improvements in insulin sensitivity, blood lipids and body-composition indicators than live AKK in the referenced study summary. The most practical difference for manufacturers is that pasteurized Akkermansia muciniphila combines researched bacterial components with greater processing flexibility, broader dosage-form compatibility and easier cell-count standardization.
ProVita Akkermansia muciniphila Efficacy and Safety Data
ProVita’s pasteurized Akkermansia muciniphila powder is based on the AKKBG-001 strain, originally isolated from the intestinal microbiota of a healthy individual in Kashgar, Xinjiang, China. The strain has a documented origin, standardized preservation records and a defined safety profile. Whole-genome sequencing has been completed, and the supplied genomic analysis reported no detected antibiotic-resistance genes or virulence genes. Additional strain-characterization results identify AKKBG-001 as Gram-negative, with no detected D-lactic acid, biogenic amines or hemolytic activity.
Whole-Genome Sequencing and Strain Traceability
Clear strain identity and traceability are essential for next-generation probiotic and postbiotic ingredients. AKKBG-001 is supported by documented isolation, strain preservation and whole-genome sequencing. The genetic assessment reported no detected harmful virulence genes or antibiotic-resistance genes, supporting its use as a standardized raw material for dietary supplement and functional-food development.
Strain Characterization and Safety Screening
Additional characterization of AKKBG-001 identified the strain as Gram-negative, consistent with the known characteristics of Akkermansia muciniphila. Oxidase and catalase activities were not detected, while testing also found no detectable D-lactic acid or biogenic amines. The strain showed negative hemolytic activity. These results provide supporting data for strain identification and safety assessment, particularly for supplement manufacturers evaluating microbial metabolites, allergen considerations and formulation suitability.
Preclinical Acute Toxicity Assessment
In the supplied acute toxicity study, pasteurized AKKBG-001 powder showed a median lethal dose, or LD50, greater than 21,500 mg/kg in mice. This preclinical result indicates a wide acute safety margin under the conditions of the animal study. It should be considered supporting ingredient safety data and not a substitute for finished-product toxicology, dosage evaluation or market-specific regulatory review.
Dedicated Anaerobic Fermentation
Akkermansia muciniphila is an anaerobic microorganism that requires carefully controlled cultivation conditions. ProVita uses a dedicated anaerobic fermentation system designed to support stable AKK biomass production while limiting oxygen exposure and reducing the risk of contamination.
The documented production flow includes strain inspection, seed culture, sterilized inoculation, controlled fermentation, pasteurization, centrifugal biomass harvesting, freeze-drying, milling, cell-count standardization and final packaging. Multiple inspection points are incorporated throughout the process.
High-Fidelity Pasteurization Technology
ProVita’s controlled thermal-inactivation process uses precise temperature management to produce non-viable AKK powder while aiming to preserve important bacterial structures, functional vesicles and key proteins associated with A. muciniphila activity.
The supplied technical data identify Amuc_1100 and P9, also known as Amuc_1631, as important functional proteins associated with intestinal barrier interaction and host energy-metabolism signaling. Genetic and proteomic analyses reported the presence of both proteins in AKKBG-001.
Allergen-Conscious Culture Medium
The supplied strain materials describe a protein-allergen-conscious fermentation medium that replaces mucin with a compound amino-acid nitrogen source. The process is designed without animal-derived materials, lactose or gluten, making the ingredient suitable for a wider range of supplement and functional-food formulations.
Final allergen statements should still be confirmed through current production documentation, batch records and destination-market requirements before being used on finished-product labels.
High-Specification Microbial Control
ProVita applies microbial-control standards throughout fermentation, biomass separation, pasteurization, freeze-drying, milling and packaging. The commercial AKK powder specifications include limits for aerobic plate count, coliforms, molds and yeasts, together with negative requirements for specified pathogens.
This standardized approach is designed to deliver consistent Akkermansia muciniphila cell counts, reliable powder quality and suitable microbiological control for international bulk ingredient buyers.
Key Efficacy and Safety Highlights
| Evaluation Area | ProVita AKKBG-001 Data |
|---|---|
| Strain source | Isolated from the intestinal microbiota of a healthy individual in Kashgar, Xinjiang |
| Strain identity | Documented origin and standardized preservation |
| Whole-genome sequencing | Completed |
| Antibiotic-resistance genes | Not detected in the supplied genomic analysis |
| Virulence genes | Not detected in the supplied genomic analysis |
| Gram staining | Gram-negative |
| D-lactic acid | Not detected |
| Biogenic amines | Not detected |
| Hemolytic activity | Negative |
| Acute toxicity | Mouse LD50 greater than 21,500 mg/kg |
| Fermentation method | Dedicated controlled anaerobic fermentation |
| Inactivation method | Precision-controlled thermal inactivation |
| Functional components | Amuc_1100, P9 and other retained bacterial components |
| Culture-medium positioning | No animal-derived materials, lactose or gluten, according to supplied strain materials |
| Production control | Multiple inspections from seed culture through packaging |
| Finished ingredient | Pasteurized, non-viable Akkermansia muciniphila powder |
These strain, safety and production data support the use of ProVita AKK powder in capsules, tablets, sachets, gummies, beverages and functional-food formulations. Product developers should evaluate the selected dosage, finished formulation, processing conditions, stability and regulatory status for each target market.
Application
Pasteurized Akkermansia muciniphila powder can be used in capsules, tablets, sachets, stick packs, powdered drink mixes, gummies, functional beverages, nutrition powders and functional foods. Because the AKK ingredient is non-viable, manufacturers do not need to preserve bacterial reproduction during processing or storage. This provides greater formulation flexibility than many live probiotic ingredients, although compatibility, dosage and stability should still be tested in the finished product. The supplied technical materials specifically identify capsules, gummies, beverages and ambient-temperature functional foods as suitable AKK applications.
Akkermansia Capsules and Tablets
Akkermansia muciniphila capsules and tablets are suitable for gut health, metabolic wellness and weight-management supplement formulas. Concentrated AKK powder allows manufacturers to deliver a high total cell count with a relatively low inclusion weight, leaving more formulation space for prebiotics, vitamins, minerals, EGCG and other complementary ingredients.
Gummies, Sachets and Powdered Supplements
Pasteurized AKK powder can be formulated into Akkermansia gummies, sachets, stick packs and powdered supplements. Its non-viable postbiotic format provides more processing flexibility than live probiotics, particularly in products where moisture, temperature or compression could reduce bacterial viability. Finished-product testing should confirm cell-count stability, dispersion, taste and shelf life.
Functional Beverages and Foods
Akkermansia muciniphila powder is suitable for functional beverages, nutrition powders and functional foods positioned around gut barrier support, microbiome balance and metabolic health. Potential formats include powdered drinks, liquid shots, meal-replacement products and other ambient-temperature formulations. Manufacturers should evaluate pH, water activity, sedimentation and ingredient compatibility during product development.
Akkermansia Muciniphila Manufacturing Process
ProVita Biotech manufactures pasteurized, non-viable Akkermansia muciniphila powder through a standardized process designed to maintain strain purity, total cell count and batch consistency. Multiple inspection points are applied from strain preparation through final packaging.
1. Medium Preparation and Sterilization
Purified water and approved culture-medium ingredients are weighed, prepared and sterilized. Production equipment, pipelines and air filters are also sterilized before inoculation to reduce contamination risks.
2. Seed Culture and Anaerobic Fermentation
The selected A. muciniphila strain is expanded through seed culture and inoculated into a controlled fermenter. Fermentation takes place under carefully managed anaerobic conditions to produce a high concentration of AKK bacterial biomass.
3. Pasteurization and Biomass Separation
After fermentation, the broth undergoes controlled thermal inactivation to produce pasteurized AKK. The biomass is then separated by centrifugation and concentrated into bacterial paste.
4. Freeze-Drying and Milling
The bacterial paste is treated with a prepared freeze-drying protectant and placed into sterilized trays. Freeze-drying produces a stable lyophilized cake, which is then milled into a fine, uniform Akkermansia muciniphila powder. The process document confirms that no emulsifier is added during the emulsification stage.
5. TFU Standardization, Testing and Packaging
The finished AKK powder is standardized to the required total cell count:
- 200 Billion TFU/g: ≥2.0 × 10¹¹ TFU/g
- 400 Billion TFU/g: ≥4.0 × 10¹¹ TFU/g
- Custom specifications: Available upon request
Each batch is tested for appearance, moisture, total AKK cell count, aerobic plate count, coliforms, molds, yeasts, specified pathogens, lead and arsenic. The product specifications reference NSF-cGMP, BRCGS and FSSC 22000 quality systems.
A supplied batch COA reported 3.0 × 10¹¹ TFU/g against a minimum 2.0 × 10¹¹ TFU/g requirement, with compliant microbiological and heavy-metal results. Third-party quality testing can also be arranged according to customer and destination-market requirements.
Through controlled fermentation, pasteurization, freeze-drying and TFU standardization, ProVita delivers consistent 200 and 400 Billion TFU/g Akkermansia muciniphila powder for capsules, tablets, sachets, gummies, beverages and functional-food formulations.
Akkermansia muciniphila Benefits
The researched Akkermansia muciniphila benefits focus on gut barrier integrity, metabolic health, insulin sensitivity, body-weight management, energy metabolism and microbiome balance. Pasteurized AKK is increasingly used as a next-generation postbiotic ingredient in gut health and metabolic wellness supplements.
- Supports the Gut Mucus Layer: Akkermansia muciniphila interacts with the mucus layer of the colon and supports mucin renewal, helping maintain the gut’s first protective barrier.
- Strengthens the Intestinal Barrier: AKK has been studied for its effects on tight-junction proteins, mucus-producing goblet cells and intestinal permeability, which may help limit the movement of bacteria, toxins and lipopolysaccharides across the gut wall.
- Supports Insulin Sensitivity: A 2019 human study published in Nature Medicine found that pasteurized AKK improved insulin sensitivity, reduced hyperinsulinemia and lowered total cholesterol in overweight or obese adults with insulin resistance.
- Supports Healthy Glucose and Lipid Metabolism: Akkermansia supplementation has been associated with healthier glucose regulation, insulin response and blood lipid markers, making it relevant for metabolic health formulations.
- Supports Healthy Body Weight: Higher natural Akkermansia abundance is commonly associated with healthier body composition. In zebrafish studies, live and pasteurized AKK reduced measured fat accumulation by approximately 50% and promoted fat breakdown by approximately 40%. These results are preclinical.
- Enhances Energy Metabolism: Preclinical testing reported increases in ATP levels and the NAD+/NADH ratio after AKK treatment, suggesting potential support for cellular energy production and metabolic balance.
- Protects the Gastrointestinal Mucosa: AKK samples reduced intestinal neutrophil accumulation, increased mucus-producing goblet cells and improved intestinal villus structure in zebrafish models, supporting further research into gastrointestinal barrier protection.
- Supports GLP-1-Related Signaling: The secreted protein P9, also known as Amuc_1631, has been studied for its relationship with GLP-1 signaling, glucose homeostasis and host energy metabolism.
- Provides Amuc_1100 and P9 Functional Proteins: Amuc_1100 is associated with intestinal barrier interaction, while P9 is linked to metabolic signaling. Genetic and proteomic testing detected both proteins in the AKKBG-001 strain.
- Supports a Balanced Gut Immune Response: Akkermansia interacts with immune-signaling pathways in the intestinal mucosa and may help maintain a balanced local immune response without excessive inflammation.
- Complements Traditional Probiotics: Unlike Lactobacillus and Bifidobacterium, Akkermansia is a Gram-negative, mucin-associated bacterium with a different mechanism of action. It can complement conventional probiotics in comprehensive gut microbiome formulas.
- Suitable for Next-Generation Postbiotic Products: Pasteurized AKK provides researched gut barrier, metabolic health and weight-management positioning without requiring live bacterial survival. It is suitable for capsules, tablets, powders, sachets, gummies, beverages and functional foods.
Human evidence is most established for insulin sensitivity and selected metabolic markers, while findings related to fat absorption, energy metabolism and gastrointestinal repair are primarily supported by preclinical studies.
Where to Buy Akkermansia muciniphila Powder?
ProVita Biotech Co., Ltd. is a leading bulk Akkermansia muciniphila powder supplier in China, supplying pasteurized, non-viable AKK powder for dietary supplements, functional foods, beverages and microbiome formulations. Available grades include 200 billion TFU/g and 400 billion TFU/g, with customized specifications available for qualified bulk and wholesale projects. The product is supplied as a grey-white to yellow powder with controlled microbiological limits, heavy-metal testing and a stated 24-month shelf life.
Why source AKK powder from ProVita Biotech?
- China-based AKK powder factory and supplier
- 200 and 400 billion TFU/g specifications
- Competitive bulk Akkermansia muciniphila price
- Wholesale supply for global supplement manufacturers
- OEM capsules, tablets, sachets and powder blends
- Batch COA and third-party testing support
- GMP quality control and technical documentation
- NSF-cGMP, BRCGS and FSSC 22000 quality systems
- Flexible 500 g, 1 kg and 5 kg aluminum-foil packaging
- Sample availability for qualified formulation projects
- Custom specifications and private-label services
A supplied batch COA reported 3.0 × 10¹¹ TFU/g against a minimum 2.0 × 10¹¹ TFU/g requirement, with compliant moisture, microbiological and heavy-metal results.
Contact ProVita Biotech for the latest bulk Akkermansia muciniphila powder price, MOQ, free sample availability, specifications, certificates, lead time and international shipping. Kosher and Halal documentation should be confirmed with our sales team for the selected grade and production batch.
FAQs
Akkermansia muciniphila powder, commonly called AKK powder, is a microbiome ingredient produced from A. muciniphila, a bacterium naturally associated with the intestinal mucus layer. ProVita supplies a pasteurized, non-viable form for dietary supplements, functional foods, beverages and postbiotic formulations.
ProVita’s current AKK powder is pasteurized and non-viable. It is produced through controlled fermentation, thermal inactivation, biomass separation, freeze-drying, milling and total-cell-count standardization.
Live probiotics must remain viable through manufacturing, storage and consumption. Pasteurized AKK does not depend on bacterial survival or reproduction. It provides greater flexibility for tablets, gummies, beverages and other formats where heat, moisture, pressure or oxygen may reduce the stability of live microorganisms.
Pasteurized AKK is more accurately described as a postbiotic ingredient, although “Akkermansia probiotic powder” remains a common market and search term.
TFU means Total Fluorescent Units and represents the total number of fluorescently detected bacterial cells under the specified flow-cytometry method. AFU means Active Fluorescent Units and represents cells classified as active or membrane-intact under the selected staining protocol. ISO 19344 describes flow-cytometry methods for measuring active and total probiotic bacteria, but buyers should always confirm the exact test method, staining protocol and reporting basis with the laboratory.
ProVita’s pasteurized AKK specification is expressed in TFU/g because the product is intentionally non-viable and is standardized by total A. muciniphila cell count.
CFU measures microorganisms that can grow and form colonies under specified culture conditions. TFU measures total fluorescently detected bacterial cells using flow cytometry.
For live probiotics, CFU is commonly used to express viable count. For pasteurized Akkermansia muciniphila powder, TFU is more suitable because the ingredient is intentionally inactivated.
ProVita offers:
- 200 Billion TFU/g: ≥2.0 × 10¹¹ TFU/g
- 400 Billion TFU/g: ≥4.0 × 10¹¹ TFU/g
- 300 Billion TFU/g: Available as a custom specification
- Other custom grades: Subject to technical review and order requirements
The 200 and 400 billion grades are covered by the supplied standard product specifications.
AKK powder is not normally described by chemical purity percentages such as 98% or 99%. It is a microbial biomass ingredient standardized by:
- Total A. muciniphila cell count in TFU/g
- Strain identity
- Moisture
- Microbiological limits
- Pathogen testing
- Heavy-metal limits
- Appearance and packaging integrity
Buyers should compare the TFU specification, testing method, carrier system and batch COA rather than relying on a generic purity claim.
The standard appearance is a grey-white to yellow powder that is free from visible impurities. Natural color variation within the approved range may occur between production batches.
No refrigeration is required under ProVita’s supplied storage specification. Keep the powder sealed in a cool, dry place away from direct sunlight.
The stated shelf life is 24 months under the recommended storage conditions. Cold-chain requirements may differ for live AKK products or finished formulations containing other temperature-sensitive ingredients.
The production process includes:
- Raw-material weighing and medium preparation
- Sterilization of the medium, equipment and pipelines
- Strain inspection and seed culture
- Controlled fermentation
- Pasteurization of the fermentation broth
- Centrifugal biomass harvesting
- Bacterial paste preparation
- Freeze-drying
- Milling
- TFU standardization
- Quality testing and packaging
Multiple inspection points are included throughout the process. The manufacturing document also confirms that no emulsifier is added during the emulsification treatment.
No. Akkermansia muciniphila is a microorganism rather than a chemically defined compound. It therefore has no CAS number, molecular formula or molecular weight.
Typical batch-release testing includes:
- Total AKK cell count
- Appearance
- Moisture
- Aerobic plate count
- Coliforms
- Molds and yeasts
- Salmonella
- Listeria monocytogenes
- Staphylococcus aureus
- Lead
- Arsenic
- Net content
The standard specifications require moisture of no more than 8%, aerobic plate count of no more than 1,000 CFU/g, coliforms of no more than 10 CFU/g, and molds and yeasts of no more than 10 CFU/g.
Yes. A batch-specific COA can be supplied with commercial orders. One supplied batch report recorded 3.0 × 10¹¹ TFU/g, moisture of 2.7%, low microbial counts, no detected specified pathogens, and results within the stated lead and arsenic limits.
Yes. Independent third-party testing can be arranged according to the customer’s requirements. Available test items may include:
- Total cell count
- Microbiological limits
- Pathogens
- Heavy metals
- Identity testing
- Moisture
- Customized destination-market parameters
The selected laboratory, methods, sample handling, cost and testing timeline should be agreed before testing.
The supplied product materials reference NSF-cGMP, BRCGS and FSSC 22000 quality and food-safety systems. Available project documents may include the product specification, batch COA, manufacturing flow chart, storage information and safety documentation.
Certificate scope, validity and the exact manufacturing site covered should be confirmed before placing an order.
The supplied strain materials describe a culture system designed without animal-derived materials, lactose or gluten. However, finished-product allergen claims must be supported by current manufacturing records, supplier declarations and market-specific labeling requirements.
Yes. AKK powder can be formulated into capsules and tablets for gut health, metabolic wellness and microbiome-support products. The concentrated 400 billion TFU/g grade may help reduce inclusion weight in compact capsules or complex multi-ingredient formulas.
Yes. The non-viable format provides greater formulation flexibility for gummies, powdered beverages, liquid products and functional foods. Manufacturers should still evaluate heat exposure, pH, moisture, water activity, sedimentation and finished-product stability.
ProVita supports OEM and private-label development for:
- Akkermansia capsules
- Tablets
- Sachets
- Stick packs
- Powder blends
- Gummies
- Functional beverages
- Multi-ingredient microbiome formulas
Services may include formulation support, dosage selection, packaging customization, label support and finished-product manufacturing.
Yes. ProVita can help calculate the required AKK inclusion level based on:
- Target TFU per serving
- Capsule or tablet size
- Serving weight
- Selected 200, 300 or 400 billion TFU/g grade
- Other active ingredients
- Overages and stability requirements
The final formulation should be verified through pilot production and finished-product testing.
MOQ depends on the selected TFU grade, packaging size, custom specification and destination country. Standard grades and packaging generally support lower MOQs than customized TFU concentrations or OEM finished products.
Contact ProVita with your required grade, estimated annual volume and packaging preference for the current MOQ.
Bulk AKK powder pricing depends on:
- 200, 300 or 400 billion TFU/g specification
- Order quantity
- Standard or customized grade
- Packaging format
- Testing requirements
- Certificates and documentation
- Shipping method
- Destination country
- OEM or private-label services
Request a current quotation because raw-material, testing and international freight costs can change.
Free samples may be available for qualified B2B formulation, R&D and purchasing projects. Sample quantity, courier cost, customs documentation and destination restrictions should be confirmed with ProVita’s sales team.
Please provide your company name, application, target specification and expected annual demand when requesting a sample.
Standard bulk packaging includes:
- 500 g per aluminum-foil bag
- 1 kg per aluminum-foil bag
- 5 kg per aluminum-foil bag
- Customized packaging upon request
Depending on the destination and order terms, export documentation may include:
- Commercial invoice
- Packing list
- Certificate of Analysis
- Product specification
- Certificate of origin
- Manufacturing flow chart
- Safety documentation
- Shipping documents
- Available quality certificates
Importers should confirm local registration, customs and regulatory requirements before shipment.
Akkermansia muciniphila is a mucin-associated, Gram-negative bacterium linked closely to the intestinal mucus layer. Lactobacillus and Bifidobacterium are traditional probiotic groups with different biological characteristics and formulation roles.
AKK can complement conventional probiotics in broader gut barrier, microbiome and metabolic health formulations.
ProVita Biotech is a leading bulk Akkermansia muciniphila powder supplier in China, offering:
- 200 and 400 billion TFU/g standard grades
- Custom AKK specifications
- Up to 300 tons annual export capability
- Controlled fermentation and freeze-drying
- Batch COA and third-party testing support
- Flexible bulk packaging
- OEM capsules, tablets and other dosage forms
- International shipment and documentation support
Contact ProVita for current specifications, bulk pricing, sample availability, MOQ and lead time.