Alpha Lipoic Acid Powder
Home / Products / Specialty Ingredients / Alpha Lipoic Acid Powder
What is Alpha Lipoic Acid?
Alpha Lipoic Acid (ALA) is a powerful antioxidant that plays a key role in energy production and the neutralization of free radicals in the body. Its CAS number is 107-93-7, and it is also known by other names such as Thioctic Acid and 1,2-Dithiolane-3-pentanoic Acid. The molecular formula of Alpha Lipoic Acid is C8H14O2S2, and it has a molecular weight of approximately 206.33 g/mol. ALA is naturally found in small amounts in foods such as spinach, broccoli, yeast, and organ meats, though it is also synthesized by the body. The compound appears as a yellow to light-brown crystalline powder and is highly soluble in both water and fat, making it easily absorbed by the body. Due to its unique ability to function in both water and lipid environments, Alpha Lipoic Acid is highly bioavailable and effective in fighting oxidative stress, supporting metabolic health, and improving insulin sensitivity. Provita Biotech is a leading bulk Alpha Lipoic Acid Powder supplier in China, offering premium-quality products for the nutraceutical and supplement industries.
Alpha Lipoic Acid vs r Alpha Lipoic Acid
Alpha Lipoic Acid (ALA) and R Alpha Lipoic Acid (R-ALA) are both powerful antioxidants, but they have distinct characteristics. R-ALA, the natural and bioactive form of ALA, is generally considered more potent and effective, with higher bioavailability and stability. Below is a detailed comparison to help understand their differences:
R Alpha Lipoic Acid is superior to Alpha Lipoic Acid in terms of bioavailability, potency, and stability. It is the biologically active form, making it more effective at lower doses. However, it is typically more expensive than standard Alpha Lipoic Acid, which is a mixture of R and S isomers. For those seeking optimal benefits, R-ALA is the better choice despite its higher cost.
| Feature | Alpha Lipoic Acid (ALA) | R Alpha Lipoic Acid (R-ALA) |
|---|---|---|
| CAS Number | 1077-28-7 | 1200-22-2 |
| Other Names | Thioctic Acid | R-Thioctic Acid |
| Molecular Formula | C8H14O2S2 | C8H14O2S2 |
| Molecular Weight | 206.32 g/mol | 206.32 g/mol |
| Appearance | Yellow crystalline powder | Yellow crystalline powder |
| Purity | ~99% | >99% (high-purity R-isomer) |
| Bioavailability | Moderate (due to S-isomer) | High (R-isomer is bioactive) |
| Potency | Lower (mixture of R and S isomers) | Higher (pure bioactive form) |
| Half-life | Short (~30 minutes) | Longer (~1-2 hours) |
| Stability | Less stable in heat and moisture | More stable in optimized formulations |
| Popularity | Widely used due to affordability | Gaining popularity in targeted uses |
| Pricing | Affordable | More expensive (~2-3x ALA cost) |
| Functionality | General antioxidant benefits | Superior cellular and metabolic activity |
| Usage | Dietary supplements | Premium dietary supplements and research |
| Isomer Composition | 50% R-isomer + 50% S-isomer | 100% R-isomer |
Application
Antioxidant Support
Alpha Lipoic Acid is a potent antioxidant that helps neutralize free radicals, protecting cells from oxidative stress. This activity supports overall health, reduces inflammation, and can improve skin appearance by reducing fine lines and wrinkles. ALA is a popular ingredient in anti-aging skincare products due to its ability to regenerate other antioxidants like vitamins C and E.
Blood Sugar Regulation
ALA has shown promising effects in managing blood sugar levels, making it beneficial for individuals with type 2 diabetes. It enhances insulin sensitivity and helps regulate glucose metabolism, potentially reducing the risk of complications associated with high blood sugar levels. Many people use ALA supplements to support healthy blood sugar management.
Neurological Health
Due to its ability to cross the blood-brain barrier, Alpha Lipoic Acid is used to support neurological health. It has been linked to improving cognitive function, reducing symptoms of neuropathy, and protecting against age-related neurodegenerative diseases. ALA’s antioxidant properties help protect nerve cells from damage, promoting better brain health.
ALA Powder Manufacturing Process
Step 1: Hydrolytic Reaction
- Starting Material: Ethyl 6,8-dichlorocaprylate is used as the primary raw material.
- This compound undergoes a hydrolytic reaction, leading to the formation of 6,8-dichlorooctanoic acid.
Step 2: Cyclic Reaction
- The 6,8-dichlorooctanoic acid undergoes a cyclization reaction to form the core structure of Alpha Lipoic Acid (ALA).
- The cyclization reaction creates a stable sulfur-containing ring structure, a key feature of ALA.
Step 3: Decolorization
- The crude ALA is subjected to decolorization to remove impurities and improve its visual appearance.
- This step ensures the product is of high quality and meets visual and chemical standards.
Step 4: Crystal Centrifugation
- The refined material is crystallized and then centrifuged to separate pure ALA crystals from byproducts and unreacted materials.
- This step ensures purity and prepares the product for further refinement.
Step 5: Refinement
- The ALA is further refined to enhance its purity to 99%.
- Additional purification processes may include recrystallization or solvent washing to eliminate remaining impurities.
Step 6: Drying and Sieving
- The refined ALA crystals are dried and sieved to achieve the desired particle size and remove any agglomerates.
- This step ensures uniformity of the final product for its applications.
Step 7: Mixing and Packing
- The dried ALA powder is thoroughly mixed to ensure consistency and packaged under strict quality control conditions.
- Packaging is designed to protect the product from moisture, light, and other external factors that might degrade its quality.
Quality Assurance
- The final Alpha Lipoic Acid powder undergoes rigorous third-party testing to confirm its 99% purity, stability, and compliance with international standards.
- It is then certified for use in various applications, including dietary supplements, pharmaceuticals, and cosmetics.
Alpha Lipoic Acid Benefits
Alpha Lipoic Acid (ALA) is a powerful antioxidant with diverse health benefits. Here are its key advantages:
- Antioxidant Power
- Neutralizes free radicals, protecting cells from oxidative stress and damage.
- Regenerates other antioxidants like Vitamin C, Vitamin E, and glutathione.
- Supports Blood Sugar Regulation
- Enhances insulin sensitivity and helps stabilize blood glucose levels.
- Useful for managing diabetes and reducing complications like neuropathy.
- Promotes Neurological Health
- Protects nerve cells from damage caused by oxidative stress.
- May improve symptoms of peripheral neuropathy and support cognitive function.
- Anti-Aging Benefits
- Slows down aging processes by reducing oxidative damage to cells.
- Improves skin texture and reduces wrinkles by neutralizing harmful free radicals.
- Energy Production
- Plays a vital role in mitochondrial function by aiding energy production.
- Helps convert glucose into energy, boosting overall vitality.
- Cardiovascular Health
- Reduces oxidative stress on blood vessels, improving endothelial function.
- May help lower bad cholesterol (LDL) and prevent plaque buildup in arteries.
- Supports Weight Management
- Enhances metabolism and may assist in fat oxidation.
- Helps improve body composition by balancing blood sugar and reducing inflammation.
- Detoxification
- Binds to heavy metals like mercury and arsenic, promoting detoxification.
- Supports liver health by reducing oxidative damage.
- Eye Health
- Protects against oxidative stress in the eyes, potentially reducing the risk of cataracts and macular degeneration.
- Inflammation Reduction
- Reduces markers of chronic inflammation, supporting joint health and overall wellness.
Where to buy magnesium acetyl-taurate bulk powder?
If you’re searching for a reliable supplier of high-purity Alpha Lipoic Acid bulk powder, ProVita Biotech stands out as a trusted name in the industry. Here’s why ProVita Biotech is the go-to source for bulk ALA powder and what to consider when making your purchase:
Why Choose ProVita Biotech?
High Purity and Quality Assurance: ProVita Biotech provides Alpha Lipoic Acid powder with a purity level of ≥99%, ensuring its suitability for a variety of applications. Every batch undergoes rigorous testing for heavy metals, microbial limits, and other contaminants to guarantee compliance with international quality standards.
Certified Manufacturing Standards: As a leading manufacturer and supplier, ProVita Biotech adheres to GMP, ISO, and HACCP standards. This ensures consistent quality and safety in every shipment.
Customizable Bulk Options: ProVita Biotech offers flexible packaging solutions, including 25 kg fiber drums and sealed aluminum bags, to meet different business needs. Tailored options, such as specific particle sizes or stabilized forms, are also available.
Global Shipping Expertise: With extensive experience in international trade, ProVita Biotech ensures smooth logistics, timely delivery, and proper documentation for global buyers.
FAQs
R-Alpha Lipoic Acid (R-ALA): The natural and bioactive isomer of ALA, offering higher potency and effectiveness in managing blood sugar, oxidative stress, and energy metabolism.
Sodium R-Lipoate (Na-RALA): A stabilized salt form of R-ALA with improved solubility, bioavailability, and stability, commonly used in high-end supplements.
Potassium R-Lipoate (K-RALA): Another stabilized salt form of R-ALA, ideal for liquid formulations and pharmaceutical use.
Dihydrolipoic Acid (DHLA): The reduced form of ALA, acting as a direct antioxidant that regenerates other antioxidants like glutathione and Vitamin C.
Polymeric ALA (Poly-ALA): Offers enhanced stability and controlled release, suitable for extended-release formulations.
ALA Ethyl Ester: Provides improved lipophilicity for better cellular penetration, making it popular in skincare and lipophilic drug formulations.
Lipoamide: An amide derivative of ALA, involved in enzymatic reactions and metabolic health applications.
Lipoic Acid Conjugates: ALA combined with amino acids or peptides for targeted delivery and synergistic effects.
S-Alpha Lipoic Acid (S-ALA): The synthetic, non-bioactive isomer of ALA, often included in budget-friendly racemic formulations.
Most Popular Derivatives: R-ALA and its stabilized salts (Na-RALA, K-RALA) are the preferred choices for their superior bioavailability and stability.
ALA powder is commonly used as:
- Dietary Supplements: Added to capsules, tablets, or powders.
- Skincare Products: Incorporated into creams and serums for its anti-aging properties.
- Pharmaceuticals: Used in formulations to support diabetes management and neuropathy.
The typical dosage ranges from 300 mg to 600 mg per day for general antioxidant support. Higher doses may be used under medical supervision for specific conditions like diabetic neuropathy.
Yes, ALA may aid in weight management by improving metabolism, enhancing insulin sensitivity, and reducing inflammation. However, it works best when combined with a healthy diet and exercise.
Yes, ALA powder is typically derived from synthetic or plant-based sources, making it suitable for vegans and vegetarians. Check product labels to confirm.
High-quality Alpha Lipoic Acid powder typically has a purity of 99% or higher, ensuring its effectiveness and safety for use in supplements or other products.
Yes, the sample is free of charge. You can use your own courier account to arrange for collection, or we can ship it for you with the freight cost covered on your side. Additionally, the shipping cost will be deducted from your bulk order payment.
We generally do not have a strict Minimum Order Quantity (MOQ) requirement. Our standard packaging is 25kg per drum, making 25kg an ideal starting point. Smaller quantities, such as 10kg or other amounts, are also available, but please note that the unit cost may increase slightly for smaller orders. Feel free to contact us to discuss your specific requirements.
Yes, we have branches and warehouses in key locations worldwide: California (USA), Paris (Europe), Singapore (Asia), Shanghai (China), and Chestiville (Australia).