Bulk Calcium AKG Powder
98% Pure Calcium Alpha-Ketoglutarate (Ca-AKG) for Longevity, Wholesale price, trusted by nutraceutical brands worldwide
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What is Calcium AKG?
Calcium Alpha-Ketoglutarate (Calcium AKG or Ca-AKG) is a stable salt form of Alpha-Ketoglutaric Acid (AKG), a key compound in the Krebs cycle that supports energy production by synthesizing amino and fatty acids and generating ATP for cellular processes. Unlike unstable free AKG, Calcium-AKG offers a highly stable formula that resists degradation from heat or moisture, making it an ideal nutraceutical raw material for supplement manufacturing. This Ca-AKG longevity supplement is widely studied as an anti-aging ingredient due to its role in promoting mitochondrial energy, bone health, cellular metabolism, and healthy aging. With the molecular formula C5H6CaO5, molecular weight 184.18 g/mol, CAS No. 71686-01-6, and offered at ≥98% purity, our Calcium AKG appears as a fine white crystalline powder with good bioavailability and is securely packaged in 25kg fiber drums. Also known as Calcium Alpha-Ketoglutaric Acid, Calcium 2-Oxoglutarate, or Ca-AKG, it is a versatile bulk ingredient used in dietary supplements for longevity and wellness. ProVita Biotech is the leading bulk Calcium AKG powder supplier in China, also providing pure Alpha-Ketoglutaric Acid (AKG) and offering OEM services for finished dosage forms such as capsules, tablets, and custom blends.
Ca AKG vs AAKG
Both Calcium AKG (Ca-AKG) and Arginine AKG (AAKG) are salt forms of alpha-ketoglutaric acid (AKG) with distinct applications. AAKG has long been popular in sports nutrition for boosting nitric oxide and exercise performance, while Ca-AKG is now gaining recognition as a powerful longevity ingredient, linked to anti-aging, bone health, and cellular energy support. In the past two years, Calcium AKG has rapidly increased in popularity, especially in the longevity and nutraceutical industries, making it the preferred choice for brands focused on healthy aging and mitochondrial health.
| Feature | Calcium AKG (Ca-AKG) | Arginine AKG (AAKG) |
|---|---|---|
| CAS Number | 71686-01-6 | 194910-66-4 |
| Other Names | Calcium Alpha-Ketoglutarate, Ca-2-Oxoglutarate | L-Arginine Alpha-Ketoglutarate, Arginine 2-Oxoglutarate |
| Molecular Formula | C5H6CaO5 | C11H20N4O7 |
| Molecular Weight | ~184.18 g/mol | ~320.3 g/mol |
| Appearance | White crystalline powder | White to off-white crystalline powder |
| Food Sources | Not found in diet; synthesized | Arginine is found in meat, nuts, seeds, soy; AKG produced endogenously |
| Specifications | ≥98% purity, bulk powder | ≥98% purity, bulk powder |
| Bioavailability | Good, stable in calcium salt form | Good, but affected by digestive breakdown of arginine |
| Potency | Supports mitochondrial energy, longevity, bone health | Enhances nitric oxide, supports blood flow, muscle pump |
| Dosage (typical) | 1,000–2,000 mg/day in longevity studies | 3,000–6,000 mg/day in sports supplements |
| Half-life | Several hours (slower release due to calcium binding) | Shorter half-life, metabolized more quickly |
| Stability | Highly stable (calcium salt prevents AKG degradation) | Less stable; arginine can degrade under heat/moisture |
| Popularity | Rising fast in longevity & anti-aging supplements (2023–2025) | Established in sports nutrition for >15 years |
| Pricing (bulk) | Higher, premium ingredient (~USD \$150–400/kg depending on purity & order size) | Lower, widely available (~USD \$25–80/kg) |
| Main Benefits | Longevity, anti-aging, bone strength, mitochondrial health, metabolic support | Pre-workout pump, improved blood flow, endurance, performance recovery |
| Best For | Nutraceutical brands, anti-aging formulas, cellular health supplements | Sports nutrition brands, pre-workout supplements |
| OEM Options | Powder, capsules, tablets, blends | Powder, capsules, pre-workout blends |
Calcium AKG Certificate of Analysis(COA)
The Certificate of Analysis (COA) for ProVita Biotech’s Calcium Alpha-Ketoglutarate (Ca-AKG) 98% confirms exceptional quality and compliance with international standards. The product shows an assay purity of 99.4% (specification ≥98.0%), with controlled calcium content at 19.7%, and meets strict safety limits for heavy metals (Pb ≤2ppm, As ≤3ppm, Cd ≤2.5ppm, Hg ≤1.5ppm). Microbiological tests confirm compliance with low microbial counts, while residual solvents and contaminants remain within safe limits. The product is supplied in 25kg fiber drums with double polyethylene inner liners to ensure freshness and safety. Recommended storage is in a cool, dry, well-ventilated area, away from heat and oxidizing agents. Backed by ISO9001, ISO22000, Star-K Kosher, Halal, SGS, and third-party quality reports, ProVita Biotech ensures that every batch of bulk Calcium AKG powder meets the highest standards of purity, stability, and safety for nutraceutical manufacturers, supplement brands, and distributors worldwide.
Application
Longevity & Anti-Aging Supplements
Calcium AKG (Ca-AKG) is a trending longevity ingredient used in anti-aging formulas to support mitochondrial health, energy metabolism, and healthy cellular function. Its stability and bioavailability make it a preferred anti-aging supplement raw material for nutraceutical brands.
Bone Health & Calcium Support
As a calcium salt of alpha-ketoglutarate, Ca-AKG powder provides both metabolic support and essential calcium, making it valuable in bone health supplements for promoting strength, density, and overall skeletal wellness.
Cellular Energy & Metabolic Support
Ca-AKG bulk powder plays a critical role in the Krebs cycle, enhancing ATP production and supporting amino acid and fatty acid synthesis. This makes it ideal for nutraceutical formulations targeting energy, metabolism, and recovery.
Calcium AKG Manufacturing Process
The production of Calcium Alpha-Ketoglutarate (Ca-AKG) 99% powder at ProVita Biotech follows a carefully controlled fermentation-based process to ensure purity, stability, and compliance with international standards. The process begins with enzymatic conversion of selected substrates into Alpha-Ketoglutarate (AKG), followed by a fermentation step to enhance yield and consistency. The fermentation broth undergoes membrane filtration and centrifugal separation to remove impurities and concentrate the active compound. Through a calcification step, AKG is combined with calcium to form highly stable Calcium Alpha-Ketoglutarate. The solution is then further purified, dried, crushed, and carefully packaged into 25kg fiber drums with double polyethylene liners. The final product achieves ≥99% purity, with consistent assay results, low heavy metals, and microbiological safety. Every batch of bulk Calcium AKG powder passes strict in-house QC, third-party quality testing, and holds certifications including ISO9001, ISO22000, Kosher, Halal, and SGS reports, ensuring it meets the highest global standards for nutraceutical ingredient manufacturing.
Calcium AKG Benefits
- Longevity & anti‑aging support: Calcium AKG (Ca‑AKG) is a trending longevity supplement that supports healthy aging pathways.
- Mitochondrial energy: Fuels the Krebs cycle to support ATP production and sustained cellular energy.
- Cellular health: Promotes efficient metabolism, cellular renewal, and overall vitality.
- Bone health: Provides calcium plus AKG to support mineralization and skeletal strength.
- Metabolic balance: Supports healthy glucose and lipid metabolism for everyday performance.
- Nitrogen balance: Assists amino‑acid turnover and helps manage ammonia during intense activity.
- Oxidative stress support: Helps maintain antioxidant defenses and redox balance.
- Inflammatory balance: Supports a healthy, balanced inflammatory response.
- Formulation friendly: Highly stable calcium salt form with good bioavailability—ideal as a nutraceutical raw material for capsules, tablets, and blends.
- Stack‑ready: Complements anti‑aging ingredients like Urolithin A, Vitamin D3/K2, and collagen for comprehensive wellness formulas.
Where to buy bulk Calcium AKG Powder?
Choose ProVita Biotech Co., Ltd., the leading China factory supplier of bulk Calcium AKG powder (Ca-AKG). We offer a high quality Calcium AKG price, stable supply, GMP production, third-party testing, and full certificates (ISO, Kosher, Halal, SGS). Standard packaging is 25kg/drum with fast global wholesale delivery.
Why ProVita Biotech
- Factory-direct Ca-AKG with consistent ≥98–99% purity
- OEM options for capsules, tablets, and custom blends
- Free sample for quality evaluation
- COA and MSDS provided; compliant with major markets
Ready to source? Request a quote for bulk / wholesale Calcium AKG powder from our China facility and secure reliable quality, pricing, and service.
FAQs
We use enzymatic conversion and controlled fermentation to generate AKG, then perform calcification to form the calcium salt, followed by membrane filtration, centrifugation, drying, and milling for consistent particle size.
Standard grades are ≥98% and ≥99% by HPLC. Each batch is released with a full COA.
Yes. We can supply SGS or other accredited lab reports for assay, heavy metals, residual solvents, and microbiology upon request.
ISO9001, ISO22000, Halal, and Kosher. GMP production records and supplier qualification files are available for audits.
Usual lead time is 7 to 15 days for stocked lots and 2 to 4 weeks for custom specs. We maintain stable monthly output for long-term contracts.
Yes. We offer capsules, tablets, and custom blends. Private label and small trial runs can be arranged.
Assay by HPLC, calcium content by titration or ICP-OES, heavy metals by ICP-MS, residual solvents by GC, and full micro testing per food-grade or supplement standards.
Standard fine powder is 80 to 100 mesh. Other sizes can be milled on request to improve flowability or compression.
Ca-AKG is preferred for longevity and cellular energy support, while AAKG is often used in sports formulations for nitric oxide support. We can supply technical comparisons for formulation planning.
It works well in hard-shell capsules and direct-compression tablets when paired with standard excipients. Our team can suggest blend ratios for optimal flow and hardness.
Accelerated and real-time stability summaries can be shared under NDA. We also offer guidance on excipient choices and stacking with other actives.
For stacking, Ca-AKG pairs well with Urolithin A for mitochondrial support, Vitamin D3 and K2 for bone health, and collagen or magnesium for joint and recovery goals. We can formulate OEM capsules or tablets to your target ratios.
There is no clinical proof that Ca-AKG reverses greying. It may support cellular energy and healthy aging, but hair repigmentation claims remain unproven.
Timing varies by dose and endpoint. Customers typically evaluate energy or recovery in 2 to 4 weeks, and longevity or bone health markers over 8 to 12 weeks.
No supplement is confirmed to reverse greying. Nutrients like copper, biotin, and antioxidants support hair health, but evidence for true repigmentation is limited.
A precise half life for Ca-AKG is not firmly established in humans. In practice, brands use once or twice daily dosing based on total daily intake targets.
There is no single best option. Ca-AKG is a strong candidate for healthy aging, and many brands also consider Urolithin A, spermidine, CoQ10, or polyphenols depending on positioning and regulatory strategy.
Some users take calcium in the evening to align with bone turnover and to reduce daytime GI discomfort. Timing should consider interactions with iron and thyroid medications; advise consumers to consult healthcare professionals.