Citicoline Powder
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What is Citicoline?
Citicoline (CDP-choline or cytidine diphosphate-choline) is a nootropic compound that occurs naturally in the body and serves as an intermediate in the synthesis of phosphatidylcholine, a major constituent of brain tissue. The most popular commercial form is Citicoline Sodium (CAS: 33818-15-4), also known as Cytidine 5′-diphosphocholine sodium or CDP-choline sodium. It has a molecular formula of C14H26N4O11P2·Na and a molecular weight of 510.31 g/mol. This cognitive enhancer is found in small amounts in foods like organ meats and egg yolks, but is typically synthesized for supplemental use. High-quality Citicoline Sodium specifications include 99% purity, appearing as a white to off-white crystalline powder with excellent bioavailability (nearly 100% when taken orally, with approximately 90% absorption rate). Provita Biotech stands as the leading bulk Citicoline Sodium Powder supplier in China, providing pharmaceutical-grade material for nootropic formulations worldwide.
Citicoline Sodium vs Citicoline
Citicoline Sodium is generally considered the superior form for commercial and therapeutic applications compared to free-base Citicoline. The sodium salt form offers better stability, improved solubility, and consistent bioavailability, making it the preferred choice for pharmaceutical and supplement formulations. While they share the same core mechanism of action and benefits, Citicoline Sodium’s practical advantages in manufacturing, storage, and administration have made it the dominant form in the market, despite its slightly higher cost. Both forms ultimately deliver the same active compound to the body, but the sodium salt’s superior physical properties make it more commercially viable and reliable for consistent dosing.
| Property | Citicoline Sodium | Citicoline (Free Base) |
|---|---|---|
| CAS Number | 33818-15-4 | 987-78-0 |
| Other Names | CDP-choline sodium, Cytidine 5′-diphosphocholine sodium | CDP-choline, Cytidine diphosphate choline |
| Molecular Formula | C14H26N4O11P2·Na | C14H26N4O11P2 |
| Molecular Weight | 510.31 g/mol | 488.33 g/mol |
| Appearance | White to off-white crystalline powder | White to off-white crystalline powder |
| Purity | Typically available at 99% purity | Typically available at 98-99% purity |
| Bioavailability | Excellent (approximately 90% absorption) | Good, but potentially less consistent than sodium salt |
| Potency | Standardized and consistent | May vary slightly due to stability issues |
| Half-life | 56-71 hours | 56-71 hours |
| Stability | More stable in various conditions | Less stable, more hygroscopic |
| Solubility | Highly water-soluble | Less water-soluble than sodium salt |
| Popularity | Dominant form in market | Less common commercially |
| Pricing | Slightly higher cost | Lower cost but less widely available |
| Main Benefits | Enhanced cognition, neuroprotection, memory support | Same core benefits as sodium salt |
| Storage Requirements | Standard cool, dry conditions | More sensitive to moisture and temperature |
| Commercial Prevalence | Standard in pharmaceutical applications | Rarely used in commercial products |
| Manufacturing Ease | Easier to process | More challenging to handle in manufacturing |
| Regulatory Status | Well-established safety profile | Same basic safety profile but less regulatory history |
Phosphatidylserine vs Citicoline Sodium
Neither Phosphatidylserine (PS) nor Citicoline Sodium is universally “better” as they serve complementary roles in cognitive and neurological health. Phosphatidylserine excels at membrane maintenance, stress reduction, and supporting aging brains, while Citicoline Sodium specializes in neurotransmitter synthesis, brain energy metabolism, and recovery support. Notably, these compounds work exceptionally well together in a synergistic relationship—Citicoline provides the building blocks for acetylcholine and phospholipids, while Phosphatidylserine enhances cell membrane fluidity and neurotransmitter function. This complementary action makes them valuable partners in comprehensive nootropic formulations, with Citicoline supporting the production of phospholipids including phosphatidylserine, while PS itself enhances cell membrane receptivity and function. For optimal cognitive support, many advanced formulations incorporate both ingredients rather than choosing between them.
| Property | Phosphatidylserine (PS) | Citicoline Sodium |
|---|---|---|
| CAS Number | 51446-62-9 (most common form) | 33818-15-4 |
| Other Names | PS, Serine phospholipid | CDP-choline sodium, Cytidine 5′-diphosphocholine sodium |
| Molecular Formula | Variable (complex phospholipid) | C14H26N4O11P2·Na |
| Molecular Weight | ~800 g/mol (varies by source) | 510.31 g/mol |
| Appearance | White to off-white powder or yellowish substance | White to off-white crystalline powder |
| Purity | Typically 20-70% (in commercial products) | Typically available at 99% purity |
| Bioavailability | Moderate (10-20% for oral supplements) | Excellent (approximately 90% absorption) |
| Potency | Effective at lower doses (100-300mg daily) | Usually requires higher doses (250-1000mg daily) |
| Half-life | 1.5-2.5 hours | 56-71 hours |
| Stability | Moderately stable, sensitive to oxidation | Very stable in various conditions |
| Solubility | Lipid-soluble, limited water solubility | Highly water-soluble |
| Popularity | Well-established in cognitive health market | Growing rapidly in nootropic applications |
| Pricing | Generally more expensive per dose | More cost-effective for comparable effects |
| Main Benefits | Membrane maintenance, cognitive support, stress reduction, attention support | Neurotransmitter synthesis, neuroprotection, memory enhancement, brain energy support |
| Mechanism of Action | Directly incorporates into cell membranes, influences cell signaling | Precursor to phospholipids and acetylcholine, supports membrane integrity |
| Source | Originally bovine-derived, now mostly soy or sunflower | Synthetic, identical to endogenous compound |
| Drug Interactions | Few known interactions | Few known interactions |
| Onset of Effects | Gradual, cumulative (2-8 weeks) | More rapid (some effects within hours to days) |
| Target Population | Especially beneficial for older adults | Broader application across age groups |
| Research Depth | Extensive research history | Growing body of clinical research |
| Safety Profile | Generally recognized as safe | Excellent safety record |
| Regulatory Status | Generally recognized as safe (GRAS) | Well-established safety profile |
| Synergy Potential | Works well with omega-3s and cholinergics | Complements racetams, omega-3s, and PS itself |
Citicoline Sodium Powder COA
ProVita Biotech’s Citicoline Sodium powder demonstrates exceptional quality with an assay of 99% purity, exceeding the industry standard specification of ≥98.0%, as confirmed by HPLC analysis. Heavy metal testing verifies compliance with strict safety parameters, with levels well below the 10ppm maximum limit, including Lead (<0.5ppm), Arsenic (<1ppm), Cadmium (<0.5ppm), and Mercury (<0.1ppm). Residual solvent analysis confirms the absence of Class 1 solvents and acceptably low levels of Class 2 and 3 solvents, all within ICH Q3C(R6) guidelines. This premium-grade Citicoline Sodium meets or exceeds USP/EP pharmaceutical standards and has received third-party verification through rigorous laboratory testing by independent ISO-certified facilities. At ProVita Biotech, we prioritize product quality and safety through comprehensive testing and quality assurance protocols, providing supplement manufacturers and distributors with confidence in our ingredients for their cognitive health formulations.
Application
Mental Energy
Citicoline boosts brain energy metabolism by enhancing mitochondrial function and increasing ATP production. This nootropic compound supports cerebral glucose utilization, providing sustainable mental energy without the crash associated with stimulants. Studies show Citicoline increases frontal lobe bioenergetics by up to 13.6%, making it ideal for combating mental fatigue and brain fog, especially during demanding cognitive tasks.
Focus & Attention
Citicoline significantly enhances attention span and concentration by optimizing dopamine signaling in the brain. Clinical research demonstrates improved performance on attention tasks after Citicoline supplementation, with studies showing a 27% improvement in attention test scores. Its ability to increase acetylcholine levels further supports sustained focus, making it a powerful tool for productivity, academic performance, and ADHD management.
Memory Enhancement
Citicoline directly supports memory formation and recall by providing essential building blocks for brain cell membranes. By increasing phosphatidylcholine synthesis, it promotes neuroplasticity and enhances both short-term and long-term memory functions. Research shows Citicoline improves verbal memory by up to 16% and logical memory by 18%, making it valuable for students, aging adults, and anyone seeking cognitive protection and enhancement.
Citicoline Sodium Powder Manufacturing Process
• Raw Materials Preparation: Selection of pharmaceutical-grade cytidine 5′-monophosphate, methyl alcohol, and specialized catalyzers subjected to rigorous quality verification.
• Synthesis: Controlled chemical reaction between cytidine 5′-monophosphate and activated compounds using proprietary catalysts in specialized reaction vessels for maximum yield.
• Cooling: Precise temperature reduction under controlled conditions to prepare solution for subsequent purification steps.
• Filtration: Advanced filtration technology removes solid impurities while the mother liquor undergoes a specialized recovery process to maximize efficiency.
• pH Adjustment: Careful pH optimization to ensure chemical stability and prepare the solution for ion exchange purification.
• Ion Exchange: Advanced chromatographic separation using specialized resins to eliminate impurities and achieve pharmaceutical-grade purity.
• Concentration: Controlled evaporation process to achieve optimal solution concentration for crystallization.
• Crystallization: Addition of high-quality ethyl alcohol as an anti-solvent under precise conditions to form pure Citicoline Sodium crystals.
• Drying: State-of-the-art vacuum drying technology reduces moisture content to below 1% while preserving chemical integrity.
• Finished Product: Final 99% pure Citicoline Sodium powder undergoes comprehensive quality testing including HPLC assay, heavy metals analysis, microbial testing, and residual solvent screening to ensure compliance with international pharmacopeia standards.
Citicoline Benefits
Cognitive Enhancement
- Boosts mental energy and reduces brain fog
- Enhances focus and concentration for extended periods
- Improves memory formation and information recall
- Accelerates mental processing speed and clarity
- Supports executive function and decision-making abilities
Brain Health
- Increases phosphatidylcholine production for brain cell membrane integrity
- Elevates acetylcholine levels for improved neural communication
- Protects neurons from oxidative damage and toxicity
- Enhances cerebral blood flow for better nutrient delivery
- Supports mitochondrial function and brain energy metabolism
Recovery & Protection
- Aids recovery after traumatic brain injuries and concussions
- Reduces cognitive decline associated with aging
- Helps repair damaged neuron membranes
- Supports stroke recovery and rehabilitation
- Provides neuroprotection against environmental toxins
Additional Benefits
- Improves visual acuity and processing in certain conditions
- Enhances mood and motivation through dopamine modulation
- Reduces symptoms in attention deficit disorders
- Supports addictive behavior recovery by balancing neurotransmitters
- Works synergistically with other nootropics for enhanced effects
Physical Performance
- Improves reaction time and hand-eye coordination
- Enhances mind-muscle connection during physical training
- Supports mental endurance during prolonged physical activity
- Accelerates motor learning for new physical skills
- Reduces mental fatigue during intense exercise
Where to buy Citicoline bulk powder?
Looking for premium Citicoline Sodium bulk powder? ProVita Biotech stands as China’s leading manufacturer and supplier of pharmaceutical-grade Citicoline. Our state-of-the-art production facility delivers 99% pure Citicoline Sodium powder to nutraceutical companies, supplement manufacturers, and research institutions worldwide.
Why Choose ProVita Biotech?
- Certified 99% pure Citicoline Sodium (CAS: 33818-15-4)
- ISO-certified manufacturing processes
- Competitive wholesale pricing with volume discounts
- Comprehensive COA documentation with every order
- Fast global shipping with secure packaging
- Dedicated account representatives for seamless procurement
Our Citicoline Sodium powder undergoes rigorous quality control testing to ensure potency, purity, and stability. Whether you need kilograms or metric tons, ProVita Biotech delivers consistent quality for your cognitive enhancement formulations.
Contact our sales team today for current Citicoline Sodium bulk powder pricing and availability. Elevate your nootropic products with ProVita’s premium cognitive ingredients.
FAQs
Yes, CDP-choline and Citicoline are identical. These terms are used interchangeably in the industry, both referring to cytidine diphosphate-choline. At ProVita Biotech, we provide this compound in its most stable form, Citicoline Sodium (sodium CDP-choline).
Citicoline has dual status depending on the region. In the United States, it's regulated as a dietary supplement, while in Europe and Japan, it's approved as a prescription drug for certain neurological conditions. ProVita's Citicoline Sodium powder meets both pharmaceutical and supplement-grade requirements.
Citicoline works through multiple pathways: it increases acetylcholine synthesis, enhances dopamine release, supports phospholipid membrane formation, and improves cerebral blood flow. This multi-modal action makes it particularly effective for comprehensive cognitive formulations.
Unlike simple choline bitartrate, Citicoline delivers both choline and cytidine (which converts to uridine). This dual-nutrient approach provides superior bioavailability and crosses the blood-brain barrier more effectively, making it approximately 5x more potent for neurological applications.
Our customers frequently combine Citicoline with racetams (piracetam, oxiracetam), Bacopa monnieri, Lion's Mane mushroom, Phosphatidylserine, L-Theanine, and Rhodiola rosea. This creates comprehensive cognitive stacks targeting memory, focus, and mental clarity.
While both are premium choline sources, Citicoline provides additional neuroprotective benefits through its cytidine component. Alpha-GPC delivers more choline per gram (40% vs. 18%), but Citicoline offers broader cognitive benefits. Many manufacturers use both in different product lines or combine them in premium formulations.
Absolutely. This combination is highly synergistic—Citicoline provides the building blocks for neuronal membranes, while Phosphatidylserine enhances cell membrane fluidity and receptor function. Our technical team can provide ideal ratio recommendations for your specific applications.
Our Citicoline undergoes a proprietary synthesis process involving cytidine monophosphate and phosphorylcholine precursors, followed by multiple purification steps including recrystallization and spray drying. This ensures 99% purity with minimal residual solvents.
Our Citicoline Sodium is manufactured in ISO 9001, ISO 22000, and cGMP certified facilities. We provide full documentation including COA, heavy metal testing, microbial analysis, and stability studies with each bulk order.
Yes, we can provide custom micronization from 80-200 mesh based on your manufacturing requirements. Our technical team works closely with your formulation scientists to match specifications for optimal blending and encapsulation.
Yes, ProVita offers full turnkey OEM/ODM services for Citicoline-containing products, including capsules, tablets, powders, and functional beverages. Our R&D team can develop custom formulations based on your target market and specific cognitive enhancement goals.