Wholesale Creatine Ethyl Ester HCl Powder Supplier in China
China High-purity CEE HCl for Sports Nutrition, Energy, and Muscle Support, Available in Bulk at Competitive Factory Prices. Kosher, Halal, FDA-approved
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What is Creatine Ethyl Ester HCl?
Creatine Ethyl Ester HCl (CAS No. 15366 32 2), also known as Creatine Ethyl Ester Hydrochloride or CEE, is an advanced form of creatine monohydrate with an attached ester group, an organic compound formed by the reaction of carboxylic acid and alcohol. This modification improves its solubility, molecular stability, and bioavailability, allowing for better absorption than regular creatine monohydrate and reducing common side effects such as cramping and dehydration. CEE is a white crystalline powder with a purity of 99% HPLC, molecular formula C6H13ClN3O2, and molecular weight 195.64 g/mol. It is highly soluble in water and commonly used in sports nutrition for increasing energy, endurance, and muscle growth. Although creatine is not botanical, it naturally occurs in the body and is synthesized from amino acids found in meat and fish. ProVita Biotech is a leading bulk Creatine Ethyl Ester HCl powder supplier in China, providing high purity ingredients and OEM services for capsules, tablets, and private label formulations. The product is packed in 25kg fiber drums with inner PE liners to ensure stability and safety during storage and shipment.
Creatine Ethyl Ester VS Creatine Monohydrate
Creatine Monohydrate remains the most widely researched, stable, and cost-effective form of creatine, making it the industry standard for sports nutrition. It is ideal for brands prioritizing scientific validation and affordability.
Creatine Ethyl Ester (CEE), on the other hand, offers better solubility and absorption, with fewer side effects such as bloating or water retention. It is preferred for premium formulations or users seeking faster uptake and higher bioavailability.
Choose Creatine Monohydrate for proven performance and value and Choose Creatine Ethyl Ester HCl for enhanced absorption and premium supplement lines.
| Category | Creatine Ethyl Ester HCl (CEE) | Creatine Monohydrate |
|---|---|---|
| CAS Number | 15366 32 2 | 6020 87 7 |
| Other Names | Creatine Ethyl Ester Hydrochloride, CEE, Creatine Ester | Creatine Monohydrate, Creapure®, CM |
| Molecular Formula | C6H13ClN3O2 | C4H9N3O2·H2O |
| Molecular Weight | 195.64 g/mol | 149.15 g/mol |
| Appearance | White crystalline powder | White crystalline powder |
| Food Sources | Synthesized from amino acids in meat and fish | Synthesized from amino acids in meat and fish |
| Specifications | 99% HPLC | 99% HPLC |
| Purity | ≥99% | ≥99% |
| Solubility | Highly soluble in water and ethanol | Poorly soluble in water |
| Bioavailability | Very high due to esterification | Moderate, requires transport mechanism |
| Potency | High – effective at lower doses | Proven high efficacy at standard doses |
| Dosage (typical) | 1–3 g/day | 3–5 g/day |
| Half-life in body | Longer due to lipophilic nature | Shorter (rapid uptake) |
| Stability | Good stability in dry form, moderate in solution | Very stable in both solid and aqueous form |
| Popularity | Moderate (premium niche markets) | Extremely popular and widely used |
| Pricing (bulk) | Higher: $30–80/kg | Lower: $8–25/kg |
| Main Benefits | Better absorption, less bloating, higher muscle uptake | Proven performance, muscle strength, endurance, recovery |
| Side Effects | Rare (less water retention, less cramping) | Possible water retention and bloating |
| Applications | Premium pre-workout, capsules, tablets | Powders, drinks, capsules, mainstream creatine products |
| Taste | Slightly bitter | Neutral or mildly chalky |
| OEM Availability (ProVita Biotech) | Available for powder, capsule, and tablet | Available for powder, capsule, and tablet |
Creatine Ethyl Ester Certificate of Analysis(COA)
The Certificate of Analysis (COA) for ProVita Biotech’s Creatine Ethyl Ester HCl Powder confirms its exceptional purity and compliance with international quality standards. The product shows an assay (purity) of 99.83%, exceeding the minimum requirement of 98.0%, with chloride assay at 19.15% and loss on drying only 0.13%, ensuring superior stability. Heavy metals including lead (<3.0 ppm), arsenic (<0.1 ppm), cadmium (<0.1 ppm), and mercury (<0.1 ppm) all conform to safety limits. Residual solvents and microbial levels meet stringent specifications—Total Plate Count <1000 cfu/g, Yeast and Molds <10 cfu/g, and both E. coli and Salmonella negative. Testing is performed using validated in-house analytical methods following GMP procedures. The product is packaged in 25kg fiber drums with two-tier polyethylene inner bags to preserve freshness and prevent contamination. Every batch is tested against internal and third-party standards to ensure consistency, purity, and safety. ProVita Biotech guarantees that its Creatine Ethyl Ester HCl powder meets international quality and safety standards, demonstrating the company’s strong commitment to providing reliable, high-quality ingredients for supplement manufacturers and distributors worldwide.
Application
Sports Nutrition Supplements
Creatine Ethyl Ester HCl is widely used in sports nutrition formulas for its superior absorption and muscle uptake. It helps increase ATP production, enhancing strength, power, and endurance during high-intensity workouts. Compared to creatine monohydrate, CEE offers better bioavailability and reduces bloating, making it ideal for pre-workout and performance supplements.
Muscle Growth Products
In bodybuilding supplements, Creatine Ethyl Ester HCl supports lean muscle mass development by promoting faster energy recovery between training sessions. Its high solubility allows for lower dosages with effective results, making it a preferred ingredient in muscle gain powders, capsules, and tablets used by athletes and fitness enthusiasts.
Energy and Recovery Formulations
Creatine Ethyl Ester HCl is a key component in energy and recovery blends, helping restore cellular energy and reduce fatigue post-exercise. By improving creatine phosphate storage in muscles, it accelerates recovery and supports sustained performance. It’s often combined with amino acids, electrolytes, or carbohydrates in premium recovery supplements.
Creatine Ethyl Ester Manufacturing Process
ProVita Biotech produces high-purity Creatine Ethyl Ester HCl powder (99%) through a controlled chemical synthesis and purification process that ensures consistent quality, stability, and compliance with international safety standards.
Raw Material Selection
The process begins with pharmaceutical-grade creatine monohydrate and high-purity ethanol as key starting materials. All raw materials are carefully tested for identity, purity, and absence of contaminants before production begins.Esterification Reaction
Creatine monohydrate is reacted with ethanol under acidic catalytic conditions to form Creatine Ethyl Ester. This esterification process replaces the hydroxyl group with an ethyl ester group, improving solubility and absorption. The reaction parameters—temperature, pH, and reaction time—are tightly controlled to ensure high conversion efficiency and molecular stability.Neutralization and Crystallization
The reaction mixture is then neutralized with hydrochloric acid (HCl) to yield Creatine Ethyl Ester Hydrochloride. Controlled cooling allows pure CEE HCl crystals to form. These crystals are separated and washed to remove any unreacted residues or impurities.Filtration and Drying
The crystalline product is filtered, then gently dried under low temperature and vacuum conditions to preserve its white crystalline appearance and maintain moisture below 0.5%. This step ensures long-term stability and prevents degradation.Grinding and Sieving
The dried material is milled and sieved through a 40-mesh screen, producing a fine, uniform white powder suitable for blending into capsules, tablets, and functional powder formulations.Quality Control and Testing
Every batch undergoes rigorous HPLC testing, confirming ≥99% purity, and is analyzed for heavy metals (Pb, As, Cd, Hg), residual solvents, microbial limits, and moisture content. Testing is conducted in-house and verified by third-party laboratories to ensure compliance with international standards (GMP, ISO, and USP).Packaging and Storage
The finished Creatine Ethyl Ester HCl powder is packed in 25kg fiber drums with two-layer polyethylene bags inside to protect against moisture and oxidation. It is stored in a cool, dry, and well-ventilated area to preserve purity and potency during transport and shelf life.
Creatine Ethyl Ester Benefits
- Fast absorption – Creatine Ethyl Ester HCl supports quick uptake for rapid workout performance.
- High solubility – dissolves easily in water for smooth mixability in powders, capsules, and tablets.
- Supports strength and power – helps increase ATP availability for explosive training sessions.
- Enhances endurance – aids repeated high intensity efforts and short burst performance.
- Reduced bloating and water retention – a clean feel compared with some regular creatine products.
- Effective at lower servings – potent option for premium pre workout and muscle gain formulas.
- Stable and consistent – manufactured for 99 percent purity with tight moisture control.
- Stacks well – combines smoothly with amino acids, electrolytes, and carbohydrates.
- Formulation friendly – ideal for capsules, tablets, and flavored drink mixes.
- Quality assurance – in house and third party tested for purity, heavy metals, and microbes.
- Global supply – reliable bulk CEE powder for sports nutrition brands and distributors.
Where to buy bulk Creatine Ethyl Ester?
If you are looking for a trusted factory and supplier in China, ProVita Biotech Co., Ltd. is your best choice for high quality Creatine Ethyl Ester HCl powder in bulk. As a GMP-certified manufacturer, we specialize in producing Micronized Creatine, creatine derivatives, and Creatine Ethyl Ester tablets for global supplement brands and distributors.
Our bulk Creatine Ethyl Ester HCl powder is tested by third-party laboratories to ensure purity, safety, and consistency. We provide OEM and private label services for capsules, tablets, and powder formulations, offering flexible packaging and customized solutions to meet your market needs. All products come with Kosher, Halal, and ISO certificates, ensuring compliance with international standards.
ProVita Biotech offers competitive Creatine Ethyl Ester HCl price direct from our factory, fast delivery worldwide, and free samples for quality evaluation. Partner with China’s leading wholesale supplier to source reliable, high-purity ingredients for your sports nutrition and bodybuilding products.
FAQs
Creatine Ethyl Ester (CEE) is a highly bioavailable creatine derivative formed by esterifying creatine with ethanol. This process improves solubility and absorption compared to traditional creatine monohydrate. ProVita Biotech supplies 99% pure Creatine Ethyl Ester HCl powder manufactured under GMP standards in China.
CEE works by enhancing the body’s ATP regeneration, which supports muscle power, endurance, and recovery during high-intensity exercise. Its ethyl ester structure allows for faster absorption and better cellular uptake than regular creatine forms.
Athletes, bodybuilders, and fitness enthusiasts benefit most from CEE supplementation due to its superior absorption, reduced bloating, and improved muscle energy. It’s ideal for use in Creatine Ethyl Ester tablets, Micronized Creatine powders, and performance formulas.
Typical recommended usage is 1–3 grams per day, depending on the product formulation. Due to its higher potency, CEE requires a smaller serving size compared to creatine monohydrate.
CEE is generally well tolerated. Unlike creatine monohydrate, it causes less bloating and water retention. All ProVita Biotech batches undergo third-party testing to ensure purity and safety before shipment.
Both are effective, but Creatine Ethyl Ester HCl offers faster absorption and higher bioavailability, while creatine monohydrate is more widely studied and affordable. CEE is preferred for premium sports nutrition formulations where solubility and efficiency matter most.
Creatine Ethyl Ester HCl is an esterified form known for high absorption and reduced side effects, while Creatine HCL is a hydrochloride form with strong solubility and stability. Both are effective, but CEE may offer smoother muscle uptake with minimal gastrointestinal discomfort.
Our production follows GMP, ISO, and HACCP standards. We synthesize CEE from pharmaceutical-grade creatine through esterification, followed by crystallization, filtration, and drying. Each batch is analyzed by HPLC for purity and verified by third-party labs for heavy metals and microbes.
The standard MOQ for bulk Creatine Ethyl Ester HCl powder is 25kg (1 drum). Custom quantities are available for OEM and private label customers upon request.
We offer GMP, ISO9001, Kosher, Halal, and third-party test reports (COA, MSDS, HPLC) with every shipment, ensuring compliance with international regulations.
Yes. We provide OEM services for Creatine Ethyl Ester tablets, capsules, and powder blends, complete with label design, customized packaging, and export support.
We ship globally via air, sea, or courier (DHL, FedEx, UPS). ProVita Biotech ensures safe, compliant export from China with professional logistics and full documentation support.
We offer free samples (100–200g) of Creatine Ethyl Ester HCl powder for quality evaluation. Shipping costs may be covered by the buyer or deducted from your bulk order.
Pricing depends on order quantity, purity, and packaging. Contact ProVita Biotech directly for competitive factory pricing on bulk, OEM, or wholesale orders.