Bulk Cytisine Powder Supplier in China
Cytisine for Smoking Cessation: High Purity ≥99% HPLC, Wholesale Prices, OEM Capsules & Tablets Available
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What is Cytisine?
Cytisine is a natural alkaloid primarily extracted from Laburnum and Cytisus species, widely recognized for its role in smoking cessation supplements and pharmaceutical research. Also known as Baptitoxine or Sophorine, Cytisine has the CAS number 485-35-8, a molecular formula of C11H14N2O, and a molecular weight of 190.24 g/mol. In its purest form, our Cytisine Powder offers ≥99% HPLC specifications, appearing as a white to off-white crystalline powder with reliable bioavailability. ProVita Biotech is the leading Cytisine Extract Supplier in China, providing bulk Cytisine at wholesale prices in secure 25kg/drum packaging, with strict GMP and ISO-certified quality control. Beyond supplying wholesale Cytisine raw material, we also offer OEM services for Cytisine capsules, Cytisine tablets, and custom formulations, helping supplement brands, eCommerce stores, and contract manufacturers worldwide ensure consistent supply, superior purity, and global compliance.
Sources of Cytisine
Cytisine is a plant-derived alkaloid most commonly obtained from Horsebean (Laburnum anagyroides), Cytisus species, and other legumes in the Fabaceae family. These botanical sources remain the primary natural supply for bulk Cytisine raw material used in supplements and pharmaceutical research. In addition to extraction from plants, Cytisine can also be produced through synthetic chemical methods, which ensure stable purity and large-scale availability. While microbial fermentation methods are still under research, they are not yet widely used in commercial production. As a trusted Cytisine Extract Supplier in China, ProVita Biotech guarantees consistent sourcing, whether from natural plant extracts or high-quality synthetic processes, to meet the needs of supplement companies, contract manufacturers, and distributors worldwide.
Cytisine vs Varenicline
Varenicline (Rx API) generally shows higher receptor affinity, longer half-life, and simpler dosing, making it the clinical standard where approved; Cytisine offers a natural-origin alternative with strong evidence, shorter courses and far lower ingredient cost, making it attractive for brands sourcing Cytisine Powder / Bulk Cytisine from a Wholesale Cytisine Raw Material partner like a Cytisine Extract Supplier in China.
| Item | Cytisine | Varenicline |
|---|---|---|
| CAS Number | 485-35-8 | 249296-44-4 |
| Other Names | Baptitoxine; Sophorine; (−)-Cytisine | Varenicline tartrate (API); brand names vary by market |
| Molecular Formula | C11H14N2O | C13H13N3 (base); commonly supplied as tartrate salt |
| Molecular Weight | 190.24 g/mol | 211.26 g/mol (base); ~475.9 g/mol (tartrate) |
| Appearance | White to off-white crystalline powder | White to off-white crystalline powder |
| Natural / Food Sources | Alkaloid from Laburnum (horsebean tree) and Cytisus spp.; not a food | None (fully synthetic API) |
| Typical Specifications | Ingredient grade ≥98–99% HPLC for Cytisine Powder | API grade ≥99% (compendial, e.g., HPLC) |
| Purity (commercial) | ≥98–99% for bulk ingredient | ≥99% API |
| Bioavailability (oral) | Moderate (rapid absorption; shorter exposure window) | High (~90%) with minimal metabolism |
| Mechanism / Potency | Partial agonist at α4β2 nAChR; lower receptor affinity than varenicline | Partial agonist at α4β2 nAChR; higher affinity/potency |
| Typical Dosing Pattern* | Tapered 20–25-day courses are common in products using cytisine (e.g., multiple daily 1.5 mg doses, then taper) | Titration to 1 mg twice daily after a 1-week ramp; usual course 12 weeks |
| Half-life (t½) | ~4–6 hours | ~24 hours |
| Stability / Storage | Stable when sealed, cool, dry, protected from light | Stable API; store sealed, cool, dry, protected from light |
| Popularity / Use | Long history in Eastern Europe; growing global interest for supplements and research | Widely used Rx therapy in many markets; strong clinical adoption |
| Pricing (very broad, indicative) | Much lower cost per kg (often low-to-mid 4-figures USD/kg depending on purity/MOQ) | Significantly higher API cost (often high 5- to 6-figures USD/kg depending on grade/volume) |
| Main Benefits | Natural origin; shorter course; competitive cost; accessible supply for brands; fits capsules/tablets | Strong evidence base; once- or twice-daily dosing after titration; long half-life aids adherence |
| Common Use Cases | Bulk Cytisine for supplement brands, distributors, OEM capsules/tablets, research | Prescription smoking-cessation medicines (where approved) |
Cytisine vs Nicotine
Cytisine and Nicotine are both alkaloids that act on nicotinic acetylcholine receptors, but their uses differ. Nicotine is naturally found in tobacco and is the addictive compound in cigarettes, while Cytisine Powder is a plant-derived alternative with partial agonist activity, often used in smoking cessation supplements and research. Cytisine is considered less addictive, more cost-effective, and a safer raw material for supplement companies.
| Item | Cytisine | Nicotine |
|---|---|---|
| CAS Number | 485-35-8 | 54-11-5 |
| Other Names | Baptitoxine; Sophorine | (S)-Nicotine; 3-(1-Methyl-2-pyrrolidinyl)pyridine |
| Molecular Formula | C11H14N2O | C10H14N2 |
| Molecular Weight | 190.24 g/mol | 162.23 g/mol |
| Appearance | White to off-white crystalline powder | Colorless to pale yellow oily liquid |
| Natural Sources | Laburnum (Horsebean), Cytisus spp. | Tobacco leaves (Nicotiana tabacum) |
| Specifications | ≥98–99% HPLC for Cytisine Powder | Pharmaceutical/nicotine base ≥99% |
| Purity (commercial) | High purity ≥98–99% | ≥99% for pharma grade |
| Bioavailability (oral) | Moderate | Very high, rapid absorption |
| Potency / Mechanism | Partial agonist at α4β2 nAChR (less addictive) | Full agonist at α4β2 nAChR (highly addictive) |
| Typical Dosage Pattern* | Structured, short smoking-cessation courses (1.5 mg tablets, tapering) | Variable from smoking/vaping; 1–2 mg per cigarette equivalent |
| Half-life (t½) | ~4–6 hours | ~1–2 hours |
| Stability / Storage | Stable, crystalline solid, 25kg/drum | Stable as liquid but volatile, requires sealed storage |
| Popularity / Use | Used in Eastern Europe, gaining attention worldwide in supplements | Widespread as addictive agent in tobacco and nicotine products |
| Pricing (indicative) | Much lower, affordable bulk powder for supplements (low-to-mid 4-figures USD/kg) | Higher cost depending on purity and form (pharma grade, nicotine base, nicotine salts) |
| Main Benefits | Natural, less addictive, effective for smoking cessation, cost-efficient | Strong stimulant, rapid effect, but addictive and harmful with chronic use |
Cytisine Powder Specifications
Our Cytisine Powder is tested by HPLC with an assay purity of 100.8% (NLT 97.0% and NMT 103.0%), ensuring high consistency and potency. Residual solvents fully comply with ICH Q3C international regulations, with no detectable harmful solvents such as methanol, acetone, or chloroform. Microbiological safety meets strict limits, with aerobic bacteria, yeast, mold, E. coli, Salmonella, and other pathogens all within compliance. Supplied in secure 25kg/drum packaging under quality standard YL-Q/Alk-016-2023, our bulk Cytisine raw material guarantees stability, safety, and reliable performance. ProVita Biotech ensures every batch meets international quality standards and independent third-party testing, demonstrating our commitment to product safety and excellence for global supplement manufacturers and distributors.
Application
Smoking Cessation Supplements
Cytisine Powder is widely recognized as a natural alternative to nicotine replacement therapy. By acting as a partial agonist of nicotinic receptors, it helps reduce withdrawal symptoms and cravings, making it a key ingredient in smoking cessation supplements.
Pharmaceutical Research
With its well-studied interaction with nicotinic acetylcholine receptors, bulk Cytisine raw material is frequently used in pharmaceutical research focused on addiction, neuroprotection, and central nervous system health.
OEM Capsules and Tablets
As a cost-effective and stable alkaloid, Cytisine is increasingly used in OEM formulations, including Cytisine capsules and Cytisine tablets. Supplement brands and distributors rely on trusted Cytisine Extract Suppliers in China like ProVita Biotech for consistent quality and supply.
Cytisine Manufacturing Process
The process begins with carefully selected Horsebean (Laburnum anagyroides) seeds and grass, followed by state-of-the-art extraction and purification technologies. Multiple quality control steps, including HPLC testing, guarantee purity and identity. The final product undergoes third-party analysis to ensure it meets global supplement and pharmaceutical requirements.
Key Steps:
- Raw Material Selection – Harvesting high-quality Horsebean seeds & grass.
- Drying & Grinding – Preparing plant material for extraction.
- Solvent Extraction – Using safe solvents to extract alkaloids.
- Concentration & Filtration – Removing impurities and concentrating active compounds.
- Purification – Advanced chromatographic purification to achieve ≥99% HPLC purity.
- Crystallization & Drying – Producing stable, white crystalline Cytisine powder.
- Quality Control Testing – HPLC, IR, COA, MSDS, microbial, and solvent residue checks.
- Final Packaging – Secure 25kg/drum packaging with labeling and traceability.
- Third-Party Verification – Independent labs confirm purity and compliance.
Cytisine Benefits
- Smoking cessation efficacy: Cytisine helps reduce cravings and withdrawal by acting as a partial α4β2 nicotinic receptor agonist. It is a cost-effective alternative to nicotine replacement therapy (NRT).
- Cytisine and NRT: Often used instead of NRT. Any combined or step-down use should be guided by healthcare professionals and local regulations.
- Cytisine nootropic: Early research suggests possible cognitive support through cholinergic modulation, which may enhance focus and working memory.
- Cytisine weight loss: Preliminary findings show potential in appetite control and energy balance, but it is not approved for weight-loss use.
- Cytisine antidepressant: Some studies indicate mood-modulating activity via nicotinic and dopaminergic pathways, but Cytisine is not an approved antidepressant.
- OEM formulations: Cytisine Powder (≥99% HPLC) is stable and easy to manufacture into capsules or tablets for OEM and private label brands.
- Natural origin: Derived from Horsebean and Cytisus species, available as Bulk Cytisine from a reliable Wholesale Cytisine Raw Material partner.
- Favorable cost profile: More affordable compared to many prescription alternatives, offering value for supplement companies and distributors.
- Is cytisine safe?: Generally safe when used within recommended dosages. Mild side effects may include gastrointestinal discomfort or sleep changes. Not recommended during pregnancy or breastfeeding.
- Quality and compliance: Manufactured under strict GMP and ISO standards with third-party testing, ensuring safety and reliability from a leading Cytisine Extract Supplier in China.
For ingredient marketing and formulation reference only. Not intended as medical advice.
Where to buy bulk Cytisine Powder?
If you are searching for where to buy Cytisine for smoking cessation, Cytisine supplements, or Cytisine 1.5 mg tablets, ProVita Biotech Co., Ltd. is your trusted choice. As the leading Cytisine manufacturer in China, we provide bulk Cytisine powder, Cytisine extract, and Cytisine tablets with factory-direct wholesale prices. Our China Cytisine factory is GMP-certified and compliant with international standards, offering full documentation including COA, HNMR, HPLC, LC-MS reports, as well as Kosher and Halal certificates. Every batch undergoes strict quality control and third-party testing to guarantee purity and safety.
We supply Cytisine for sale worldwide, exporting to the United States, Canada, UK, Europe, and Asia. Whether you need Cytisine pills, Cytisine extract liquid, or private label Cytisine supplement OEM solutions, our production capacity and global export experience make us one of the most reliable Cytisine suppliers.
Buying Information:
- MOQ: Flexible starting from 1kg for testing
- Bulk Pricing: Competitive factory-direct Cytisine cost at wholesale levels
- Lead Time: 3–7 working days for most orders
- Payment Terms: T/T, L/C, PayPal for samples
- Shipping Options: Air freight, sea freight, door-to-door delivery
With a strong reputation among Cytisine manufacturers, ProVita Biotech guarantees high-quality raw material, OEM tablets, and private labeling solutions for supplement brands, distributors, and contract manufacturers. Contact us today for a free sample and secure a stable supply of bulk Cytisine powder at the most competitive price.
FAQs
Cytisine and Varenicline act on the same nicotinic receptors, but Varenicline (marketed as Champix/Chantix) is a synthetic pharmaceutical drug, while Cytisine is a natural plant-derived alkaloid. Cytisine is more cost-effective and widely used in supplements and nutraceuticals, while Varenicline is only available as a prescription medication.
Zyban works as an antidepressant with secondary benefits for smoking cessation, while Cytisine directly targets nicotine receptors. Cytisine is often preferred in supplements and wellness products because of its natural origin and affordability.
Nicotine is a full agonist at nicotinic receptors and highly addictive. Cytisine is a partial agonist, meaning it reduces cravings without the same addiction potential. Many supplement brands use Cytisine powder as a safer alternative in smoking cessation formulations compared to nicotine patches or gum.
Our Cytisine Extract consistently meets ≥99% HPLC purity with full analytical documentation, including COA, HNMR, HPLC, and LC-MS reports.
We use advanced solvent extraction and multi-step purification from Horsebean (Laburnum anagyroides) seeds and grass, followed by crystallization and drying. Each batch undergoes strict GMP and ISO-certified quality control, plus third-party testing for safety and compliance.
Our MOQ starts at 1kg for testing, making it easy for supplement companies and contract manufacturers to trial. Bulk pricing is competitive and factory-direct, helping clients optimize their Cytisine cost for large-scale production.
Yes. We supply OEM Cytisine tablets, Cytisine 1.5 mg capsules, and private labeling services, tailored to the needs of supplement brands, eCommerce stores, and distributors.
Absolutely. ProVita Biotech has global export experience to the United States, Canada, UK, Europe, and Asia, with reliable shipping options including air freight, sea freight, and door-to-door delivery.
Most bulk orders ship within 3–7 working days, depending on order size and destination.
We offer GMP, ISO, Kosher, and Halal certificates, along with COA, HNMR, HPLC, and LC-MS analysis for every batch to ensure compliance and traceability.
Yes. We partner with independent third-party laboratories to validate purity, safety, and compliance, providing additional assurance to our B2B customers.
Cytisine 1.5 mg tablets remain the most popular format for smoking cessation, but demand for Cytisine capsules is growing among supplement companies targeting nootropic and wellness markets.