Bulk D-Mannose Powder 99% Supplier in China
High-purity, plant-derived D-Mannose Powder for urinary health, women’s health, functional nutrition, capsules, tablets, and powder formulations. Provita Biotech supplies white crystalline D-mannose with ≥99% purity, excellent water solubility, controlled manufacturing, and complete batch quality testing for global nutraceutical brands and manufacturers.
- White crystalline D-mannose powder with 99.69% assay
- Freely Water Soluble - Suitable for capsules, tablets, sachets, drink powders
- Annual Manufacturing Capability of 1000 tons
- Factory direct wholesale pricing with COA, free samples
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Bulk D-Mannose Powder 99%
| Product Name | D-Mannose Powder |
| Other Names | D-Mannose, D-(+)-Mannose |
| Main Specifications | ≥99% D-Mannose |
| CAS No. | 3458-28-4 |
| Molecular Formula | C₆H₁₂O₆ |
| Molecular Weight | 180.16 g/mol |
| Appearance/Color | White crystalline powder or granule |
| Solubility | Freely soluble in water |
| Source | Plant-derived, from birch source through glucose isomerization |
| Package | 25 kg/drum, lined with double-layer PE bags |
| Annual Capability | 1000 tons |
What is D-Mannose?
D-Mannose Powder is a naturally occurring monosaccharide, hexose, and simple carbohydrate that is structurally related to glucose and is often described as a glucose epimer. It occurs naturally in plant-derived polysaccharides, including birch hemicellulose, and in small amounts in foods and fruits such as cranberries, pineapples, apples, oranges, and peaches. Commercial D-mannose is purified to provide a much more concentrated ingredient than the small amounts naturally present in foods, making it suitable for dietary supplements, urinary health products, women’s health formulas, and functional nutrition products. D-mannose is also known as D-(+)-Mannose and mannopyranose, with CAS No. 3458-28-4, molecular formula C₆H₁₂O₆, and molecular weight 180.16 g/mol. Provita Biotech supplies 99% D-Mannose Powder, specified by HPLC, as a white crystalline powder that is freely soluble in water. The latest Provita COA shows an assay result of 99.69%, 99.2% transmittance, and a clean white crystalline appearance.
Because D-mannose is a highly water-soluble simple sugar, it is well suited to oral supplement formats such as powders, sachets, capsules, tablets, and other water-dispersible formulations. The supplied product information notes that only a small amount is metabolized and that much of the ingested D-mannose is excreted unchanged, which is relevant to its widespread use in urinary tract health formulations. Provita Biotech is a leading bulk D-Mannose Powder supplier in China, providing 25 kg/drum bulk packaging with double-layer PE bag liners, along with OEM and private-label services for D-mannose capsules, tablets, powder formulas, and other finished dietary supplements.
D-Mannose Specifications
Provita Biotech supplies high-purity D-Mannose Powder under a controlled in-house quality standard for dietary supplement manufacturers, contract manufacturers, and ingredient distributors. The current production batch, YWD20260508-1, tested at 99.69% D-mannose assay, with a specification range of 98.0-102.0%. The material is a white crystalline powder, with 99.2% transmittance, specific rotation of +13.84°, melting point of 127.8-131.6°C, loss on drying of only 0.09%, and residue on ignition of 0.01%.
Heavy-metal control is an important part of Provita Biotech’s D-mannose quality program. The current batch meets limits of Pb ≤1.0 mg/kg, Hg ≤0.1 mg/kg, Cd ≤0.5 mg/kg, As ≤1.0 mg/kg, and total heavy metals ≤10 mg/kg. Actual results were Pb <1.0 mg/kg, Hg <0.1 mg/kg, Cd <0.5 mg/kg, As <0.5 mg/kg, and total heavy metals <10 mg/kg. Microbiological specifications include Total Plate Count ≤500 CFU/g, Mold & Yeast ≤100 CFU/g, with E. coli, Salmonella, and Staphylococcus aureus absent. Bulk density was 0.43 g/mL and compacted density 0.65 g/mL, supporting consistent handling in bulk ingredient and supplement manufacturing.
Provita’s D-mannose is packed 25 kg net per drum with double-layer PE inner bags. The referenced batch was manufactured on May 8, 2026, with an expiry date of May 7, 2029, providing a three-year stated shelf-life period for that batch. The specification also controls particle size, including ≥99% through 30 mesh and a defined 60-mesh distribution, helping maintain consistent powder or granular characteristics for capsules, tablets, sachets, drink powders, and other supplement formulations.
The current COA is issued against Provita Biotech’s in-house standard. For customers requiring additional international compliance documentation, residual-solvent testing can be performed separately using an appropriate validated chromatographic method, such as GC testing aligned with ICH Q3C or USP <467>, when applicable to the customer’s market or finished-product requirements. Provita Biotech places strong emphasis on D-mannose purity, heavy-metal control, microbiological safety, batch consistency, traceability, and packaging integrity, helping supplement manufacturers and distributors source reliable bulk D-Mannose Powder. Independent third-party verification can also be requested when required by customer quality programs.
| Test Item | Specification | COA Result |
|---|---|---|
| Description | White crystalline powder or granule | White crystalline powder |
| Clarity | Clear and colorless | Complies |
| Transmittance | ≥95% | 99.2% |
| Assay / Purity | 98.0-102.0% | 99.69% |
| Specific Rotation [α]D | +13.3° to +14.3° | +13.84° |
| Melting Point | 126.0-134.0°C | 127.8-131.6°C |
| Loss on Drying | ≤0.5% | 0.09% |
| Residue on Ignition | ≤0.1% | 0.01% |
| Lead (Pb) | ≤1.0 mg/kg | <1.0 mg/kg |
| Mercury (Hg) | ≤0.1 mg/kg | <0.1 mg/kg |
| Cadmium (Cd) | ≤0.5 mg/kg | <0.5 mg/kg |
| Arsenic (As) | ≤1.0 mg/kg | <0.5 mg/kg |
| Total Heavy Metals | ≤10 mg/kg | <10 mg/kg |
| Bulk Density | 0.30-0.50 g/mL | 0.43 g/mL |
| Compacted Density | 0.45-0.75 g/mL | 0.65 g/mL |
| Total Plate Count | ≤500 CFU/g | Complies |
| Mold & Yeast | ≤100 CFU/g | Complies |
| E. coli | Absent | Absent / Complies |
| Salmonella | Absent in 25 g | Absent / Complies |
| Staphylococcus aureus | Absent | Absent / Complies |
| Residual Solvents | Not specified on current COA | Separate testing available if required |
| Packaging | 25 kg/drum | Double-layer PE bags inside drum |
| Inspection Standard | Provita In-House Standard | Passed |
Application
D-Mannose Powder is widely used as a functional ingredient in urinary tract health supplements, bladder health formulas, women’s health supplements, functional nutrition products, capsules, tablets, gummies, sachets, stick packs, drink powders, effervescent products, and other water-soluble nutritional formulations. Because D-mannose is a naturally occurring monosaccharide with good water solubility, it can be used as a single active ingredient or combined with complementary ingredients such as cranberry extract, probiotics, vitamins, and botanical extracts. Provita Biotech’s product information specifically identifies urinary health supplements, women’s health products, functional nutrition products, capsules, tablets, and powder formulations as key applications.
Urinary Tract & Bladder Health Supplements
The primary application of bulk D-Mannose Powder is in urinary tract and bladder health supplements. D-mannose is commonly incorporated into dietary supplements designed to support normal urinary tract function and urinary wellness. Its excellent water solubility makes it especially suitable for capsules, powder sachets, stick packs, and drink-mix formulations. Provita’s product information notes that D-mannose is widely used in urinary health supplements because of its interaction with bacterial adhesion mechanisms, particularly those involving E. coli.
Women’s Health Formulations
D-Mannose Powder is also widely used in women’s health supplements, particularly products positioned for daily urinary and bladder wellness. Supplement manufacturers can formulate D-mannose alone or combine it with ingredients such as cranberry extract, probiotics, vitamin C, and selected botanical extracts to develop differentiated women’s health products. Common finished-product formats include D-mannose capsules, tablets, gummies, sachets, and powdered drink formulas, allowing brands to target different consumer preferences and dosage requirements.
Functional Nutrition & Powder Formulations
With its white crystalline appearance and high water solubility, D-mannose is well suited to functional nutrition products and water-dispersible formulations. It can be incorporated into instant drink powders, stick packs, sachets, effervescent products, capsules, and tablets, either as a standalone ingredient or as part of multi-ingredient formulas. This formulation flexibility makes bulk D-mannose attractive to supplement manufacturers developing convenient daily-use nutritional products for urinary and women’s health markets.
D-Mannose Manufacturing Process
Provita Biotech manufactures D-Mannose Powder 99% through a controlled conversion, purification, separation, crystallization, and finishing process designed to achieve high purity and consistent batch quality. According to Provita’s production flow chart, purified glucose and purified water are first prepared as a soluble sugar solution, followed by isomerization, decolorization and filtration, desalination, chromatographic separation, concentration, secondary decolorization and filtration, crystallization, centrifugal separation, drying, sieving, metal detection, and final metered packaging.
Glucose + Purified Water → Soluble Sugar → Isomerization → Decolorization & Filtration → Desalination → Chromatographic Separation → Concentration → Decolorization & Filtration → Crystallization → Centrifugal Separation → Drying → Sieving → Metal Detection → Packaging
1. Glucose Solution Preparation and Isomerization
Purified glucose is dissolved in purified water to prepare a controlled soluble sugar solution. The solution then undergoes isomerization, converting part of the glucose into D-mannose and creating the starting material for subsequent purification.
2. Decolorization, Filtration and Desalination
The converted sugar solution passes through decolorization and filtration to remove color-forming substances and suspended impurities. A desalination step further reduces ionic impurities, helping improve the purity and clarity of the D-mannose solution.
3. Chromatographic Separation and Concentration
Chromatographic separation is used to separate D-mannose from glucose and other sugar components. The D-mannose-rich fraction is then concentrated, followed by another decolorization and filtration step to further refine the solution before crystallization.
4. Crystallization and Centrifugal Separation
The purified D-mannose solution undergoes concentrated crystallization, allowing high-purity D-mannose crystals to form. Centrifugal separation is then used to separate the crystalline product from the remaining liquid phase.
5. Drying, Sieving and Metal Detection
The separated D-mannose crystals are carefully dried to control moisture, then passed through sieving as OPRP1 to achieve consistent powder or granular characteristics. Before packaging, the product passes through metal detection/removal as CCP1, an important food-safety control point in the manufacturing process.
6. Quality Testing and Bulk Packaging
After processing, the finished D-Mannose Powder is tested for identity, assay, physical properties, heavy metals, and microbiological quality before batch release. Provita’s referenced production batch achieved 99.69% assay, compared with a specification range of 98.0-102.0%, together with 99.2% transmittance, 0.09% loss on drying, 0.01% residue on ignition, and compliant microbiological results. Heavy-metal controls include Pb ≤1.0 mg/kg, Hg ≤0.1 mg/kg, Cd ≤0.5 mg/kg, As ≤1.0 mg/kg, and total heavy metals ≤10 mg/kg.
Finished D-mannose is packed in 25 kg drums lined with double-layer PE bags for bulk shipment to dietary supplement manufacturers and ingredient distributors. Provita Biotech applies controlled manufacturing, batch testing, traceability, and safety checks throughout production to support customers serving international supplement markets. Third-party laboratory testing can also be provided when required for customer qualification or market-specific quality programs.
The result is a high-purity, white crystalline D-Mannose Powder 99% suitable for capsules, tablets, sachets, drink powders, and other nutraceutical formulations, with consistent quality from raw-material conversion through final packaging.
D-Mannose Benefits
- Supports Urinary Tract Health – D-mannose is widely used in supplements formulated to support normal urinary tract function and everyday urinary wellness.
- Supports Bladder Health – Commonly included in bladder health supplements and urinary care formulations.
- Helps Reduce Bacterial Adhesion – D-mannose may help reduce the adhesion of certain bacteria, particularly E. coli, to urinary tract epithelial cells.
- Popular for Women’s Health Formulas – Frequently used in women’s urinary health supplements, either alone or combined with cranberry extract, probiotics, and other functional ingredients.
- Potential Prebiotic Support – D-mannose may interact with the gut microbiota and has potential applications in intestinal health formulations.
- Plant-Derived Clean-Label Ingredient – A naturally occurring monosaccharide suitable for clean-label dietary supplements and functional nutrition products.
- Highly Water Soluble – Freely soluble in water, making D-mannose powder suitable for capsules, tablets, sachets, stick packs, and drink powder formulations.
Where to Buy Bulk D-Mannose Powder
Looking for a reliable bulk D-Mannose Powder supplier in China? ProVita Biotech Co., Ltd. supplies high-quality D-Mannose Powder 99% for dietary supplement manufacturers, nutraceutical brands, distributors, and contract manufacturers worldwide. As an experienced D-Mannose manufacturer and wholesale supplier, ProVita provides competitive D-Mannose price per kg, consistent batch quality, 25 kg/drum bulk packaging, COA and specification documents, free samples, and optional third-party quality testing.
In addition to bulk D-Mannose raw material, ProVita Biotech provides OEM and private-label D-Mannose supplements, including D-Mannose capsules, D-Mannose tablets, D-Mannose gummies, sachets, stick packs, and powder formulas. Custom formulas combining D-Mannose with cranberry extract, probiotics, vitamins, and other functional ingredients are also available. Customers can request relevant GMP, Kosher, Halal, quality and regulatory documentation where applicable to the product or OEM project.
- D-Mannose Powder 99% direct from China supplier
- Competitive bulk and wholesale D-Mannose price
- 25 kg/drum standard bulk packaging
- Free D-Mannose sample available
- COA, specifications and technical documents
- Third-party testing available on request
- OEM D-Mannose capsules, tablets and gummies
- Private-label and custom formulation services
- Global shipping for supplement manufacturers and distributors
Contact ProVita Biotech for the latest bulk D-Mannose Powder price, free sample, COA, OEM quotation, and wholesale supply information.
FAQs
ProVita Biotech supplies high-purity D-Mannose Powder 99% for dietary supplement and functional nutrition applications. The specification range is 98.0% to 102.0% assay, while the referenced production batch achieved an actual assay of 99.69%.
Yes. D-Mannose is freely soluble in water, making it suitable for capsules, tablets, sachets, stick packs, drink powders, and other water-dispersible supplement formulations.
The manufacturing process starts with glucose and purified water, followed by soluble sugar preparation, isomerization, decolorization and filtration, desalination, chromatographic separation, concentration, secondary filtration, crystallization, centrifugal separation, drying, sieving, metal detection, and final packaging.
Chromatographic separation helps separate the D-mannose-rich fraction from glucose and other sugar components before further concentration and crystallization. This purification stage is important for producing high-purity D-Mannose Powder 99% with consistent commercial quality.
D-mannose exists as alpha and beta anomers. Classic sensory research found α-D-mannose to taste sweet and β-D-mannose to taste bitter, while an equilibrium mixture can produce a more complex taste profile. Therefore, D-mannose may taste mildly sweet with a slight bitter aftertaste depending on its anomeric composition and finished formulation.
D-mannose is not generally considered a diuretic, so it should not be described as an ingredient that directly increases urine production. D-mannose is absorbed and handled differently from ordinary dietary glucose, and research has examined its appearance and activity in the urinary tract. In finished supplements, users are also often instructed to consume D-mannose with water, and greater fluid intake itself can increase urination.
For dietary supplement products, we recommend using compliant structure/function positioning such as "supports urinary tract health," "supports bladder health," or "supports urinary wellness" rather than claiming that D-mannose treats, cures, or prevents urinary tract infections.
This distinction is especially important because a large 2024 randomized clinical trial found that daily D-mannose did not significantly reduce recurrent clinically suspected UTIs in women receiving primary care. Supplement brands should review claims according to the regulations of their target market.
Bulk D-Mannose Powder is mainly used in urinary tract health supplements, bladder health products, women's health formulas, functional nutrition products, capsules, tablets, gummies, sachets, stick packs, and powdered drink formulations.
Yes. D-mannose and cranberry extract are commonly considered complementary ingredients for urinary and women's health formulations. Manufacturers may also develop combination products containing D-mannose, cranberry extract, probiotics, vitamins, and selected botanical ingredients.
Yes. In addition to bulk D-Mannose Powder, ProVita Biotech can support OEM D-Mannose gummies, subject to formula evaluation, dosage requirements, destination-market regulations, packaging, and production MOQ.
ProVita Biotech provides OEM and private-label support for formats such as:
- D-Mannose capsules
- D-Mannose tablets
- D-Mannose gummies
- D-Mannose sachets
- D-Mannose stick packs
- D-Mannose powder blends
- D-Mannose + cranberry formulations
- Multi-ingredient women's health formulas
Custom formulas, dosage, packaging, labeling, and finished-product specifications can be discussed according to the customer's project.
The standard bulk package is 25 kg/drum, with the D-mannose packed inside double-layer PE bags for additional protection during storage and transportation.
Yes. D-Mannose Powder samples can be provided to qualified supplement manufacturers, distributors, formulators, and purchasing companies for evaluation. Contact ProVita Biotech with your company information, intended application, and estimated annual demand.
D-Mannose Powder wholesale price depends on purchase quantity, purity specification, packaging, order frequency, destination, freight cost, and OEM requirements. Contact ProVita Biotech for the latest D-Mannose Powder 99% factory price, price per kg, and bulk quotation.
Yes. Commercial D-Mannose batches can be supplied with a Certificate of Analysis (COA) showing relevant quality parameters. The referenced COA includes assay, transmittance, specific rotation, melting point, loss on drying, residue on ignition, heavy metals, bulk density, compacted density, and microbiological testing.
The current specification controls:
- Lead (Pb): ≤1.0 mg/kg
- Mercury (Hg): ≤0.1 mg/kg
- Cadmium (Cd): ≤0.5 mg/kg
- Arsenic (As): ≤1.0 mg/kg
- Total Heavy Metals: ≤10 mg/kg
The referenced batch recorded Pb <1.0 mg/kg, Hg <0.1 mg/kg, Cd <0.5 mg/kg, As <0.5 mg/kg, and total heavy metals <10 mg/kg.
Yes. Third-party laboratory testing can be arranged when required by supplement manufacturers, distributors, importers, or customer quality-control programs. Testing requirements should be confirmed before ordering because the required parameters can differ by market and application.
Depending on the product, destination market, and order requirements, ProVita Biotech can provide or discuss relevant documentation such as COA, product specification, SDS/MSDS, manufacturing flow chart, allergen information, GMO statements, and quality documents. Requirements for GMP, Halal, Kosher, or other certificates should be confirmed with our sales team for the specific D-mannose product or OEM project rather than assumed to apply automatically.
The supplied granular D-mannose specification includes ≥99% through 30 mesh, with a defined 60-mesh particle-size distribution. Buyers requiring a particular powder or granular specification should confirm particle-size requirements before production.