Fermentation-Derived Trans-Resveratrol 99% Powder Supplier in China
Provita Biotech manufactures and supplies high-purity Fermentation-Derived Trans-Resveratrol 99% Powder for dietary supplements, functional nutrition, healthy-aging formulas and cosmetic applications. Produced through controlled fermentation rather than Japanese knotweed extraction, it offers consistent trans-resveratrol content, controlled impurities and customizable particle-size options.
- ≥99.0% trans-resveratrol by HPLC
- Fermentation-derived, non-knotweed source
- kosher, halal, HACCP, FSMA Certified
- 500 tons Resveratrol ingredients exported annually
- Bulk supply with COA, samples and OEM formulation support
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Fermentation-Derived Resveratrol Powder
| Product Name | Fermentation-Derived Resveratrol 99% |
| Other names | Bio-fermented Trans-Resveratrol, Fermented Resveratrol, Biosynthetic Trans-Resveratrol, Yeast-Derived Trans-Resveratrol, Synthetic Trans-Resveratrol 99%, Microbial Trans-Resveratrol, Trans-Resveratrol 99% Fermentation Powder, Micronized Trans-Resveratrol 99% Powder |
| CAS Number | 501-36-0 |
| Molecular formula | C14H12O3 |
| Molecular Weight | 228.24 g/mol |
| Appearance | Off-white fine powder |
| specifications | Trans-Resveratrol 99% by HPLC, Custom mesh size, micronized available |
| Packaging | 25 kg/drum, double PE liners |
| OEM Services | Custom formulation, Private label capsules, Private label tablets, Private label gummies, powder, contract manufacturing, custom private label & logo service available |
What Is Fermentation-Derived Trans-Resveratrol?
Fermentation-Derived Trans-Resveratrol is a high-purity polyphenol ingredient produced through controlled microbial fermentation, followed by filtration, separation, purification, crystallization and drying. Unlike conventional resveratrol extract, it is not extracted from Japanese knotweed, grape skins or other botanical raw materials. Resveratrol naturally occurs in red grapes, grape skins, berries, peanuts and Polygonum cuspidatum, but the fermentation-derived form provides more consistent purity and batch-to-batch quality.
Also known as fermented trans-resveratrol, biosynthetic trans-resveratrol, micronized resveratrol and trans-3,5,4′-trihydroxystilbene, this ingredient has CAS No. 501-36-0, the molecular formula C₁₄H₁₂O₃ and a molecular weight of 228.24 g/mol. Provita supplies Trans-Resveratrol 99% HPLC as a white to off-white crystalline powder. It is poorly soluble in water and has limited oral bioavailability because it is rapidly metabolized after absorption.
Standard packaging is 25 kg per drum with double PE liners. Provita Biotech also offers micronized trans-resveratrol powder with customized mesh sizes to improve powder dispersion and formulation flexibility, as well as liposomal resveratrol for advanced delivery systems.
Provita Biotech is a leading bulk Fermentation-Derived Trans-Resveratrol powder supplier in China, with an annual export capacity of up to 500 tons. In addition to bulk Resveratrol 99% Powder, we provide liposomal resveratrol, resveratrol capsules, tablets, gummies, OEM manufacturing, private-label services and customized supplement formulations for global dietary supplement brands and contract manufacturers.
Fermented Resveratrol vs Japanese Knotweed Extract
Most plant-derived resveratrol is extracted from Japanese knotweed, also known as Polygonum cuspidatum. Because botanical raw materials are affected by growing location, soil, harvesting and storage, their trans-resveratrol content and impurity profile may vary between batches. Buyers must also carefully control pesticides, heavy metals, residual solvents, polycyclic aromatic hydrocarbons, or PAHs, and naturally occurring compounds such as emodin.
Provita Fermentation-Derived Trans-Resveratrol 99% Powder is produced through controlled yeast fermentation, followed by filtration, extraction, purification, crystallization, decolorization and drying. This production method does not depend on Japanese knotweed or other agricultural raw materials, helping deliver more consistent purity, color and batch-to-batch quality.
A representative Provita batch achieved 99.90% HPLC purity, 99.60% assay and less than 0.01% total impurities. It also met specified limits for residual ethanol, heavy metals and microbiological contaminants. Batch-specific testing can also be arranged for PAHs, emodin, pesticide residues and other market-specific contaminants.
For supplement brands concerned about botanical sourcing and complex contaminant testing, fermented trans-resveratrol provides a clean, traceable and highly standardized alternative to Japanese knotweed extract. Provita supports third-party testing, batch-specific COAs and quality documentation for bulk Resveratrol 99% Powder supplied to global manufacturers and private-label brands.
Trans-Resveratrol 99% Powder Certificate of Analysis(COA)
ProVita Biotech controls every batch of Fermentation-Derived Trans-Resveratrol 99% Powder through identity, potency, impurity, density, residual solvent, heavy metal and microbiological testing. The COA for batch 111D2607131 reports 99.90% HPLC purity and 99.60% HPLC assay, confirming compliance with the minimum specification of 99.0%. The product was manufactured on July 13, 2026, packed in 25 kg drums, and assigned an expiration date of July 12, 2028.
Assay vs Purity
Assay and purity measure different aspects of ingredient quality. HPLC purity describes the proportion of the target trans-resveratrol peak compared with other detected chromatographic components. Assay measures the actual amount of trans-resveratrol present in the powder according to the analytical method and calculation basis. Therefore, a batch can show 99.90% purity and 99.60% assay without any inconsistency.
The high assay confirms the active ingredient concentration, while the purity result demonstrates a very clean chromatographic profile. Both values are important for supplement manufacturers that require accurate label claims, consistent formulation input and reliable finished-product potency.
Single and Total Impurities
The maximum single impurity specification is ≤0.10%, while the tested result was <0.01%. Total impurities are controlled to ≤0.50%, with the batch also testing at <0.01% by HPLC.
Potential impurities may include fermentation-related byproducts, residual starting materials, cis-resveratrol, oxidation or degradation products, process intermediates and unidentified trace chromatographic peaks. The very low single and total impurity results indicate effective purification, crystallization and process control.
Bulk Density and Tapped Density
Bulk density measures the weight of loose powder within a defined volume before mechanical compaction. This batch recorded a bulk density of 0.34 g/mL, meeting the specification of ≥0.33 g/mL.
Tapped density measures the density after the powder container has been mechanically tapped and the particles have settled. The recorded tapped density was 0.62 g/mL, meeting the requirement of ≥0.60 g/mL. Both tests were performed according to USP <616>.
Bulk and tapped density are important for estimating drum volume, capsule filling, tablet compression, hopper feeding and powder blending. They also help formulators assess how much the powder may settle during transportation and processing. Because resveratrol can be supplied in standard or micronized grades, density and flow characteristics should be reviewed together with particle size for each formulation.
Particle Size, Moisture and Ash
The particle-size specification requires at least 95% through an 80-mesh sieve. This batch achieved 100.0% through 80 mesh according to ChP <0982>, supporting consistent blending and downstream processing.
Water content was only 0.07%, substantially below the maximum limit of 0.50%, using USP <921>. Low moisture helps support powder stability, storage performance and reduced risk of caking. Ash content was 0.10%, compared with a specification of ≤0.50%, according to ChP <2302>.
Residual Solvents
Residual ethanol was tested by gas chromatography, or GC. The result was 293 ppm, well below the specification of ≤1,000 ppm. Residual solvent control is important because ethanol may be used during purification, crystallization or processing. The low result demonstrates effective solvent removal during concentration and drying.
Heavy Metal Testing
Total heavy metals were controlled to ≤10 mg/kg, with the tested batch reporting <10 mg/kg according to ChP <0821>. Individual elemental contaminants were tested by ICP-MS, a sensitive analytical technique used for trace metal measurement.
The specifications were:
- Lead: ≤0.5 mg/kg
- Arsenic: ≤1.0 mg/kg
- Mercury: ≤0.1 mg/kg
- Cadmium: ≤1.0 mg/kg
All four individual heavy metal results conformed to their respective limits. These controls are important for dietary supplement brands, contract manufacturers and distributors sourcing high-purity resveratrol ingredients.
Microbiological Quality
The batch recorded <10 CFU/g for both total plate count and yeast and mold. Coliforms were <0.3 MPN/g, while Escherichia coli, Salmonella, Staphylococcus aureus and Pseudomonas aeruginosa were not detected.
Testing followed recognized methods including USP <2021>, USP <2022>, USP <62> and GB 4789.3. These results demonstrate strong microbiological control for bulk dietary supplement ingredient applications.
International Quality and Third-Party Verification
The COA uses recognized analytical methods including HPLC, GC, ICP-MS, USP, Chinese Pharmacopoeia and GB microbiological procedures. The batch conclusion confirms compliance with ProVita Biotech’s enterprise specifications. Batch-specific COAs, supporting quality documents and independent third-party testing can be provided or arranged according to customer and destination-market requirements.
ProVita Biotech prioritizes ingredient identity, potency, impurity control, safety and batch consistency for dietary supplement manufacturers, contract manufacturers and ingredient distributors. Each shipment is released only after quality control and quality assurance review.
Certificate of Analysis
| Test Item | Specification | Batch Result | Test Method |
|---|---|---|---|
| Product name | Resveratrol | Resveratrol | Internal identification |
| Product code | 111 | 111 | Internal record |
| Batch number | N/A | 111D2607131 | Batch record |
| Manufacture date | N/A | 2026-07-13 | Batch record |
| Expiration date | N/A | 2028-07-12 | Batch record |
| Packaging | 25 kg/drum | 25 kg/drum | Packaging record |
| Appearance | Off-white powder | Off-white powder | Sensory analysis |
| Particle size | ≥95% through 80 mesh | 100.0% | ChP <0982> |
| Bulk density | ≥0.33 g/mL | 0.34 g/mL | USP <616> |
| Tapped density | ≥0.60 g/mL | 0.62 g/mL | USP <616> |
| Water content | ≤0.50% | 0.07% | USP <921> |
| Ash | ≤0.50% | 0.10% | ChP <2302> |
| Residual ethanol | ≤1,000 ppm | 293 ppm | GC |
| Purity | ≥99.0% | 99.90% | HPLC |
| Assay | ≥99.0% | 99.60% | HPLC |
| Maximum single impurity | ≤0.10% | <0.01% | HPLC |
| Total impurities | ≤0.50% | <0.01% | HPLC |
| Total heavy metals | ≤10 mg/kg | <10 mg/kg | ChP <0821> |
| Lead | ≤0.5 mg/kg | Conforms | ICP-MS |
| Arsenic | ≤1.0 mg/kg | Conforms | ICP-MS |
| Mercury | ≤0.1 mg/kg | Conforms | ICP-MS |
| Cadmium | ≤1.0 mg/kg | Conforms | ICP-MS |
| Yeast and mold | ≤100 CFU/g | <10 CFU/g | USP <2021> |
| Total plate count | ≤1,000 CFU/g | <10 CFU/g | USP <2021> |
| Coliforms | <0.3 MPN/g | <0.3 MPN/g | GB 4789.3 |
| Escherichia coli | Absent in 10 g | Not detected | USP <2022> |
| Salmonella spp. | Absent in 10 g | Not detected | USP <2022> |
| Staphylococcus aureus | Absent in 10 g | Not detected | USP <2022> |
| Pseudomonas aeruginosa | Absent in 1 g | Not detected | USP <62> |
| Storage | Keep tightly closed and store in a dry place | Conforms | Storage specification |
| Final conclusion | Conform with enterprise specifications | Conforms | QC and QA review |
The values above are batch-specific and should not be presented as guaranteed results for every future shipment. Commercial specifications remain the applicable release criteria.
Application
Fermented resveratrol is widely used in dietary supplements, healthy-aging formulas, cardiovascular support products, antioxidant blends, functional foods, beverages, sports nutrition, beauty-from-within products, and cosmetic formulations. Its high trans-resveratrol content, consistent purity, and customizable particle size make it suitable for capsules, tablets, gummies, powders, liquid supplements, liposomal systems, and topical products.
Dietary Supplements
Fermentation-Derived Trans-Resveratrol 99% Powder is commonly used in capsules, tablets, gummies, and powdered supplements for antioxidant support, healthy aging, cellular health, and cardiovascular wellness. Its high purity helps manufacturers achieve accurate dosage and consistent finished-product specifications.
Functional Foods and Beverages
Fermented resveratrol can be added to functional drinks, nutrition powders, wellness sachets, and fortified foods. Micronized or liposomal resveratrol is often preferred for applications requiring improved dispersion, formulation flexibility, or enhanced delivery.
Cosmetics and Beauty Supplements
Trans-resveratrol is used in anti-aging skincare, antioxidant creams, serums, and beauty-from-within supplements. Its antioxidant properties make it suitable for formulations designed to support skin appearance and help protect against oxidative stress.
Fermentation-Derived Trans-Resveratrol 99% Manufacturing Process
ProVita Biotech manufactures Fermentation-Derived Trans-Resveratrol 99% Powder through a controlled microbial fermentation and purification process. Unlike Japanese knotweed extract, the production does not depend on variable botanical raw materials. The complete process includes fermentation, pretreatment, plate filtration, solid extraction, concentration, crystallization, resolvation, chromatographic decolorization, drying and packaging.
1. Controlled Microbial Fermentation
Selected fermentation strains are cultivated under controlled temperature, pH, nutrient and oxygen conditions. The fermentation stage produces trans-resveratrol from defined fermentation substrates and helps maintain consistent active-ingredient content between production batches.
2. Pretreatment
After fermentation, the fermentation broth undergoes pretreatment to stabilize the material and prepare it for downstream separation. Process conditions are carefully controlled to protect the trans configuration and reduce unwanted fermentation byproducts.
3. Plate Filtration
Plate filtration separates microbial biomass and suspended solids from the fermentation liquid. This step produces a clearer process stream and improves the efficiency of subsequent extraction and purification.
4. Solid Extraction
The resveratrol-containing fraction is recovered through solid extraction. Extraction parameters are optimized to maximize trans-resveratrol recovery while controlling residual fermentation materials and process-related impurities.
5. Concentration and Primary Crystallization
The extracted solution is concentrated to increase the trans-resveratrol content. Controlled crystallization then separates resveratrol crystals from soluble impurities, residual salts and other fermentation components.
6. Resolvation
The crude crystals are redissolved under controlled conditions. Resolvation allows further purification and prepares the material for chromatographic decolorization and secondary crystallization.
7. Chromatographic Decolorization
Chromatographic decolorization removes pigments, trace organic compounds and other color-forming impurities. This process helps produce a consistent white to off-white crystalline powder with a clean impurity profile.
8. Secondary Concentration and Crystallization
The purified solution undergoes another concentration and crystallization cycle. This step increases product purity and supports the final specification of at least 99.0% trans-resveratrol by HPLC.
9. Controlled Drying
The purified crystals are dried under controlled temperature and moisture conditions. Drying reduces water content and residual processing solvents while protecting product stability and preventing unnecessary degradation.
10. Milling, Micronization and Sieving
After drying, the powder can be milled and sieved to achieve the required particle size. Standard material can be supplied through an 80-mesh sieve, while customized micronized trans-resveratrol powder and different mesh sizes are available for capsule, tablet, gummy, powder blend and liposomal formulations.
11. Quality Control and Packaging
Each batch is tested for appearance, particle size, bulk density, tapped density, moisture, ash, HPLC assay, HPLC purity, maximum single impurity, total impurities, residual ethanol, heavy metals and microbiological quality. Testing methods include HPLC, gas chromatography, ICP-MS, USP procedures and Chinese Pharmacopoeia methods.
A representative production batch achieved 99.90% HPLC purity, 99.60% HPLC assay, <0.01% maximum single impurity, <0.01% total impurities, 0.07% water content and 293 ppm residual ethanol. The same batch also met the established limits for lead, arsenic, mercury, cadmium and microbiological contaminants.
The finished Fermentation-Derived Trans-Resveratrol 99% Powder is packed in sealed double polyethylene liners inside 25 kg fiber drums. Batch-specific COAs, quality documentation and independent third-party testing can be provided according to customer and destination-market requirements.
Through controlled fermentation, multiple purification stages and comprehensive analytical testing, ProVita Biotech delivers high-purity bulk trans-resveratrol powder with consistent assay, low impurities and reliable batch-to-batch quality for dietary supplement manufacturers, contract manufacturers and ingredient distributors.
Trans-Resveratrol Benefits
Fermentation-Derived Trans-Resveratrol 99% Powder provides a standardized source of trans-resveratrol for antioxidant, healthy-aging, cardiovascular, metabolic and cognitive-support supplements. Its high purity and consistent potency make it suitable for capsules, tablets, gummies, powders and advanced delivery systems.
- Antioxidant and cellular protection: Trans-resveratrol helps support the body’s antioxidant defenses and protect cells from oxidative stress.
- Healthy aging support: Resveratrol is widely researched for its role in cellular stress-response and energy-regulation pathways associated with healthy aging. It should not be presented as proven to extend human lifespan.
- Cardiovascular health: Human trials suggest that resveratrol supplementation may support endothelial function, circulation and healthy blood-vessel responses, although results vary by dose and study population.
- Metabolic wellness: Some clinical studies have reported improvements in insulin sensitivity and glucose or lipid metabolism, particularly in selected metabolic-health populations. Other trials found no significant benefit, so disease-treatment claims should be avoided.
- Brain and cognitive support: Preliminary human research suggests that resveratrol may support cerebral blood flow and certain aspects of memory or cognitive performance, but findings remain inconsistent.
- Healthy inflammatory response: Trans-resveratrol is commonly included in antioxidant formulas designed to support a balanced inflammatory response and overall cellular wellness.
- Standardized active content: A 99% HPLC specification helps supplement manufacturers deliver accurate trans-resveratrol dosage, consistent potency and reliable finished-product quality.
- Clean fermentation-derived source: Fermented trans-resveratrol provides an alternative to Japanese knotweed extract, with controlled production, consistent batch quality and reduced dependence on variable botanical raw materials.
- Flexible formulation options: Standard, micronized and liposomal resveratrol grades can support capsules, tablets, gummies, powdered supplements and liquid or advanced-delivery formulations.
Where to buy bulk Fermentation-Derived Trans-Resveratrol Powder?
ProVita Biotech Co., Ltd. is a leading Fermentation-Derived Trans-Resveratrol Powder supplier in China, providing resveratrol 99, pure resveratrol, powdered resveratrol and resveratrol bulk powder for dietary supplements, functional nutrition and cosmetic formulations. As an experienced resveratrol manufacturer and resveratrol powder manufacturer, we support bulk and wholesale orders, competitive resveratrol powder price, free samples, custom packaging and international shipment.
Every batch is tested for identity, HPLC assay and purity, maximum single impurity, total impurities, particle size, moisture, bulk density, tapped density, microbial contaminants, heavy metals and residual solvents. Raw materials are also evaluated for allergens and relevant contaminants. Herbal ingredients are tested for pesticide residues, while essential fatty acids and fish oils are tested for dioxins, furans, PCBs and other contaminants. Batch-specific COAs and third-party testing can be provided, together with relevant GMP, Kosher, Halal and quality certificates according to customer and destination-market requirements.
ProVita supplies standard and micronized resveratrol powder with custom mesh sizes, as well as liposomal resveratrol and water-soluble resveratrol solutions for advanced formulations. OEM services include resveratrol capsules, resveratrol pills, resveratrol tablets, resveratrol gummies, resveratrol liquid supplement, resveratrol liquid, nmn resveratrol gel and liposomal nmn and resveratrol products. We also support resveratrol cream, topical resveratrol and resveratrol face cream projects for cosmetic brands.
For buyers comparing fermentation-derived resveratrol ingredients with resveratrol extract, organic resveratrol powder, Pharmaceutical Grade materials or retail searches such as the ordinary resveratrol, ProVita provides clear source information, verified specifications and formulation support. Contact ProVita Biotech for a bulk quotation, free sample, COA, third-party test report or OEM proposal.
FAQs
Resveratrol can occur in trans and cis forms. Trans-resveratrol is the form most commonly specified in dietary supplements and research materials. For commercial sourcing, buyers should confirm that the assay specifically measures trans-resveratrol rather than total resveratrol.
Fermented resveratrol is produced from controlled fermentation instead of agricultural raw materials. This helps reduce variability associated with plant origin, harvesting conditions, pesticide residues and naturally occurring compounds such as emodin. Japanese knotweed extract may still be suitable for botanical products, but fermentation-derived trans-resveratrol is often selected when buyers require high purity and consistent specifications.
Purity describes the proportion of the main trans-resveratrol peak compared with other detected chromatographic peaks. Assay measures the actual amount of trans-resveratrol present in the powder according to the analytical method and calculation basis. Both values are important for potency, label claims and finished-product formulation.
Potential impurities may include cis-resveratrol, fermentation byproducts, residual starting materials, process intermediates, oxidation products, degradation compounds and unidentified trace chromatographic peaks. ProVita controls maximum single impurity to no more than 0.10% and total impurities to no more than 0.50%.
A representative batch recorded a bulk density of 0.34 g/mL, meeting the specification of at least 0.33 g/mL. Bulk density measures the mass of loose powder within a defined volume before compaction and is important for capsule filling, blending, drum capacity and production planning.
Tapped density measures powder density after the container has been mechanically tapped and the particles have settled. A representative ProVita batch achieved 0.62 g/mL against a minimum specification of 0.60 g/mL using USP <616>. Tapped density helps manufacturers evaluate powder settling, packaging volume, capsule filling and tablet-processing behavior.
Yes. ProVita supplies standard resveratrol powder and micronized resveratrol powder with customized particle-size requirements. Micronization increases powder surface area and may improve dispersion and dissolution, but the selected particle size should match the intended capsule, tablet, gummy, powder or liposomal formulation.
Trans-resveratrol is poorly soluble in water. For liquid supplements, beverages and other aqueous systems, manufacturers may require micronization, solubilizing excipients, emulsification or liposomal resveratrol. ProVita can support customized delivery and formulation projects.
Resveratrol can be absorbed from the gastrointestinal tract but is rapidly metabolized into conjugated forms, resulting in relatively low circulating levels of unchanged trans-resveratrol. Micronized powder, lipid-based systems and liposomal delivery are commonly evaluated to improve dissolution, dispersion or delivery performance.
Resveratrol is a specific stilbene polyphenol, while grape seed extract mainly contains proanthocyanidins and related flavonoids. Resveratrol is commonly used in healthy-aging and cellular wellness formulas, while grape seed extract is frequently used for antioxidant and vascular-support products. They can also be combined in multi-ingredient formulations.
They serve different formulation purposes. Resveratrol is a polyphenol associated with antioxidant and cellular stress-response support, while NMN is a precursor used in NAD-related formulations. The better option depends on the product positioning, target consumer, dosage, regulatory market and available stability data. Some healthy-aging products combine both ingredients.
Berberine and resveratrol can be combined in metabolic wellness formulations. Manufacturers should evaluate dosage, taste, color, capsule size, interaction with other ingredients and destination-market requirements. Finished-product claims should be supported by appropriate evidence and regulatory review.
ProVita supplies bulk powder and supports OEM manufacturing for resveratrol capsules, tablets, pills, gummies, liquid supplements, powder blends, liposomal resveratrol and customized combination formulas. Private-label packaging and contract manufacturing are also available.
Vegetarian capsule options are available using vegan-friendly HPMC shells. These can be produced without animal gelatin. Excipients, flow agents, fillers and preservatives depend on the final formulation and customer requirements, so the complete ingredient list should be confirmed before production.
Yes. Each commercial batch is tested for identity, HPLC assay, HPLC purity, impurities, particle size, moisture, bulk density, tapped density, residual solvents, heavy metals and microbiological quality. Independent third-party testing can also be arranged according to customer or destination-market requirements.
Free evaluation samples may be available for qualified supplement manufacturers, contract manufacturers, distributors and formulation laboratories. Customers can request the sample together with the current specification, COA and quotation.
Yes. Independent testing can be arranged for identity, potency, heavy metals, residual solvents, microbiological contaminants, pesticide residues, PAHs, emodin and other customer-specified parameters. Testing scope, laboratory and acceptance limits should be agreed before shipment.