Fisetin Powder
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What is Fisetin?
Fisetin is a naturally occurring flavonoid with strong antioxidant and anti-inflammatory properties, widely recognized for its potential health benefits, particularly in promoting cellular health and longevity. It is commonly extracted from various botanical sources, including Rhus Cotinus Extract, Smoketree Extract, Cotinus Coggygria Extract, and Japanese Wax Tree Extract, all of which are rich in this bioactive compound. Fisetin is also known by other names such as 3,7,3′,4′-Tetrahydroxyflavone. Its CAS Number is 528-48-3, and its molecular formula is C15H10O6, with a molecular weight of 286.24 g/mol.
ProVita Biotech Co., Ltd. is a leading wholesale supplier of bulk fisetin powder in China, offering premium quality Fisetin extracted from natural sources to meet the needs of nutraceutical, pharmaceutical, and dietary supplement industries.
Fisetin 98% Powder COA
The Fisetin Powder (98%) offered by Shanghai ProVita Biotech Co., Ltd. is sourced from high-quality Rhus Cotinus Extract, Smoketree Extract, and Cotinus Coggygria Extract, derived from the branches and leaves of Rhus cotinus L. (synonym: Cotinus coggygria scop). Manufactured with cutting-edge technology supported by Bongelov™, the batch (B01240215) was produced on February 15, 2024, with an expiration date of February 14, 2026, ensuring a shelf life of two years. The fisetin content in this product is verified to meet a purity level of 98.21%, tested using External HPLC with Sigma R.S., ensuring compliance with industry standards.
The product appears as a fine yellow powder with characteristic odor and taste, confirmed through organoleptic analysis. It complies with stringent physical and chemical specifications, including particle size (NLT 95% passing 60 mesh) and bulk density requirements (loose: 0.22 g/ml, tapped: 0.42 g/ml). The moisture content is controlled, with a loss on drying value of 1.47% and an ash content of 0.09%, both within the specified limits. The fisetin powder is non-irradiated and tested to confirm the absence of residual solvents, pesticide residues, and contaminants, ensuring it complies with USP <467> and USP <561> standards.
Heavy metal testing confirms that the product is free from hazardous contamination, with levels of lead (0.029 mg/kg), arsenic (0.081 mg/kg), cadmium (0.011 mg/kg), and mercury (0.004 mg/kg) well below permissible limits, as tested by ICP-MS methods in accordance with USP <233>. Microbiological testing ensures the product is safe for consumption, with a total plate count (<10 cfu/g), yeast and mold (<10 cfu/g), and the absence of harmful microorganisms such as E. coli, Salmonella, and S. aureus, following USP <61> and USP <62> guidelines.
The fisetin powder is packaged in 20 kg fiber drums, with two plastic bags inside to protect the product from contamination, light, and moisture during storage and transportation. It should be stored in tightly sealed containers in a cool, dry place to maintain its stability and quality. This product is certified by international standards, including cGMP, GMP+, FSSC22000, HACCP, ISO22000, ISO9001, Halal, Kosher, USDA Organic, and Ecocert Organic Certified, making it suitable for use in nutraceutical, pharmaceutical, and dietary supplement industries. Each batch is thoroughly reviewed and approved by experienced professionals, guaranteeing premium quality and compliance with regulatory standards.
Application
Antioxidant
Fisetin is a powerful natural flavonoid that acts as a potent antioxidant, protecting cells from oxidative stress and free radical damage. Its ability to neutralize harmful molecules helps prevent cellular aging, supports overall health, and promotes a stronger immune system. Ideal for use in nutraceuticals and dietary supplements, fisetin is your ally for enhanced vitality and cellular protection.
Brain Health
Fisetin plays a crucial role in supporting brain health by protecting neurons from oxidative stress and reducing inflammation in the brain. Known for its neuroprotective properties, fisetin enhances memory, promotes cognitive function, and may reduce the risk of neurodegenerative conditions like Alzheimer’s disease. It’s a perfect ingredient for brain-boosting supplements and nootropic formulations.
Longevity
Fisetin is recognized as a natural senolytic compound. It helps to eliminate aging or damaged cells, rejuvenating tissues and promoting healthy aging. By reducing oxidative stress and inflammation, fisetin supports longevity and overall wellness, making it a key ingredient for anti-aging supplements and health optimization products.
Fisetin Powder Manufacturing Process
At Shanghai ProVita Biotech Co., Ltd., we specialize in producing high-purity Fisetin powder (98%) from natural botanical sources such as Rhus Succedanea Extract and Rhus Cotinus Extract. Our fisetin manufacturing process is meticulously designed, utilizing advanced techniques such as HPLC testing to ensure the highest levels of purity and quality. Below is a step-by-step overview of our standardized production process:
Step-by-Step Manufacturing Process
Raw Material Selection
Only premium-grade branches and leaves of Rhus Cotinus or Rhus Succedanea are carefully sourced to ensure high fisetin content and quality.Peeling, Cutting, and Crushing
The raw materials are peeled, cut, and crushed into smaller particles to optimize the extraction process and enhance yield.Continuous Countercurrent Extraction (Water)
The crushed material undergoes continuous countercurrent extraction using water maintained at a controlled temperature of 90–95°C. This method ensures the efficient extraction of fisetin while preserving its bioactive properties.Concentration
The extracted solution is concentrated to remove excess water and increase the fisetin content for subsequent processing.Filtration
The concentrated extract is filtered to eliminate impurities, producing a high-quality wet cake containing enriched fisetin.Quality Control (QC) Check
The wet cake undergoes a thorough QC check to ensure compliance with quality standards before further processing.Recrystallization (Ethanol & Water)
The wet cake is purified through recrystallization using a mixture of ethanol and water. This process is critical for increasing the fisetin purity to meet the target of 98%.Repeated Recrystallization
To achieve ultra-high purity, the recrystallization process is repeated multiple times. Each cycle enhances the removal of residual impurities and ensures a consistent final product.Re-filtration and Wet Cake Formation
After each recrystallization step, the material is filtered again, yielding a refined wet cake.Drying
The purified wet cake is dried under controlled conditions to form a fine powder. Specialized equipment ensures that the drying process retains the bioactive properties of fisetin.Milling and Screening
The dried material is milled and screened to produce a consistent, fine powder with a light yellow appearance.HPLC Testing
Every batch of fisetin powder undergoes rigorous High-Performance Liquid Chromatography (HPLC) testing to verify its purity (≥98%) and ensure compliance with industry standards. This step is crucial for confirming the absence of contaminants and guaranteeing product safety.Final QC/QA Release
Comprehensive Quality Control (QC) and Quality Assurance (QA) protocols are conducted on the final product to certify its purity, potency, and quality.Packaging
The 98% fisetin powder is carefully packaged in moisture-proof, airtight containers to maintain its stability and integrity during storage and transportation.
Key Features of ProVita Biotech’s Fisetin Powder
- Purity Guaranteed: ≥98%, verified by HPLC analysis.
- Appearance: Light yellow, fine powder.
- Botanical Source: Extracted from Rhus Cotinus and Rhus Succedanea.
- Applications: Ideal for use in nutraceuticals, dietary supplements, and pharmaceuticals.
As a leading wholesale fisetin bulk powder supplier in China, Shanghai ProVita Biotech Co., Ltd. is committed to delivering premium-quality fisetin powder with unmatched purity and safety. Our state-of-the-art manufacturing facilities and adherence to GMP standards ensure that we provide the best fisetin powder to meet the needs of our global clients in the health and wellness industry. Contact us for bulk orders and customized packaging solutions.
Fisetin Benefits
Powerful Antioxidant Properties
Fisetin is a potent flavonoid that helps neutralize free radicals, reducing oxidative stress and preventing cellular damage. This benefit supports overall cellular health and protects the body against aging and chronic diseases caused by oxidative stress.Anti-Inflammatory Effects
Fisetin has strong anti-inflammatory properties, helping to reduce inflammation in the body. This makes it beneficial for managing conditions associated with chronic inflammation, such as arthritis, cardiovascular diseases, and neuroinflammation.Supports Brain Health and Cognitive Function
Fisetin promotes brain health by protecting neurons from damage, improving memory, and enhancing cognitive function. Studies suggest it may help prevent neurodegenerative conditions like Alzheimer’s disease and Parkinson’s disease by reducing oxidative stress and inflammation in the brain.Senolytic Activity for Healthy Aging
Fisetin is recognized as a natural senolytic compound, meaning it helps eliminate senescent (aging or damaged) cells from the body. By removing these dysfunctional cells, fisetin promotes tissue rejuvenation, supports longevity, and enhances overall health.Improves Cardiovascular Health
Fisetin helps maintain healthy blood vessels by reducing oxidative stress and inflammation, which are key factors in cardiovascular diseases. It also supports healthy cholesterol levels and may improve blood flow.Supports Healthy Blood Sugar Levels
Fisetin has been found to improve insulin sensitivity and regulate blood sugar levels, making it beneficial for managing metabolic health and preventing diabetes-related complications.Anti-Cancer Properties
Fisetin exhibits anti-cancer effects by inducing apoptosis (programmed cell death) in cancer cells, inhibiting tumor growth, and preventing the spread of cancer. It has shown promise in research for cancers such as breast, prostate, and colon cancer.Skin Health and Protection
Fisetin helps protect the skin from UV-induced damage and promotes collagen production, supporting skin elasticity and reducing the signs of aging. Its antioxidant and anti-inflammatory properties contribute to a healthier, more youthful complexion.Immune System Support
By reducing inflammation and oxidative stress, fisetin strengthens the immune system and supports the body’s natural defense mechanisms.Potential for Eye Health
Fisetin may also benefit eye health by protecting retinal cells from oxidative damage, which can contribute to conditions like age-related macular degeneration (AMD) and cataracts.
Overall, fisetin is a versatile flavonoid with numerous health benefits, particularly in promoting healthy aging, brain health, and metabolic balance. These benefits make it an increasingly popular choice in the nutraceutical and dietary supplement industries.
Where to buy Fisetin bulk powder?
Looking for premium fisetin bulk powder for sale? ProVita Biotech Co., Ltd. is a trusted supplier and manufacturer, offering 98% pure fisetin powder extracted from Rhus Cotinus. As a leading wholesale fisetin supplier, we provide competitive pricing, bulk quantities, and customizable packaging directly from our GMP-certified manufacturing facility.
Our fisetin powder is rigorously tested by HPLC for purity and quality, making it ideal for nutraceuticals, pharmaceuticals, and dietary supplements. We also offer a free sample to ensure customer satisfaction. For reliable supply and exceptional quality, choose ProVita Biotech for your wholesale fisetin needs. Contact us today to place an order!
FAQs
Fisetin is commonly derived from natural plant sources, including:
- Rhus Cotinus (Smoketree)
- Cotinus Coggygria
- Rhus Succedanea
These plants are rich in fisetin and are widely used for extraction.
Fisetin powder is available in varying purity levels to meet different application needs:
- 20%-50% Fisetin: Typically used for general antioxidant applications.
- 95%-98% Fisetin: High-purity powder ideal for advanced formulations in anti-aging, brain health, and pharmaceutical products.
Fisetin powder is manufactured through a standardized process that includes:
- Peeling, cutting, and crushing the raw material (e.g., Rhus Cotinus).
- Continuous Countercurrent Extraction using water at 90–95°C.
- Concentration and filtration to remove impurities.
- Recrystallization with ethanol and water for high-purity fisetin.
- Drying, milling, and screening to produce a fine yellow powder.
- HPLC testing to verify purity and quality.
Fisetin has moderate bioavailability, as the body does not easily absorb it in its natural form. To enhance its bioavailability, it is often combined with delivery systems like liposomes, nanoparticles, or taken alongside fats.
Fisetin powder is tested using HPLC analysis to verify its purity (up to 98%) and ensure it meets industry standards. It is also tested for heavy metals, microbiological contaminants, and pesticide residues to ensure safety.
Yes, the sample is free of charge. You can use your own courier account to arrange for collection, or we can ship it for you with the freight cost covered on your side. Additionally, the shipping cost will be deducted from your bulk order payment.
We generally do not have a strict Minimum Order Quantity (MOQ) requirement. Our standard packaging is 25kg per drum, making 25kg an ideal starting point. Smaller quantities, such as 10kg or other amounts, are also available, but please note that the unit cost may increase slightly for smaller orders. Feel free to contact us to discuss your specific requirements.
Yes, we have branches and warehouses in key locations worldwide: California (USA), Paris (Europe), Singapore (Asia), Shanghai (China), and Chestiville (Australia).