L-5-Methyltetrahydrofolate Calcium Powder
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What is L-5-Methyltetrahydrofolate Calcium?
L-5-Methyltetrahydrofolate Calcium (CAS Number: 151533-22-1) is the calcium salt form of L-5-methyltetrahydrofolate (L-5-MTHF), the bioactive form of folate, which plays a crucial role in the body’s methylation processes and the synthesis of DNA. It is commonly referred to by other names, including Calcium L-methylfolate and (6S)-5-Methyltetrahydrofolate Calcium. Its molecular formula is C20H27CaN7O6, with a molecular weight of approximately 499.57 g/mol. This compound is primarily derived from botanical sources such as spinach, kale, and other green leafy vegetables, as well as some fruits. L-5-MTHF Calcium appears as a white to off-white powder and is highly bioavailable, meaning it can be readily absorbed and utilized by the body without the need for conversion by the liver. It is widely used in dietary supplements for promoting healthy neural tube development, reducing homocysteine levels, and supporting cardiovascular and cognitive health. Provita Biotech is a leading bulk L-5-Methyltetrahydrofolate Calcium Powder supplier in China, providing high-quality products for the nutraceutical and supplement industries.
l-5-methyltetrahydrofolate vs l-methylfolate
When choosing between L-5-Methyltetrahydrofolate (L-5-MTHF) and L-Methylfolate, it’s important to understand their differences in chemical composition, bioavailability, potency, and other key factors. L-5-Methyltetrahydrofolate is the bioactive form of folate in the body and is more bioavailable than L-Methylfolate, making it the preferred choice for many individuals seeking folate supplementation. The following table outlines key differences between these two compounds to help you decide which one is better suited for your needs.
| Category | L-5-Methyltetrahydrofolate (L-5-MTHF) | L-Methylfolate |
|---|---|---|
| Chemical Name | L-5-Methyltetrahydrofolate Calcium (or 5-MTHF) | L-Methylfolate |
| CAS Number | 151533-22-1 | 67763-96-6 |
| Potency | Higher potency due to its bioactive form that is ready to use by the body | Lower potency, requires conversion to active form in the body |
| Bioavailability | Very high bioavailability, directly usable by the body | Moderate bioavailability, may require metabolic conversion |
| Specifications | Pure form, high solubility, often available as the calcium salt | May come in various salt forms such as glucosamine, but less stable |
| Pricing | Generally more expensive due to high bioavailability and purity | Less expensive but may require higher doses or conversion |
| Benefits | Promotes healthy neural tube development, reduces homocysteine, supports cardiovascular health, and improves mental clarity | Supports overall folate function, especially for people with MTHFR mutations |
| Popularity | Highly popular in bioactive supplements due to direct use by the body | Widely used, but less favored by individuals with folate conversion issues |
| Usage in Supplements | Often included in premium-quality supplements for enhanced effectiveness | Commonly used in standard folate supplements, especially for general folate supplementation |
| Stability | More stable in higher concentrations | Less stable than L-5-MTHF and may degrade over time in some conditions |
| MTHFR Mutations | Particularly beneficial for individuals with MTHFR gene mutations (which impair folate metabolism) | Less effective for people with MTHFR mutations due to the need for metabolic conversion |
L-5-Methyltetrahydrofolate (L-5-MTHF) is generally the superior option compared to L-Methylfolate due to its higher bioavailability, potency, and stability. It is directly usable by the body, making it ideal for individuals with MTHFR mutations or those who need higher folate bioavailability. While L-Methylfolate is still commonly used and more affordable, L-5-MTHF is the more effective choice, especially for specific health applications like neural tube development, cardiovascular support, and cognitive health. If you are looking for higher-quality folate supplementation and a product that is ready to work immediately, L-5-Methyltetrahydrofolate is the better choice. Provita Biotech, as a leading supplier of bulk L-5-Methyltetrahydrofolate, provides premium-quality products suited to the needs of the nutraceutical industry.
Application
Prenatal Health
L-5-Methyltetrahydrofolate Calcium is essential for prenatal health, supporting the proper development of the neural tube in fetuses. It is commonly used in prenatal supplements to reduce the risk of neural tube defects and ensure optimal folate levels during pregnancy.
Brain Health
L-5-Methyltetrahydrofolate Calcium supports brain function by enhancing neurotransmitter synthesis and reducing oxidative stress. It is commonly used in supplements for cognitive support, memory enhancement, and mental health management, especially for individuals with MTHFR gene mutations.
Cardiovascular Health
By lowering homocysteine levels in the blood, L-5-Methyltetrahydrofolate Calcium helps protect cardiovascular health. Elevated homocysteine is linked to a higher risk of heart disease, and this bioactive folate form is widely included in supplements targeting heart health.
L-5-Methyltetrahydrofolate Calcium powder Manufacturing Process
The manufacturing process of L-5-Methyltetrahydrofolate Calcium Powder is a complex and precise multi-step procedure designed to ensure a final product with 99% purity that meets third-party lab quality standards. Below is a detailed description of the process based on the provided flowcharts and general knowledge:
Preparation of the Starting Material (Folic Acid):
- Purified water and folic acid are combined in a reactor.
- The reaction is initiated, creating the base material for subsequent steps.
Reduction Reaction:
- Liquid sodium hydroxide and sodium borohydride are added to the reactor to reduce the folic acid.
- This reduction step converts folic acid into a critical intermediate.
First Crystallization:
- Hydrochloric acid and p-toluenesulfonic acid are introduced to the reaction mixture, followed by crystallization.
- The mixture is filtered, yielding Intermediate 1.
Purification through Repeated Crystallization:
- Intermediate 1 undergoes further crystallization and filtration processes with purified water and p-toluenesulfonic acid to enhance purity, producing Intermediate 2 and subsequently Intermediate 3.
Methylation and Further Reduction:
- Intermediate 3 is reacted with formaldehyde and liquid sodium hydroxide in a reactor to introduce a methyl group, followed by reduction using sodium borohydride.
- Hydrochloric acid is added, leading to crystallization and filtration to yield Intermediate 4.
Formation of Calcium Salt:
- Intermediate 4 is dissolved in purified water and reacted with calcium chloride in a reactor.
- The solution undergoes crystallization and filtration, resulting in Intermediate 5.
Final Recrystallization:
- Intermediate 5 is dissolved in purified water and recrystallized to achieve the desired high-purity product.
- Filtration is performed to remove impurities.
Quality Assurance and Drying:
- The final product undergoes a full quality test, including a third-party lab analysis, to ensure it meets industry standards for purity (99%) and quality.
- After passing quality control, the product is carefully dried to obtain the final L-5-Methyltetrahydrofolate Calcium Powder.
Provita Biotech utilizes advanced manufacturing technology and rigorous quality controls, making it the leading supplier of bulk L-5-Methyltetrahydrofolate Calcium Powder in China.
L-5-Methyltetrahydrofolate Calcium powder Benefits
1. Supports Prenatal Health
L-5-Methyltetrahydrofolate Calcium is essential for healthy fetal development, particularly in supporting neural tube formation during pregnancy. Its bioactive form ensures superior absorption and effectiveness in reducing the risk of neural tube defects, making it a key ingredient in prenatal supplements.
2. Improves Cardiovascular Health
This compound helps regulate homocysteine levels, a key marker for heart health. Elevated homocysteine levels are linked to cardiovascular issues, and L-5-Methyltetrahydrofolate Calcium aids in reducing these levels, thereby promoting a healthier heart and vascular system.
3. Enhances Cognitive Function
L-5-Methyltetrahydrofolate Calcium plays a vital role in neurotransmitter synthesis, improving brain function, memory, and focus. It has been shown to support mental clarity and cognitive health, especially in individuals with folate metabolism disorders.
4. Suitable for Individuals with MTHFR Gene Mutation
Unlike synthetic folic acid, L-5-Methyltetrahydrofolate Calcium does not require enzymatic conversion in the body. This makes it ideal for individuals with MTHFR (methylenetetrahydrofolate reductase) gene mutations, who often struggle to metabolize folic acid effectively.
5. Boosts Energy and Cellular Health
This bioactive form of folate supports DNA synthesis and repair, aiding cellular health and function. By fueling cellular processes, it also helps combat fatigue and enhances overall energy levels.
6. Supports Mental Health
L-5-Methyltetrahydrofolate Calcium is commonly used as part of therapeutic regimens for mood disorders such as depression. Its role in neurotransmitter production, including serotonin and dopamine, makes it effective in supporting emotional well-being.
7. Promotes Healthy Aging
By aiding in DNA repair, reducing oxidative stress, and supporting overall cellular health, L-5-Methyltetrahydrofolate Calcium helps slow down the aging process and promotes longevity.
8. Improves Skin Health
The compound’s role in cellular regeneration and repair also supports healthy skin by promoting collagen synthesis and reducing inflammation, leading to smoother and healthier-looking skin.
L-5-Methyltetrahydrofolate Calcium Powder is a versatile and bioavailable form of folate, providing comprehensive health benefits for various applications in prenatal care, cardiovascular health, cognitive function, and more. As a trusted bulk supplier, Provita Biotech ensures top-quality L-5-Methyltetrahydrofolate Calcium Powder to meet the highest industry standards.
Where to buy L-5-Methyltetrahydrofolate Calcium bulk powder?
Where to Buy L-5-Methyltetrahydrofolate Calcium Bulk Powder?
Looking for high-quality L-5-Methyltetrahydrofolate Calcium Powder in bulk? Provita Biotech, a trusted supplier in China, offers 99% pure powder backed by third-party lab testing. Ideal for dietary supplements, nutraceuticals, and pharmaceuticals, our product ensures superior bioavailability and effectiveness.
With competitive pricing, reliable shipping, and strict quality control, Provita Biotech is the preferred choice for bulk buyers worldwide. Contact us today for a customized quote and fast delivery!
FAQs
Unlike folic acid, L-5-Methyltetrahydrofolate Calcium is the bioactive form of folate and does not require conversion by the body, making it more effective and suitable for individuals with MTHFR gene mutations.
Yes, it is ideal for individuals with MTHFR mutations as it bypasses the metabolic conversion required by folic acid, ensuring effective absorption.
Yes, the sample is free of charge. You can use your own courier account to arrange for collection, or we can ship it for you with the freight cost covered on your side. Additionally, the shipping cost will be deducted from your bulk order payment.
We generally do not have a strict Minimum Order Quantity (MOQ) requirement. Our standard packaging is 25kg per drum, making 25kg an ideal starting point. Smaller quantities, such as 10kg or other amounts, are also available, but please note that the unit cost may increase slightly for smaller orders. Feel free to contact us to discuss your specific requirements.
Yes, we have branches and warehouses in key locations worldwide: California (USA), Paris (Europe), Singapore (Asia), Shanghai (China), and Chestiville (Australia).