L-Citrulline DL-Malate 2:1 Powder
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What is L-Citrulline DL-Malate?
L-Citrulline DL-Malate is a compound formed by combining the non-essential amino acid L-Citrulline with DL-Malate (a salt of malic acid), with CAS number 57654-58-1. Also known as Citrulline Malate or CM, this ingredient has a molecular formula of C10H17N3O8 and a molecular weight of 307.26 g/mol. It naturally occurs in watermelons, cucumbers, and pumpkins, though commercial versions are typically synthesized for consistency. L-Citrulline DL-Malate is most commonly available in a 2:1 ratio (two parts citrulline to one part malate), though custom ratios can be formulated based on specific requirements. It appears as a white to off-white crystalline powder with excellent bioavailability, as the malate component enhances the absorption and utilization of citrulline in the body, leading to improved nitric oxide production and exercise performance. Provita Biotech stands as the leading bulk L-Citrulline DL-Malate powder supplier in China, providing high-quality, pharmaceutical-grade product to global markets.
L-Citrulline vs. L-Citrulline DL-Malate
When comparing L-Citrulline and L-Citrulline DL-Malate, the latter generally offers superior benefits for most applications. L-Citrulline DL-Malate provides enhanced bioavailability and absorption due to the malate component, which also contributes additional energy-producing benefits through its role in the Krebs cycle. While pure L-Citrulline offers higher citrulline content by weight, the 2:1 L-Citrulline DL-Malate formulation is more popular in sports nutrition due to its synergistic effects on exercise performance, reduced muscle soreness, and improved endurance. L-Citrulline DL-Malate also demonstrates better stability and typically provides more value despite its slightly higher price point. For athletic performance and overall effectiveness, L-Citrulline DL-Malate is generally the preferred choice, though pure L-Citrulline may be suitable for specific applications requiring the isolated amino acid.
| Feature | L-Citrulline | L-Citrulline DL-Malate |
|---|---|---|
| CAS Number | 372-75-8 | 57654-58-1 |
| Other Names | 2-Amino-5-(carbamoylamino)pentanoic acid | Citrulline Malate, CM |
| Molecular Formula | C₆H₁₃N₃O₃ | C₁₀H₁₇N₃O₈ |
| Molecular Weight | 175.19 g/mol | 307.26 g/mol |
| Appearance | White crystalline powder | White to off-white crystalline powder |
| Purity | Typically 98-99% | 98-99% (for the compound) |
| Bioavailability | Good | Enhanced (malate improves absorption) |
| Potency | Higher citrulline content by weight | Lower citrulline content by weight (66% in 2:1 ratio) but with added benefits from malate |
| Half-life | 1-2 hours | 1-2 hours (citrulline component) |
| Stability | Good | Better (more stable in various formulations) |
| Popularity | Common in pharmaceutical applications | More popular in sports nutrition and supplements |
| Pricing | Lower cost per gram | Slightly higher cost per gram |
| Main Benefits | Nitric oxide production, vasodilation, protein synthesis | Enhanced nitric oxide production, reduced muscle fatigue, improved energy production (from malate), better exercise performance |
| Solubility | Soluble in water | More soluble in water |
| Taste | Slightly bitter | More acidic and bitter (due to malate) |
| Usage in Supplements | Common dosage: 3-5g | Common dosage: 6-8g of 2:1 ratio |
| Energy Production | No direct effect | Malate contributes to Krebs cycle energy production |
| Muscle Soreness | Some reduction | Greater reduction due to malate component |
| Exercise Performance | Improves | Superior improvement |
| Clinical Applications | Hypertension, erectile dysfunction | Hypertension, erectile dysfunction, muscle recovery, fatigue reduction |
L-Citrulline DL-Malate COA
ProVita Biotech’s L-Citrulline DL-Malate (2:1) powder (Lot No. C610-202108318) demonstrates exceptional quality with a 99.1% total assay purity, containing 64.8% L-Citrulline and 34.3% DL-Malate as verified by liquid chromatography. The product meets stringent safety standards for heavy metals with results well below acceptable limits: lead <3ppm, arsenic <1ppm, cadmium <1ppm, mercury <0.1ppm, and total heavy metals <10ppm. Additional purity indicators include chloride <0.05%, ammonium <0.02%, and sulfate <0.020%. The powder shows minimal residual contaminants with 0.14% loss on drying and 0.04% residue on ignition. Microbial testing confirms the absence of E. Coli, Salmonella, Pseudomonas, and S. Aureus, with total plate count, yeast, molds, and coliforms all meeting specifications. The white crystalline powder exhibits a specific rotation of +16.9° and excellent solubility (99.3% transmittance), making this pharmaceutical-grade ingredient ideal for premium nutritional supplements and sports performance products.
Application
Sports Performance and Endurance
L-Citrulline DL-Malate is widely used in pre-workout supplements to enhance exercise performance and reduce muscle fatigue. It boosts nitric oxide production, leading to improved blood flow, oxygen delivery, and endurance. Athletes and fitness enthusiasts take it to maximize stamina and accelerate post-workout recovery.
Cardiovascular Health
This compound supports heart health by promoting vasodilation and healthy blood pressure levels. By increasing nitric oxide, L-Citrulline DL-Malate helps improve circulation, reducing strain on the heart and enhancing overall cardiovascular function. It is often included in heart health supplements to support vascular wellness.
Muscle Recovery and Fatigue Reduction
L-Citrulline DL-Malate plays a key role in reducing muscle soreness and enhancing ATP production, making it essential for post-exercise recovery. Its ability to flush out lactic acid and ammonia helps minimize muscle fatigue, allowing for quicker recovery and better performance in subsequent workouts.
L-Citrulline DL-Malate Powder Manufacturing Process
1. Raw Material Selection and Preparation
- L-Citrulline and Malic Acid (in a 2:1 ratio by weight) are sourced from approved suppliers and verified for identity, purity, and compliance with specifications.
- Both materials are transferred into a clean production area that meets or exceeds 300,000-class cleanliness standards.
2. Precise Weighing and Dispensing
- Operators carefully weigh the required amounts of L-Citrulline and Malic Acid according to the 2:1 ratio.
- Each batch typically targets a specific daily production quantity (e.g., 29.8 kg of L-Citrulline to 14.9 kg of Malic Acid, scaled as needed) to achieve the desired 2:1 stoichiometric balance.
3. Dry Blending
- The weighed raw materials are placed into a dedicated mixer or blender.
- Under controlled temperature and humidity conditions, the L-Citrulline and Malic Acid are blended thoroughly.
- This step forms L-Citrulline DL-Malate (2:1) via a dry reaction/blending process, ensuring a uniform, free-flowing powder with consistent particle size.
4. Sieving and Homogenization
- The blended powder is passed through a fine sieve (commonly 80-mesh or similar) to break up any agglomerates and ensure uniform particle size distribution.
- The sieved material is homogenized again to guarantee consistency across the entire batch.
5. Sampling and Quality Control
- Before final packaging, representative samples are taken for in-house and/or external laboratory testing.
- Analyses include purity (target ≥99%), heavy metals, microbial limits, and other quality parameters per international standards (e.g., USP, EP).
- Third-party labs may be used to validate the in-house results, confirming compliance and safety.
6. Final Packaging
- Once approved by Quality Control, the L-Citrulline DL-Malate (2:1) Powder is transferred into clean, food-grade or pharmaceutical-grade containers.
- Packaging occurs in a low-humidity, clean environment to prevent moisture uptake and preserve product stability.
- Each batch is labeled with lot numbers, manufacturing dates, and other required traceability data.
7. Finished Product Release
- The finished L-Citrulline DL-Malate (2:1) Powder undergoes a final review of all quality documents and test reports.
- Only after meeting all specifications is the product released for distribution.
- Typical batch sizes can yield up to 1000 kg of final product, each unit backed by a certificate of analysis demonstrating ≥99% purity.
L-Citrulline DL-Malate Benefits
- Boosts Nitric Oxide Production: L-Citrulline DL-Malate supports better blood flow and oxygen delivery, leading to stronger pumps and enhanced vascularity.
- Improves Exercise Endurance: By helping clear ammonia and lactic acid, it can delay fatigue and allow for more intense, longer workouts.
- Speeds Muscle Recovery: Enhanced circulation and reduced muscle soreness support faster post-workout repair and growth.
- Supports Peak Performance: Increased ATP production helps sustain energy levels and overall exercise output, making each training session more effective.
- Promotes Cardiovascular Health: Improved blood flow contributes to healthier blood pressure levels and cardiovascular function over time.
Where to buy L-Citrulline DL-Malate bulk powder?
ProVita Biotech is your trusted partner for L-Citrulline DL-Malate bulk powder, offering high-purity product verified by strict quality control and third-party testing. We cater to supplement brands, distributors, and manufacturers seeking reliable sourcing at competitive prices. Contact ProVita Biotech today to discuss your bulk volume requirements and experience our commitment to consistent quality and timely delivery.
FAQs
At ProVita Biotech, we provide both forms, but it's important to understand their distinction. L-Citrulline Malate specifically contains the L-isomer of malic acid, while L-Citrulline DL-Malate contains both D and L isomers of malic acid. Our L-Citrulline DL-Malate is more cost-effective while maintaining excellent bioavailability and is our most popular export product for sports nutrition formulations.
Based on our extensive research and customer feedback, L-Citrulline DL-Malate in a 2:1 ratio offers the optimal balance of effectiveness and value for most supplement applications. The malate component enhances absorption and provides additional energy-producing benefits through the Krebs cycle, making it superior to standalone L-Citrulline for performance enhancement formulations.
Our standard offering is a 2:1 ratio (two parts citrulline to one part malate), which is the industry standard and most research-supported formulation. However, as a leading manufacturer, we can customize ratios according to your specific formulation requirements, including 1:1 and 3:1 options with our flexible production capabilities.
ProVita Biotech employs a proprietary fermentation and synthesis process that ensures consistent high quality. Our manufacturing begins with premium raw materials, followed by controlled fermentation, precise compounding of L-Citrulline with DL-Malic acid, purification, testing, and finally micronization to ensure optimal particle size for maximum absorption and blending capabilities.
Our standard MOQ for L-Citrulline DL-Malate is 25kg for regular orders. However, we understand that new customers may wish to evaluate our product quality first, so we offer 1kg samples for testing purposes. For established partners with regular ordering patterns, we can negotiate flexible MOQ arrangements.
All ProVita Biotech ingredients come with comprehensive documentation including Certificate of Analysis (COA), HPLC chromatograms, heavy metal testing reports, and microbial testing results. Our facility is ISO 9001, HACCP, and GMP certified. We also provide Non-GMO certification, allergen statements, and BSE/TSE declarations upon request.
ProVita Biotech maintains a production capacity of 50 metric tons of L-Citrulline DL-Malate monthly. Standard lead time for bulk orders is 2-3 weeks after confirmation, but we maintain strategic inventory levels of our most popular ingredients to accommodate rush orders, sometimes shipping within 3-5 business days for existing customers.
As a leading Chinese manufacturer with global reach, we offer multiple shipping solutions including air freight, sea freight, and express courier services. We handle all export documentation, customs clearance assistance, and can ship under Incoterms FOB, CIF, or EXW according to your preference. Our logistics team specializes in temperature-controlled shipping to maintain product integrity.
Our L-Citrulline DL-Malate stands out for its exceptional purity (99%+), consistent particle size distribution, and superior flowability—critical factors for manufacturing efficiency. Our vertical integration model controls every production aspect, resulting in batch-to-batch consistency that our competitors struggle to match. Additionally, our material undergoes rigorous stability testing under various environmental conditions.
Yes, ProVita Biotech provides comprehensive private label and OEM services. We can develop custom formulations incorporating our premium L-Citrulline DL-Malate according to your specifications. Our services include formula development, stability testing, packaging design, and fulfillment solutions tailored to your brand requirements, with confidentiality guaranteed through our strict NDA protocols.
ProVita Biotech offers competitive tiered pricing based on order volume: 25-100kg, 100-500kg, 500-1000kg, and 1000kg+. As one of China's largest manufacturers, we provide transparent pricing that reflects economies of scale. Long-term supply agreements can secure additional discounts, and we offer price protection options to shield partners from market fluctuations.
Our L-Citrulline DL-Malate undergoes proprietary stabilization processes and is packaged in moisture-resistant, double-lined drums or bags. When stored properly at controlled temperature (below 25°C) and humidity (below 65%), our product maintains full potency for 36 months. We provide detailed storage guidelines and can assist with stability-indicating methodologies for your finished products.