L-Citrulline Powder
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What is L-Citrulline?
L-Citrulline (CAS No. 372-75-8) is a non-essential amino acid that plays a crucial role in the urea cycle and nitric oxide metabolism in the human body. Also known as 2-Amino-5-(carbamoylamino)pentanoic acid or (S)-2-Amino-5-ureidopentanoic acid, it has the molecular formula C₆H₁₃N₃O₃ with a molecular weight of 175.19 g/mol. L-Citrulline occurs naturally in watermelons (Citrullus lanatus), cucumbers, and other cucurbitaceae family plants, with watermelon being the richest botanical source. The commercial product typically appears as a white to off-white crystalline powder with specifications of ≥98.0% purity for pharmaceutical and nutritional supplement applications. Regarding bioavailability, L-Citrulline demonstrates superior absorption compared to L-Arginine, with approximately 80% bioavailability when taken orally, as it bypasses hepatic metabolism and effectively converts to L-Arginine in the kidneys. Provita Biotech stands as the leading bulk L-Citrulline powder supplier in China, offering high-quality pharmaceutical and food-grade L-Citrulline to global markets.
l-citrulline vs l-arginine
When comparing L-Citrulline and L-Arginine, L-Citrulline generally offers superior benefits for nitric oxide production due to its better bioavailability, longer half-life, and greater stability. While L-Arginine directly serves as a nitric oxide precursor, it undergoes significant first-pass metabolism in the liver, resulting in less efficient delivery to the bloodstream. L-Citrulline, on the other hand, bypasses this extensive liver metabolism and acts as a more effective “time-release” form of L-Arginine, as it converts to L-Arginine in the kidneys. For most performance and cardiovascular applications, L-Citrulline represents the better choice, though it typically comes at a higher price point. Many advanced supplements now feature L-Citrulline rather than L-Arginine for these reasons.
Can You Take L-Arginine and L-Citrulline Together?
Yes, L-Arginine and L-Citrulline can be taken together, and this combination may offer synergistic benefits. Many performance and cardiovascular supplements include both amino acids to capitalize on their complementary mechanisms. L-Citrulline provides sustained L-Arginine levels in the bloodstream, while direct L-Arginine supplementation can provide an immediate, though shorter-lived effect. This combination approach may optimize nitric oxide production better than either amino acid alone. However, individuals should consult healthcare professionals before combining supplements, particularly those with low blood pressure or taking medications for cardiovascular conditions.
| Feature | L-Citrulline | L-Arginine |
|---|---|---|
| CAS Number | 372-75-8 | 74-79-3 |
| Other Names | 2-Amino-5-(carbamoylamino)pentanoic acid; (S)-2-Amino-5-ureidopentanoic acid | (S)-2-Amino-5-guanidinopentanoic acid; (S)-2-Amino-5-guanidinovaleric acid |
| Molecular Formula | C₆H₁₃N₃O₃ | C₆H₁₄N₄O₂ |
| Molecular Weight | 175.19 g/mol | 174.20 g/mol |
| Appearance | White to off-white crystalline powder | White crystalline powder |
| Purity | ≥98.0% (pharmaceutical grade) | ≥98.5% (pharmaceutical grade) |
| Bioavailability | ~80% (superior oral bioavailability) | ~20% (poor oral bioavailability due to first-pass metabolism) |
| Potency | Moderate initially but higher sustained effect | High immediate effect but rapidly metabolized |
| Half-life | 1-2 hours (provides sustained arginine levels) | 1-2 hours (but effective duration shorter due to metabolism) |
| Stability | More stable in the body and in product formulations | Less stable, more susceptible to degradation |
| Popularity | Growing rapidly in sports nutrition and clinical applications | More established but declining in favor of citrulline |
| Pricing | Higher cost ($40-60/kg bulk) | Lower cost ($20-40/kg bulk) |
| Main Benefits | • More effective at increasing plasma arginine levels • Better for sustained nitric oxide production • Improved exercise performance • Enhanced vasodilation • Less GI distress | • Direct nitric oxide precursor • Immediate but shorter-lasting effects • Protein synthesis • Wound healing • Immune function support |
| Side Effects | Minimal; generally well-tolerated | More common: GI distress, diarrhea, nausea, low blood pressure |
| Conversion | Converts to L-arginine in the kidneys | Directly used or converted to nitric oxide |
| Natural Sources | Watermelon, cucumbers, squash | Nuts, seeds, meat, dairy products |
| Dosage Range | 3-10g daily (typically 6g for performance) | 3-6g daily (often divided doses) |
L-Citrulline Powder COA
Based on the Certificate of Analysis from ProVita Biotech Co., Ltd., their L-Citrulline powder (CAS No: 372-75-8) demonstrates exceptional quality with an assay purity of 99.2% (specification: 98.5-101.0%). The product contains minimal heavy metal contamination with iron, lead, cadmium, arsenic, and mercury all well below acceptable limits (<10ppm for most metals). Residual solvent testing shows chloride content <0.020%, ammonium <0.02%, and sulfate <0.020%. The white crystalline powder has a specific rotation of +26.2° and displays excellent solubility with a transmittance of 99.2%. The product has passed all microbial tests, showing negative results for E. Coli, Salmonella, Pseudomonas, and S. Aureus, with a pH of 6.1. Manufactured via fermentation process in China, this 1000KG batch (Lot No: C603-202411206) was tested on November 8, 2024, and remains stable until October 28, 2026 when stored in tight containers at controlled room temperature.
Application
Enhanced Exercise Performance
L-Citrulline is widely used to boost workout performance. By increasing nitric oxide levels, it improves blood flow and oxygen delivery to muscles, reducing fatigue and enhancing endurance. This makes it a favorite supplement for athletes and fitness enthusiasts looking to maximize their training results.
Cardiovascular Health Support
Known for its heart-friendly benefits, L-Citrulline helps maintain healthy blood pressure and promotes vascular function. Its ability to increase nitric oxide production supports improved circulation, making it a vital component in cardiovascular health supplements.
Improved Nitric Oxide Production
L-Citrulline is key to elevating nitric oxide in the body, which is essential for proper blood flow and overall cellular health. This application not only aids in muscle recovery but also supports metabolic efficiency and overall wellness, making it a versatile addition to modern health regimens.
L-Citrulline Powder Manufacturing Process
The manufacturing process of L-Citrulline Powder at ProVita Biotech Co., Ltd. begins with the use of L-Arginine Base and Zymophyte Enzyme as the primary raw materials. These components are combined with RO (Reverse Osmosis) water to create a solution, which is then carefully measured and mixed in a process called Burdening.
Next, the solution undergoes Transformation, where the enzymatic reaction converts L-Arginine into L-Citrulline. The transformed solution is then filtered to remove any impurities, followed by an Ion Exchange process to further purify the product.
The purified solution is concentrated to increase the L-Citrulline content, and then subjected to Fine Filtration to ensure the removal of any remaining particulates. The solution is then crystallized, and the resulting crystals are separated from the liquid through Centrifugal Separation. The mother solution is recycled to maximize efficiency and minimize waste.
The separated crystals are dried to remove residual moisture, and then sieved to achieve a uniform particle size. The semi-finished product undergoes a thorough inspection to ensure quality and consistency.
After passing the inspection, the product is temporarily stored before being mixed to ensure homogeneity. It then undergoes an Accent Inspection for Inner Package to verify its quality before being packaged in inner containers. The inner packages are then placed into outer packaging for additional protection.
The finished product undergoes a final inspection to confirm it meets the required standards, including 99% purity and compliance with international regulations. Once approved, the L-Citrulline Powder is warehoused, ready for distribution.
Throughout the process, ProVita Biotech ensures that the product meets stringent quality control measures, including third-party quality tests, to deliver a high-quality, reliable product to its customers.
L-Citrulline Benefits
- Supports Muscle Recovery: Speeds up muscle repair and reduces soreness after workouts.
- Enhances Muscle Growth: Boosts protein synthesis to promote lean muscle development.
- Improves Exercise Endurance: Reduces fatigue and helps maintain energy levels during prolonged physical activity.
- Prevents Muscle Breakdown: Helps preserve lean muscle mass during intense exercise or dieting.
- Promotes Fat Loss: Supports fat burning by preserving muscle and boosting metabolism.
- Quick Absorption: Instantly dissolves in water for faster digestion and quicker results.
- Convenient to Use: Easy to mix and consume during or after exercise for optimal performance.
Where to buy L-Citrulline bulk powder?
At ProVita Biotech, we offer premium-grade L-Citrulline bulk powder sourced directly from FDA-registered facilities. Our L-Citrulline bulk powder undergoes rigorous third-party testing for purity, ensuring every batch meets pharmaceutical-grade standards with a minimum 99% purity guarantee.
Purchasing Options
Purchase L-Citrulline bulk powder directly through our secure online portal in various quantities:
– 1kg L-Citrulline powder packages
– 5kg L-Citrulline bulk containers
– 25kg L-Citrulline wholesale options
– Custom bulk orders available for manufacturers
Quality Assurance
Each L-Citrulline bulk powder shipment includes:
– Certificate of Analysis (COA)
– Microbial testing documentation
– Heavy metals screening results
– Batch-specific purity verification
Contact our dedicated supplement formulation team today for L-Citrulline bulk powder pricing and availability or to request samples for evaluation.
FAQs
At ProVita Biotech, our L-Citrulline offers superior bioavailability compared to L-Arginine. Clinical studies indicate L-Citrulline is more effective as it bypasses hepatic metabolism, converting to L-Arginine in the kidneys. For ED formulations, our pharmaceutical-grade L-Citrulline demonstrates 30-40% higher plasma arginine levels than direct L-Arginine supplementation.
Our research indicates no significant interaction between L-Citrulline and methylene blue in formulations. Both compounds work through nitric oxide pathways, but through different mechanisms, making them compatible in combination products. We can provide stability testing documentation upon request.
These are entirely different compounds. Our L-Citrulline is a non-essential amino acid vital for the urea cycle and nitric oxide production. Cyclic citrullinated peptide (CCP) is an immunological marker used in rheumatoid arthritis testing, not a nutritional supplement ingredient.
Our L-Citrulline bulk powder shows peak plasma levels 1-2 hours after administration, with vascular effects lasting 4-6 hours in formulated products. This profile makes it ideal for pre-workout, cardiovascular, and men's health formulations requiring sustained nitric oxide production.
Our L-Citrulline is produced through controlled bacterial fermentation using non-GMO sources, followed by multi-stage purification including crystallization, filtration, and spray-drying. This proprietary process ensures consistent 99%+ purity with minimal heavy metal content.
Each batch includes comprehensive documentation: Certificate of Analysis (COA), Certificate of Origin, ISO 9001:2015 certification, FDA registration verification, allergen statements, BSE/TSE-free certification, and heavy metals analysis.
ProVita Biotech's L-Citrulline consistently tests at 99-99.5% purity using HPLC analysis. Each batch undergoes full spectrum testing for residual solvents, microbials, and heavy metals to ensure compliance with USP/EP standards.
Our standard MOQ is 25kg for regular clients, with 5kg sample options available for new formulation development. Volume discounts begin at 100kg+ with significant price advantages at 1MT and above.
We maintain 10MT of in-stock L-Citrulline for immediate shipment. Standard orders ship within 3-5 business days. Custom production runs typically require 3-4 weeks lead time, with expedited options available.
Current research does not support direct testosterone enhancement from L-Citrulline. However, its nitric oxide-boosting properties may complement testosterone-focused formulations by improving blood flow and exercise performance, creating synergistic benefits in men's health products.
Yes, our facility provides custom blending services for L-Citrulline with complementary ingredients like L-Arginine, pine bark extract, and beetroot extract. We can develop proprietary blends according to your specifications with full stability testing.
Our L-Citrulline demonstrates excellent stability (36+ months) in powder formulations, 24+ months in compressed tablets, and 18+ months in most liquid suspensions when properly formulated. We provide stability protocol guidance for specific applications.