Bulk L-Ergothioneine Powder Manufacturer in China
wholesale pricing, 99% pure, ideal for capsules, tablets, powders, and beverages. Full technical documentation, OEM support, 500 tons export, free sample.
- Annual export capacity up to 500 tons
- Third-party tested with full COA, MSDS, TDS
- OEM & private label solutions available
- Factory-direct wholesale pricing
- ISO 9001 & ISO 22000 Certified Supplier
- Free samples for qualified customers
Home / Products / Specialty Ingredients / Wholesale L-Ergothioneine Powder
What is L-Ergothioneine?
L-Ergothioneine is a naturally occurring amino acid derivative with potent antioxidant properties, often referred to as a “longevity vitamin.” It is also known by names such as Ergothioneine or EGT and has the CAS Number 497-30-3. The molecular formula of L-Ergothioneine is C9H15N3O2S, with a molecular weight of 229.30 g/mol. In its pure form, L-Ergothioneine appears as a fine, odorless powder with a white to off-white color.
Naturally, L-Ergothioneine is found in high concentrations in certain mushrooms, such as shiitake and oyster mushrooms, and is also present in some animal tissues, including liver and kidney, due to dietary intake. Other natural sources include legumes, oat bran, and fermented foods, as it is produced by specific fungi and bacteria in the soil.
This unique compound is renowned for its ability to combat oxidative stress, reduce inflammation, and support cellular health, making it a popular ingredient in dietary supplements, anti-aging products, and nutraceuticals. Additionally, L-Ergothioneine is recognized for its potential benefits in promoting cognitive function, enhancing immunity, and protecting against various chronic conditions.
Provita Biotech proudly stands as the leading wholesale supplier of bulk L-Ergothioneine powder in China, offering high-quality, certified products to meet the demands of the global market.
L-Ergothioneine vs Glutathione
L-Ergothioneine (EGT) and Glutathione (GSH) are both powerful antioxidant supplement ingredients, but they are not the same. In general, EGT is more stable, has a dedicated transporter OCTN1/SLC22A4, accumulates in mitochondria and other high-oxidative-stress tissues, and, in some comparative data, shows about 3 to 30 times stronger free radical scavenging performance than GSH in specific models. At an equal concentration of about 0.262 mmol/L, EGT showed about 64.26% hydroxyl radical scavenging, while GSH showed about 22.2%. EGT is also effective at relatively low daily use levels such as 5-30 mg, while GSH products are commonly positioned at much higher dosages such as 250–1000 mg. However, GSH remains highly valuable for broad intracellular antioxidant defense, detoxification, liver support, and recycling vitamins C and E. For premium anti-aging, mitochondrial, longevity, and high-bioavailability formulas, EGT is often the better choice, while combining EGT and GSH can create a more complete antioxidant system.
| Item | L-Ergothioneine (EGT) | Glutathione (GSH) |
|---|---|---|
| Full Name | L-Ergothioneine | Reduced Glutathione |
| Common Names | Ergothioneine, EGT, L-(+)-Ergothioneine | Glutathione, GSH |
| CAS Number | 497-30-3 | 70-18-8 |
| Molecular Formula | C9H15N3O2S | C10H17N3O6S |
| Molecular Weight | 229.30 g/mol | 307.32 g/mol |
| Natural Sources | Mushrooms such as shiitake and porcini, cereal germ, some seafoods | Produced naturally in the body; also found in some foods in low levels |
| Production Method | Mainly fermentation for commercial bulk supply | Mainly synthetic or fermentation-related industrial processes, depending on grade |
| Specification | NLT 99.0% / commonly 99% HPLC; batch result 99.9% assay, 100.0% purity | Common market specs usually 98%–99% |
| Appearance | White to off-white powder | White to off-white powder |
| Purity | ≥99.0% HPLC; actual batch can reach 100.0% | Usually 98%–99% |
| Main Antioxidant Mechanism | Direct ROS scavenging, metal ion chelation, mitochondrial targeting, NRF2-related protection | Direct thiol antioxidant activity, GPx cofactor, redox cycling, regenerates vitamins C and E |
| Free Radical Scavenging Potency | In some data, about 3–30× stronger than GSH in specific models; DPPH scavenging reported 14× higher than glutathione at equivalent concentration; hydroxyl radical scavenging 64.26% at 0.262 mmol/L | Hydroxyl radical scavenging about 22.2% at 0.262 mmol/L in the cited comparison, lower than EGT in some free radical models |
| Cellular Targeting | Has a dedicated transporter OCTN1 / SLC22A4 / ETT; accumulates in mitochondria, lysosomes, brain, liver, skin, eyes, and kidneys | Broad intracellular distribution but no dedicated tissue-targeting transporter highlighted in this comparison |
| Bioavailability | High oral bioavailability due to active transport and tissue retention | Lower oral bioavailability in intact form; often improved via liposomal forms, S-acetyl glutathione, NAC precursors, or IV delivery |
| Stability | Generally, more stable and longer-lasting in the body; can persist for days to weeks according to the provided text | More easily degraded and oxidized; oral form is relatively unstable in the digestive tract |
| Effective Dosage Range | Usually 5–30 mg/day | Usually 250-1000 mg/day |
| Half-Life / Retention | Long intracellular retention, sustained antioxidant effect | Shorter-lived and needs more continuous replenishment |
| Key Health Positioning | Anti-aging, mitochondrial protection, neuroprotection, cognitive health, skin protection, longevity support | Detoxification, liver support, immune support, antioxidant recycling, skin health |
| Skincare Use | Used for photoaging defense, collagen support, and oxidative stress protection | Widely used in skin-brightening and anti-aging products |
| Main Advantage | Targeted, stable, premium antioxidant with strong mitochondrial relevance | Broad antioxidant network support and detoxification benefits |
| Main Limitation | Higher raw material cost | Lower oral stability and weaker targeted transport |
| Market Position | Fast-growing premium longevity and anti-aging ingredient | Mature, widely recognized antioxidant and detox ingredient |
| Popularity in Formulas | Growing rapidly in premium supplements, functional foods, and skincare | Still highly popular in liver, detox, immune, and beauty formulas |
| Pricing | Higher-priced premium ingredient | Usually medium to high, but generally lower than EGT on a use-level basis |
| Which Is Better? | Better for premium anti-aging, mitochondrial, cognitive, and targeted antioxidant products | Better for detox, liver support, and broad antioxidant defense products |
| Can They Be Combined? | Yes, combining EGT and GSH can provide targeted plus broad-spectrum antioxidant protection | Yes, works well with EGT in synergistic antioxidant formulas |
Certificate of Analysis of L-Ergothioneine Powder
| Property | Details |
|---|---|
| CAS Number | 497-30-3 |
| Other Names | Ergothioneine, EGT |
| Molecular Formula | C9H15N3O2S |
| Molecular Weight | 229.30 g/mol |
| Solubility | Soluble in water and alcohol |
| Main Benefits | Antioxidant properties, reduces oxidative stress, promotes cognitive function, enhances immunity, supports anti-aging, and protects cellular health |
| Bulk Package | 25 kg/drum |
| OEM Services | Private labels, capsules, tablets |
Application
Antioxidant Protection
L-Ergothioneine neutralizes free radicals and reduces oxidative stress, protecting cells and tissues from damage. It supports anti-aging and overall cellular health, making it ideal for wellness and longevity products.
Brain Health
L-Ergothioneine crosses the blood-brain barrier to protect neurons, boosting cognitive function, memory, and mental clarity. It offers potential benefits for neurodegenerative conditions like Alzheimer’s and Parkinson’s.
Immune Suport
L-Ergothioneine reduces inflammation and strengthens immune cells, boosting resilience against illnesses and infections. It supports overall health, especially in high-stress or aging populations.
L-Ergothioneine powder Manufacturing Process
L-(+)-Ergothioneine powder is a naturally fermented compound produced through a meticulous process to achieve a purity of up to 99%. This advanced manufacturing process uses fermentation technology and multiple purification steps to ensure high-quality output suitable for dietary supplements, pharmaceuticals, and cosmetics. Below is a detailed explanation of the process.
1. Seed Culture and Fermentation
The process begins with cultivating microbial seed cultures under controlled conditions. These microorganisms are specifically selected for their ability to biosynthesize L-(+)-Ergothioneine. The fermentation process is carried out in optimized environments, enabling the microorganisms to produce the compound efficiently and sustainably.
2. Initial Purification – Membrane Filtration and Cell Disruption
After fermentation, the broth containing L-(+)-Ergothioneine is subjected to membrane filtration, which separates the microbial cells from the liquid containing the desired compound. To extract any intracellular L-(+)-Ergothioneine, the microbial cells are disrupted, releasing the compound into the solution. A second round of membrane filtration is performed to remove any remaining cell debris and further purify the liquid.
3. Ultrafiltration and Ion Exchange
The purified solution undergoes ultrafiltration, concentrating the L-(+)-Ergothioneine while removing smaller impurities. Following this, the solution is passed through two stages of ion exchange purification, a critical step to ensure the compound’s purity reaches up to 99%. This step eliminates any residual impurities, achieving pharmaceutical-grade quality.
4. Vacuum Concentration and Crystallization
Once purified, the solution is subjected to vacuum concentration to reduce its volume and prepare it for crystallization. The concentrated solution is then crystallized, forming solid L-(+)-Ergothioneine. This step ensures the compound is stable, high-purity, and suitable for use in various applications.
5. Final Processing – Centrifugation, Drying, and Aseptic Packaging
The crystallized material is separated from the liquid using centrifugation to ensure uniform particle size and consistency. It is then dried to form a fine powder, achieving the desired moisture content for stability and ease of use. Finally, the dried powder is packed in sterile conditions using aseptic processing, typically in 25 kg drums, to maintain its quality during transport and storage.
L-Ergothioneine Benefits
Powerful Antioxidant Protection
L-Ergothioneine is a potent antioxidant that neutralizes free radicals and reduces oxidative stress. By protecting cells and tissues from damage, it slows the aging process, enhances cellular health, and helps prevent chronic diseases.Supports Cognitive Health
Known for crossing the blood-brain barrier, L-Ergothioneine protects neurons from oxidative damage, promoting brain health. It enhances cognitive function, memory, and mental clarity while potentially reducing the risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.Boosts Immune Function
L-Ergothioneine strengthens the immune system by reducing inflammation and protecting immune cells from oxidative stress. This makes it an effective compound for improving resilience against infections and illnesses.Reduces Inflammation
L-Ergothioneine helps mitigate inflammation at the cellular level, benefiting conditions related to chronic inflammation, such as arthritis, cardiovascular issues, and metabolic disorders.Promotes Skin Health
Its ability to protect skin cells from oxidative damage makes L-Ergothioneine a valuable ingredient in skincare. It reduces signs of aging, improves skin hydration, and shields the skin from environmental stressors like UV radiation.Protects Mitochondrial Function
L-Ergothioneine supports mitochondrial health by reducing oxidative stress, ensuring efficient energy production, and enhancing overall cellular vitality.Enhances Cardiovascular Health
By reducing oxidative damage and inflammation, L-Ergothioneine contributes to better heart health. It may help protect against atherosclerosis and other cardiovascular diseases.
These diverse benefits make L-Ergothioneine a highly sought-after ingredient in dietary supplements, pharmaceuticals, and skincare products aimed at promoting health, longevity, and vitality.
Where to buy L-Ergothioneine bulk powder?
ProVita Biotech is a leading supplier of L-Ergothioneine powder for sale, offering 99% pure L-Ergothioneine for use in dietary supplements, pharmaceuticals, and cosmetics. Manufactured in our advanced factory and manufacturing facility, we produce up to 10 tons per month, ensuring a reliable supply for B2B bulk buyers. Each batch is tested using HPLC and comes with a third-party lab quality certificate to guarantee premium quality.
To meet global demand, we maintain inventory in warehouses located in the United States, France, Australia, and New Zealand, with local distributors at each branch for fast and efficient service. Our L-Ergothioneine powder is naturally sourced and sustainably produced, making it an ideal choice for health and wellness applications.
We also provide free samples for evaluation, helping you confirm the quality of our product before purchase. Contact us today for a wholesale quotation and secure high-quality L-Ergothioneine bulk powder at competitive prices. Let ProVita Biotech be your trusted partner for all your L-Ergothioneine needs.
FAQs
L-Ergothioneine is the biologically active natural isomer used in supplements and pharmaceuticals, while “Ergothioneine” is often used as a general term in the market. For commercial and regulatory purposes, L-Ergothioneine (CAS 497-30-3) is the standard and preferred form for formulations.
Fermentation-derived L-Ergothioneine offers:
- Higher purity consistency (≥99% HPLC)
- Better scalability for bulk supply
- More sustainable and market-preferred production
Synthetic methods may vary in purity and are less commonly used in high-end supplement applications.
Fast-growing demand comes from:
- Anti-aging & longevity supplements
- Cognitive health products
- Premium skincare brands
- Functional food & beverage manufacturers
Yes, we support customization based on:
- Target dosage levels
- Market regulations (USA, EU, Asia)
- Label claims (anti-aging, cognitive, immune)
- Delivery formats (capsules, powders, beverages)
ProVita Biotech holds internationally recognized certifications, including ISO 9001, ISO 22000, GMP, HACCP, Kosher, Halal, Organic Certification, Non-GMO Certification, Third-Party Lab Testing Certification, EU REACH Compliance, FDA Registration, and BRCGS Certification. These certifications ensure the highest standards for quality, safety, and global compliance.
Yes, we offer free samples. You can either arrange for collection using your own courier account or have us handle the shipping, with the freight charges covered by you. Moreover, the shipping cost will be reimbursed as a deduction from your bulk order payment.
We do not enforce a strict Minimum Order Quantity (MOQ), offering flexibility to meet your needs. However, please note that smaller quantities may come with a higher unit price. Our standard packaging is 25kg per drum, making 25kg an ideal starting point for bulk purchases. We also accommodate smaller orders, such as 10kg or custom quantities, though the unit cost may slightly increase. Contact us today to discuss your specific requirements and receive a competitive quotation.
Yes, we have an extensive global network with branches, warehouses, and local ingredient distributors strategically located in major regions, including California (USA), Paris (Europe), Singapore (Asia), Shanghai (China), and Chestiville (Australia). This ensures fast and efficient delivery of our high-quality ingredients to customers worldwide.
Yes, ProVita Biotech provides full OEM/ODM services, including:
- Capsules
- Tablets
- Softgels
- Powder blends
- Customized formulations
We provide complete documentation including:
- COA (Certificate of Analysis)
- MSDS (Safety Data Sheet)
- TDS (Technical Data Sheet)
- GMP, ISO certifications
- Kosher & Halal (if required)