L-Glutamine Powder
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What is L-Glutamine?
L-Glutamine (CAS No. 56-85-9), also known as (S)-2,5-Diamino-5-oxopentanoic acid or Levoglutamide, is the most abundant free amino acid in the human body with a molecular formula of C₅H₁₀N₂O₃ and a molecular weight of 146.15 g/mol. This conditionally essential amino acid appears as a white crystalline powder with high bioavailability of approximately 65-80% when taken orally. It can be found naturally in various botanical sources including spinach, parsley, cabbage, and beans, though commercial L-Glutamine is typically produced through fermentation processes. Standard specifications for pharmaceutical-grade L-Glutamine include ≥99% purity, with moisture content <0.5%, and heavy metals <10ppm. Provita Biotech stands as the leading bulk L-Glutamine powder supplier in China, providing high-quality product that meets strict international standards for use in nutritional supplements, sports nutrition formulations, and pharmaceutical applications.
Glutamine vs Glutamate
When comparing Glutamine and Glutamate, it’s important to note that neither is inherently “better” as they serve distinct physiological roles. Glutamine is primarily valued as a conditionally essential amino acid used for muscle recovery, immune function, and gut health, while Glutamate functions as the primary excitatory neurotransmitter in the brain and is critical for cognitive function. Their applications differ significantly – Glutamine is widely used as a dietary supplement for sports nutrition and clinical applications, whereas Glutamate is primarily important as a flavor enhancer (as MSG) and for neurological functions. The choice between them depends entirely on the specific health goal or application rather than one being superior to the other.
| Characteristic | L-Glutamine | L-Glutamate |
|---|---|---|
| CAS Number | 56-85-9 | 56-86-0 |
| Other Names | (S)-2,5-Diamino-5-oxopentanoic acid, Levoglutamide | Glutamic acid, 2-Aminoglutaric acid, MSG (as sodium salt) |
| Molecular Formula | C₅H₁₀N₂O₃ | C₅H₉NO₄ |
| Molecular Weight | 146.15 g/mol | 147.13 g/mol |
| Appearance | White crystalline powder | White crystalline powder or crystals |
| Purity (commercial) | ≥99% | ≥99% |
| Bioavailability | Moderate to high (65-80%) | Lower than glutamine when taken orally |
| Potency | Moderate as supplement | High as neurotransmitter |
| Half-life | ~1 hour in plasma | ~30 minutes in neural tissue |
| Stability | Stable in dry form; less stable in solution | More stable than glutamine in solution |
| Popularity (as supplement) | Very high | Low (except as MSG in food) |
| Pricing | Moderate ($20-50/kg bulk) | Lower ($15-40/kg bulk) |
| Main Benefits | Muscle recovery, immune function, gut health, wound healing | Neurotransmitter function, flavor enhancement, brain metabolism |
| Primary Functions | Protein synthesis, nitrogen transport, cell volumizing | Excitatory neurotransmitter, umami taste, brain metabolism |
| Safety Profile | Generally recognized as safe (GRAS) | GRAS, but controversial as MSG for some individuals |
| Supplement Use | Widely used | Rarely used as direct supplement |
| Clinical Applications | Critical illness, burns, surgical recovery | Limited direct applications (primarily neurological research) |
| Conversion | Can convert to glutamate | Can be synthesized from glutamine |
L-Glutamine COA
ProVita Biotech’s premium L-Glutamine Powder (CAS: 56-85-9, Batch: G230501) demonstrates exceptional quality with a certified assay of 99.30% purity, comfortably within the 98.5-101.5% specification range required by AJI92/USP standards. The rigorous testing confirms safety with all heavy metals well below threshold limits, including Lead (Pb) <10 ppm, Arsenic (As) <1 ppm, and Iron (Fe) <10 ppm. Residual testing shows minimal processing remnants with Loss on Drying at just 0.13% (≤0.2% standard) and Residue on Ignition at 0.03% (≤0.1% standard). Microbiological analysis confirms product safety with Total Plate Count <1000 cfu/g, Yeast & Mold <100 cfu/g, and negative results for pathogenic bacteria. This pharmaceutical-grade L-Glutamine, manufactured on 2023-05-01 with a one-year shelf life, exemplifies ProVita Biotech’s commitment to delivering premium amino acid ingredients that meet the strictest global quality standards.
Application
Sports Nutrition
L-Glutamine is a key amino acid that supports muscle growth and recovery. By replenishing depleted glutamine levels post-workout, it helps reduce muscle soreness and promotes protein synthesis, making it a popular choice among athletes and fitness enthusiasts.
Digestive Health
This amino acid plays a vital role in maintaining a healthy gut lining. L-Glutamine supports intestinal cell regeneration, aids nutrient absorption, and helps strengthen the gut barrier, contributing to overall digestive wellness.
Immune Support
As an abundant amino acid in the body, L-Glutamine fuels immune cells and helps maintain their optimal function. Supplementing with glutamine may support immune resilience, particularly during periods of stress or intense physical activity.
L-Glutamine Powder Manufacturing Process
Raw Material & Fermentation
- Premium glucose preparation serves as optimal carbon source
- Proprietary bacterial strains used for maximum L-Glutamine yield
- Precision-controlled fermentation parameters (pH, temperature, aeration)
- Computer-monitored bioreactors ensure consistent production
Primary Separation
- Advanced membrane filtration removes cellular debris
- Multi-stage concentration technique concentrates L-Glutamine
- Crude filtration eliminates larger particulates
- Automated systems maintain process integrity
Purification Process
- Activated carbon decolorization removes pigments and organic impurities
- Specialized ion exchange chromatography eliminates ionic contaminants
- Nanofiltration membrane technology (0.01μm) removes residual molecules
- Three-stage purification ensures pharmaceutical-grade quality
Crystallization
- Single-effect evaporation concentrates solution without degradation
- Fine crystal cultivation with controlled temperature gradients
- Proprietary seeding technique produces uniform crystal formation
- Cooling separation isolates high-purity crystals from mother liquor
Finishing Process
- State-of-the-art vacuum drying preserves amino acid integrity
- Precision milling achieves 80-120 mesh particle distribution
- Metal detection and multi-stage filtration (0.3μm PES, 0.45μm SUS)
- Critical Control Points monitor key quality parameters throughout production
Quality Assurance
- Each batch achieves 99% minimum purity
- Comprehensive testing against USP/EP/JP pharmacopeia standards
- HPLC assay, heavy metals screening, microbial testing
- Third-party laboratory verification
- Nitrogen-flush packaging ensures 24-month stability
- Full traceability from raw materials to finished product
Certifications
- ISO 9001, GMP, HACCP certified facility
- FSSAI, Halal and Kosher certified product
- FDA registered manufacturing process
- Environmentally sustainable production methods
L-Glutamine Benefits
- Muscle Recovery: Helps reduce muscle soreness and supports faster post-workout recovery.
- Protein Synthesis: Aids in building and maintaining lean muscle mass for enhanced athletic performance.
- Gut Health: Supports intestinal integrity by nourishing gut cells and promoting a healthy digestive system.
- Immune Function: Fuels immune cells, helping maintain resilience and overall health.
- Energy Production: Assists in cellular energy metabolism, contributing to sustained stamina and endurance.
Where to buy L-Glutamine bulk powder?
At ProVita Biotech, we understand the importance of sourcing high-quality L-Glutamine bulk powder for your formulations and products. Our pharmaceutical-grade L-Glutamine powder is manufactured in FDA-registered facilities and undergoes rigorous quality testing to ensure purity, potency, and consistency.
Purchasing Options
- Direct Wholesale: Order L-Glutamine bulk powder directly from our secure online portal
- Custom Quantities: Available in quantities from 1kg to metric tons
- Certificate of Analysis: Each L-Glutamine batch comes with comprehensive documentation
- Competitive Pricing: Volume discounts available for regular orders
Our L-Glutamine bulk powder meets USP/EP standards and is ideal for dietary supplements, sports nutrition products, and pharmaceutical applications. With guaranteed 99%+ purity and fast shipping options, ProVita Biotech remains the trusted source for premium amino acid ingredients.
Contact our sales team for current L-Glutamine bulk powder pricing or to request samples for evaluation.
FAQs
While both are important in cellular health, L-Glutamine is the most abundant amino acid in the body supporting muscle recovery and intestinal health. Glutathione functions primarily as an antioxidant. For sports nutrition products, L-Glutamine offers superior benefits for muscle recovery and immune support, while glutathione is better positioned for antioxidant formulations.
L-Glutamine works synergistically with BCAAs (Leucine, Isoleucine, and Valine). While BCAAs directly stimulate muscle protein synthesis, L-Glutamine supports recovery, reduces muscle soreness, and enhances immune function. Many of our partners include both in their formulations for comprehensive recovery benefits.
L-Glutamine and Creatine serve different functions in performance nutrition. Creatine primarily increases ATP production for explosive strength and power, while L-Glutamine supports recovery, immune function, and gut health. They can be effectively combined in product formulations for complementary benefits.
Though structurally similar, Glutamic Acid functions primarily as an excitatory neurotransmitter, while L-Glutamine supports protein synthesis, immune function, and gut health. For most sports nutrition and health supplement applications, L-Glutamine provides broader benefits.
Our L-Glutamine is produced through bacterial fermentation using non-GMO ingredients, followed by purification, crystallization, and quality testing. This process ensures consistent 99.5%+ purity levels and minimal heavy metal content.
ProVita Biotech offers L-Glutamine with purity levels of 99.0%, 99.5%, and 99.9+% (pharmaceutical grade). All products are tested via HPLC and meet or exceed USP/EP specifications.
Our L-Glutamine is manufactured in FDA-registered, cGMP-certified facilities. We provide full documentation including Certificate of Analysis, Certificate of Origin, MSDS, and Allergen Statements. Additionally, our product is Kosher and Halal certified with non-GMO documentation available.
Our standard MOQ is 25kg for regular L-Glutamine and 10kg for pharmaceutical-grade. For new clients, we offer sample quantities of 1kg for quality evaluation.
We offer tiered pricing at 25kg, 100kg, 500kg, and 1 metric ton levels. Volume discounts begin at 100kg orders, with additional discounts for long-term supply agreements.
Yes, ProVita Biotech offers comprehensive OEM services including custom packaging, blending with other ingredients, and various particle sizes to meet your specific formulation requirements.
We offer customization options including micronization for improved dissolution, instantized versions for better mixability, and various mesh sizes to suit different production requirements.