Bulk Methylene Blue Powder 99%
USP Pharmaceutical grade, 99% Pure Ingredient of Methylthioninium Chloride for Brain Health, Anti-aging Wholesale price, Kosher, Halal, FDA-approved
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What is Methylene Blue?
Methylene Blue (Methylthioninium Chloride) is a synthetic thiazine dye with no botanical sources, traditionally used as a histological and microbiological stain, a redox indicator in analytical chemistry, and a therapeutic agent for malaria, methemoglobinemia and cyanide poisoning. Its modern popularity stems from breakthrough research showing that it enhances mitochondrial electron transport, delivers neuroprotective and cognitive-boosting effects, and supports anti-aging and longevity by improving cellular energy production and reducing oxidative stress. It is supplied as anhydrous Methylene Blue (CAS 61-73-4), Methylene Blue hydrate (CAS 122965-43-9) and Methylene Blue trihydrate (CAS 7220-79-3), also known as CI 52015, Swiss Blue or Urolene Blue. The core molecular formula is C₁₆H₁₈ClN₃S (MW 319.85 g/mol anhydrous; 373.90 g/mol trihydrate), and it meets ≥99 % HPLC purity. This dark green crystalline powder has excellent water solubility and favorable oral or parenteral bioavailability, is packaged in 25 kg drums, and is backed by Provita Biotech, the leading bulk Methylene Blue powder supplier in China, offering both liquid and powdered raw ingredients as well as OEM services for capsules, tablets and more.
Methylene Blue trihydrate vs Methylene Blue (Anhydrous)
For most bulk supply and routine applications, Methylene Blue trihydrate is the most popular form for supplement fomrulations and offers the best balance of cost-effectiveness, stability and ease of handling. Anhydrous Methylene Blue can be chosen when maximal active-ingredient potency per gram and minimal water content are critical, but it carries a higher price and requires more stringent moisture control.
| Property | Methylene Blue Trihydrate | Methylene Blue Anhydrous |
|---|---|---|
| CAS Number | 7220-79-3 | 61-73-4 |
| Other Names | CI 52015; Swiss Blue; Urolene Blue | CI 52015; Swiss Blue; Urolene Blue |
| Molecular Formula | C₁₆H₁₈ClN₃S·3H₂O | C₁₆H₁₈ClN₃S |
| Molecular Weight | 373.90 g/mol | 319.85 g/mol |
| Appearance | Dark green crystalline powder | Dark green crystalline powder |
| Food Sources | None (fully synthetic) | None (fully synthetic) |
| Specifications | ≥99% by HPLC | ≥99% by HPLC |
| Purity (active % by weight) | ~85.6% active (rest water) | ~100% active |
| Solubility | ≈430 g/L in water at 20 °C | ≈430 g/L in water at 20 °C |
| Hygroscopicity | Minimal | Moderate—requires moisture-tight storage |
| Bioavailability | High (approx. 60–80% oral; similar parenteral) | Very high (75–90% oral when adjusted for active content) |
| Potency | Effective, but dosing must account for water content | Higher per-gram potency |
| Typical Dosage | 0.5–4 mg/kg (based on active MB content) | 0.5–4 mg/kg (easier to calculate precise dose) |
| Elimination Half-Life | ~5–6 hours | ~5–6 hours |
| Stability | Very stable at room temperature; long shelf life | Stable if kept dry; may clump if exposed to humidity |
| Popularity | More widely used in labs, clinical and nutraceutical products | Favored where strict water-free formulations are required |
| Pricing (approx.) | ~$200–$350 per kg | ~$300–$450 per kg |
| Main Benefits | Standardized bulk supply; cost-effective; easy handling | Maximal potency; precise dosing; ideal for custom formulation |
| Packaging | 25 kg drum | 25 kg drum |
| Typical Applications | Histology stains, redox indicator, methemoglobinemia treatment, longevity supplements | High-precision pharmaceuticals, OEM capsules/tablets requiring low moisture |
This comparison shows that Methylene Blue trihydrate is generally the better choice for broad applications and bulk supply, while the anhydrous form is best when maximum active-ingredient concentration and strict moisture control are paramount.
Methylene Blue Forms: Why powder is better than liquid or drops?
- Superior Stability
Bulk Methylene Blue powder resists oxidation and degradation better than liquid or drop formulations, ensuring longer shelf life and consistent potency. - Potency & Purity
Powder is 99% pure and highly efficient, while liquid Methylene Blue is only 0.5–1% active dye. - Precise Dosing Every Time
Powder in capsule can achieve a perfect dose with one or two capsules per serverving, no guesswork required. - No Blue Mouth & Neutral Taste
Powder dissolves fully in water, avoiding mouth staining and the harsh flavor of liquid dyes. - Safety & Clean Label
Super pure, free from formaldehyde, preservatives and solvents; ideal for clean-label capsules, tablets, drops or OEM blends. - Water Solubility & Ease of Use
Easily soluble; perfect for DIY 1% solutions or to formulate Methylene Blue pills, drops, capsules and tablets. - Cost-Effective Shipping & Storage
Lightweight powder reduces freight costs and avoids hazardous-goods surcharges associated with liquids. - Flexible Formulation
OEM-friendly powder can be blended into any dosage form without extra solvent removal steps. - Guaranteed Quality
Meets GMP, Kosher and Halal standards; all batches undergo third-party testing with full certificates.
ProVita Biotech’s 99% pure Methylene Blue powder delivers unmatched potency, precise dosing, neutral taste and clean-label safety, making it the superior choice over low-concentration liquid or drop formulations.
Methylene Blue Certificate of Analysis(COA)
ProVita Biotech’s Certificate of Analysis for Methylthioninium Chloride Trihydrate (Methylene Blue Powder 99%) verifies an HPLC assay purity of 99.47% (≥98.5% on anhydrous basis), ultra-low heavy metals (Pb <0.05 ppm, As 0.0151 ppm, Cd 0.532 ppm and Hg 0.0159 ppm) and strict residual solvent control (Loss on Drying 14.31% ≤18.0%, Residue on Ignition 0.28% ≤1.2%). Supplied in moisture-tight 25 kg drums, the dark green crystalline powder (C₁₆H₁₈ClN₃S·3H₂O, CAS 7220-79-3) meets USP, EP and independent third-party international standards. Chemical manufacturing factories prefer the official name Methylthioninium Chloride and value this trihydrate form with three water molecules for its stability and batch-to-batch consistency. ProVita Biotech is dedicated to providing the highest quality and safety for supplement manufacturers and distributors worldwide.
Application
Cognitive Support
Methylene Blue supplements are widely used to enhance cognitive function by supporting mitochondrial ATP production in neurons and reducing oxidative stress in the brain. Studies show improved memory retention, faster mental processing, and protection against age-related neurodegeneration, making it a top choice for nootropic stacks and brain health formulas.
Mitochondrial Energy
By acting as an alternative electron carrier in the mitochondrial respiratory chain, Methylene Blue boosts cellular energy output and overall endurance. This energy-enhancing effect helps reduce mental fatigue, supports healthy muscle function, and promotes optimal performance for athletes and busy professionals alike.
Anti-Aging Support
Methylene Blue’s potent antioxidant properties help neutralize free radicals and protect cellular structures from oxidative damage. Regular supplementation has been linked to improved skin elasticity, slowed cellular aging, and enhanced longevity pathways, positioning it as a premium ingredient in anti-aging and longevity nutraceuticals.
Methylthioninium Chloride Manufacturing Process
ProVita Biotech’s Methylthioninium Chloride Trihydrate (Methylene Blue Trihydrate) powder is manufactured through a multi-step, fully controlled process to deliver a ≥99 % pure ingredient that meets USP, EP and ISO requirements and passes independent third-party testing. First, high-grade N,N-dimethyl-p-phenylenediamine sulfate and sodium thiosulfate are reacted under acidic conditions with a mild oxidant at 40–60 °C to form crude Methylene Blue. The reaction slurry is filtered to remove inorganic salts, then the filtrate is decolorized over activated carbon and further purified by alumina adsorption. Next, the clear solution is carefully recrystallized at 5–10 °C to yield trihydrate crystals (C₁₆H₁₈ClN₃S·3H₂O), which are washed with chilled water to eliminate residual ions. Crystals are vacuum-dried below 60 °C to retain exactly three water molecules and then milled to a uniform 20–40 mesh powder. Final QC includes HPLC assay for 99 % purity, ICP-MS screening for heavy metals below ppm limits, loss-on-drying and residual solvent analysis. Batches are validated by an external laboratory and packaged in moisture-proof 25 kg drums. Throughout every stage, ProVita Biotech applies stringent process controls and GMP practices to ensure maximum stability, batch-to-batch consistency and safety for supplement manufacturers and distributors.
Benefits of Methylene Blue Supplements
- Cognitive Enhancement: Methylene Blue supplement boosts brain health by supporting mitochondrial ATP production and improving memory recall.
- Neuroprotective Action: Protects neurons from oxidative stress and age-related degeneration to maintain long-term brain function.
- Cellular Energy Boost: Acts as an alternative electron carrier in mitochondria to increase physical endurance and reduce mental fatigue.
- Antioxidant Defense: Neutralizes free radicals, protecting cells from damage and supporting overall vitality.
- Anti-Aging Support: Promotes longevity pathways and slows cellular aging by enhancing mitochondrial efficiency.
- Metabolic Health: Optimizes energy metabolism and supports healthy mitochondrial function for balanced bioenergetics.
- Mood & Stress Resilience: Supports neurotransmitter balance and reduces oxidative stress to help regulate mood and stress response.
Where to buy bulk Methylene Blue powder?
ProVita Biotech Co., Ltd. is your China factory and leading supplier of high quality bulk Methylene Blue powder. We offer competitive Methylene Blue pricing for wholesale orders and OEM services for Methylene Blue Pills, Methylene Blue Drops, capsules, and tablets. All raw materials undergo third-party testing and meet GMP, Kosher, and Halal standards with full certificates available. Contact us today for free sample requests and volume discounts on bulk Methylene Blue powder. Trust ProVita Biotech for reliable supply, fast shipping, and guaranteed purity.
FAQs
Breakthrough research highlights its role in enhancing mitochondrial electron transport, providing neuroprotection, boosting cognitive function and supporting anti-aging pathways, driving renewed interest in both clinical and supplement markets.
Powder is 99 % pure, offers precise dosing, neutral taste and no mouth staining. Liquid forms are only 0.5–1 % active, often contain preservatives and can taste harsh.
Yes. Methylene Blue is the common name for Methylthioninium Chloride, a synthetic thiazine dye. In chemical manufacturing and on Certificates of Analysis you will often see the official name Methylthioninium Chloride (CAS 7220-79-3 for trihydrate).
At recommended low doses (0.5–4 mg/kg) it is generally well tolerated. Side effects can include mild gastrointestinal upset or blue-tinged urine. People with G6PD deficiency or those on MAO inhibitors should consult a healthcare professional before use.
It can be both. High-purity Methylene Blue powder is sold as a nutraceutical supplement for cognitive and mitochondrial support. Certain pharmaceutical-grade formulations are approved drugs for methemoglobinemia, malaria and cyanide poisoning.
Yes, specific injectable and oral formulations of Methylthioninium Chloride are FDA-approved drugs for treating methemoglobinemia. Over-the-counter supplement forms are not FDA-approved as drugs but are regulated as dietary ingredients.
It acts as an alternative electron carrier in neuronal mitochondria, improving ATP production, reducing oxidative stress, and supporting memory, focus and neuroplasticity.
• Powder (99 % pure trihydrate) for precise dosing and OEM capsules/tablets
• Liquid or drops (0.5–1 % solution) for easy administration
• Pre-measured capsules and tablets for convenience
Popular Ingredients Often Stacked with Methylene Blue
NAD⁺ Precursors (NMN, Nicotinamide Riboside)
Support mitochondrial function upstream of Methylene Blue’s electron-carrier activity.Coenzyme Q10 & PQQ
Synergize to enhance electron transport chain efficiency and protect against oxidative stress.Acetyl-L-Carnitine (ALCAR) & Alpha-Lipoic Acid (ALA)
Boost mitochondrial energy metabolism and provide complementary antioxidant support.CDP-Choline & Uridine Monophosphate
Enhance phospholipid synthesis for improved neuroplasticity and cognitive function.Creatine & Taurine
Serve as cellular energy buffers and osmolytes to support sustained performance and cell hydration.B-Complex Vitamins (B1, B6, B12)
Act as essential cofactors in enzymatic reactions throughout mitochondrial pathways.Omega-3 Fatty Acids
Provide anti-inflammatory and neuroprotective benefits that complement Methylene Blue’s effects.Resveratrol & Pterostilbene
Activate longevity pathways (SIRT1/AMPK) to magnify anti-aging outcomes.Caffeine + L-Theanine
Combine for focused alertness and calm mental energy alongside Methylene Blue’s nootropic action.Adaptogens (Rhodiola Rosea, Ashwagandha)
Improve stress resilience and support overall cognitive endurance.