S-Equol Powder
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What is S-Equol?
S-Equol is a naturally occurring metabolite of the soy isoflavone daidzein. It has the CAS number 531-95-3 and is also known as (3S)-3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol. S-Equol has the molecular formula C15H14O3 and a molecular weight of 242.27 g/mol. It is available as a 99% HPLC pure white crystalline powder. Wholesale S-Equol has good bioavailability and is typically supplied in 25kg drums. Provita Biotech is the leading bulk S-Equol powder supplier in China, and also offer powdered S-Equol raw ingredients, as well as OEM capsules, tablets, and other nutritional ingredients.
S-Equol vs Soy Isoflavones
S-Equol is considered superior to soy isoflavones in several ways. As a metabolite of the soy isoflavone daidzein, S-Equol is more bioavailable and potent than its precursor compounds. It also has a higher affinity for binding to estrogen receptors, making it more effective at eliciting estrogenic effects in the body.
The table below compares the key properties of S-Equol and soy isoflavones:
| Property | S-Equol | Soy Isoflavones |
|---|---|---|
| CAS Number | 531-95-3 | N/A |
| Other Names | (3S)-3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol | Daidzein, Genistein, Glycitein |
| Molecular Formula | C15H14O3 | Varies per isoflavone |
| Molecular Weight | 242.27 g/mol | Varies per isoflavone |
| Appearance | White crystalline powder | Powders or extracts |
| Food Sources | Soy products, fermented soy foods | Soybeans, soy foods |
| Specifications | 99% HPLC | Varies |
| Purity | ≥99% | Typically 40-80% |
| Bioavailability | Higher | Lower |
| Potency | Higher | Lower |
| Dosage | Typically 10-40 mg/day | Typically 50-100 mg/day |
| Half-Life | 8-9 hours | 6-8 hours |
| Stability | Stable | Varies |
| Popularity | Growing | Well-established |
| Pricing | Higher | Lower |
| Main Benefits | Binds to estrogen receptors, supports heart, bone, and cognitive health | Some estrogenic effects, supports overall health |
In summary, S-Equol is superior to soy isoflavones due to its higher bioavailability, potency, and affinity for estrogen receptors. While soy isoflavones provide some health benefits, S-Equol is a more targeted and effective option for individuals looking to harness the power of these phytoestrogens.
S-Equol Powder specification
ProVita Biotech’s S-Equol powder (99% purity) meets rigorous international standards, ensuring the highest quality for supplement manufacturers and distributors. The assay demonstrates a purity of ≥99%, verified using HPLC. The product is tested for heavy metals, with arsenic, lead, mercury, and cadmium levels all meeting the strict limit of ≤1.0 ppm, while total heavy metals do not exceed 10 ppm, as per USP <233>. Additionally, residual solvents, including ethanol, are below 200 ppm (USP <467>). ProVita Biotech guarantees that each batch is packaged securely and adheres to the specifications outlined by recognized industry standards, ensuring safety, consistency, and compliance with third-party quality certifications. At ProVita Biotech, we prioritize product quality and safety to support our clients in providing top-tier supplements.
Application
Menopausal Symptom Relief
S-Equol is highly effective in alleviating menopausal symptoms, such as hot flashes and night sweats. As a natural phytoestrogen, S-Equol mimics estrogen in the body, offering relief from hormonal fluctuations during menopause, making it a popular choice for menopausal symptom relief supplements.
Bone Health
S-Equol supports bone health by enhancing bone density and reducing the risk of osteoporosis. It helps stimulate estrogen receptor activity in bones, promoting better bone strength and integrity, making it an essential ingredient in bone health supplements.
Hormonal Balance
S-Equol plays a crucial role in maintaining hormonal balance, especially in women. By acting as a natural estrogenic compound, it helps regulate estrogen levels, supporting overall hormonal equilibrium and improving well-being, particularly during perimenopause and menopause.
S-Equol Manufacturing Process
ProVita Biotech’s S-Equol powder (99% purity) is produced through a sophisticated and highly controlled manufacturing process that ensures the highest quality and consistency. The process begins with Reverse Osmosis Water and Filtered Air, which are used to prepare the culture medium for fermentation. The fermentation process is initiated with the introduction of specific Microbiota and Daizein to produce the desired compound. Following fermentation, the mixture undergoes Centrifugation to separate solid materials.
Next, Cell Wall Breaking is performed to release the beneficial compounds, followed by Membrane Filtration and Ion Exchange to purify the solution further. The solution is then subjected to Heating Concentration, where it is concentrated under controlled heat to ensure the quality of the extract.
Ethanol is added to the concentrated solution, facilitating the Crystallization of the S-Equol. The crystallized product is then processed through Filtration to remove any residual impurities, followed by Drying to eliminate moisture and ensure product stability. Finally, the S-Equol is carefully packaged to preserve its purity and quality.
ProVita Biotech’s manufacturing process adheres to international standards and undergoes rigorous third-party quality testing, ensuring that the final S-Equol powder (99% pure) is of the highest quality, suitable for use in dietary supplements and other applications.
S-Equol Benefits
- Supports Healthy Estrogen Levels – S-Equol has been shown to bind to estrogen receptors and help maintain healthy estrogen levels in the body.
- Promotes Bone Health – S-Equol may help support bone density and strength by influencing bone metabolism and mineralization.
- Helps Manage Menopause Symptoms – Studies suggest S-Equol can help alleviate common menopausal symptoms like hot flashes, night sweats, and vaginal dryness.
- Supports Cardiovascular Health – S-Equol’s antioxidant and anti-inflammatory properties may contribute to maintaining healthy blood pressure and cholesterol levels.
- Encourages Healthy Skin – S-Equol may have skin-nourishing benefits by improving skin elasticity and reducing the visible signs of aging.
Where to buy S-Equol bulk powder?
As the premier manufacturer of high-quality S-Equol in China, ProVita Biotech is the top choice for businesses seeking bulk S-Equol powder. Our state-of-the-art GMP-certified facility ensures the purity, potency and consistency of our S-Equol ingredients.
Customers can purchase S-Equol powder in bulk quantities, with competitive wholesale pricing and the option for OEM/private label formulations. We offer free samples to qualified buyers, and our products undergo rigorous third-party testing to verify purity and potency.
In addition to our S-Equol powder, we also provide Kosher and Halal-certified versions to accommodate diverse market requirements. ProVita Biotech is proud to be a leading China-based supplier of premium S-Equol ingredients to supplement brands and manufacturers worldwide.
Contact us today to discuss your bulk S-Equol powder needs and receive a free quote. Experience the quality and reliability that has made ProVita Biotech the trusted source for high-purity, GMP-certified S-Equol.
FAQs
S-Equol is a naturally-occurring metabolite produced when gut bacteria act on the soy isoflavone daidzein. Our premium-grade S-Equol is extracted and purified from non-GMO soy in our GMP-certified facility.
Equol exists as two enantiomers: S-Equol and R-Equol.
S-Equol is the biologically active form produced by intestinal bacteria and has selective estrogen receptor β binding.
R-Equol is not naturally occurring and exhibits weaker estrogenic effects.
While soy isoflavones like daidzein and genistein offer health benefits, research indicates S-Equol may be more effective at managing menopausal symptoms and supporting bone, heart, and skin health. S-Equol has a higher bioavailability and binds more strongly to estrogen receptors.
S-Equol exhibits stronger and more targeted biological activity, especially in hormone-related health conditions such as menopausal symptoms, skin aging, and prostate health. Only 30–50% of the population can naturally convert daidzein to S-equol, making direct supplementation more effective.
(S)-Equol selectively binds to estrogen receptor beta (ER-β) without interfering with tissues regulated by estrogen receptor alpha (ER-α).
| Feature | S-Equol | Daidzein |
|---|---|---|
| CAS Number | 94105-90-5 | 486-66-8 |
| Source | Metabolite of daidzein | Natural isoflavone in soy |
| Estrogen Receptor Binding | Strong affinity to ER-β | Weak binding to both ER-α and ER-β |
| Biological Potency | Higher | Lower |
| Stability | Stable in powder form under dry, cool storage | Less stable than S-Equol in biological systems |
| Market Price | Higher (due to fermentation or synthesis complexity) | Lower |
Many healthcare providers recommend S-Equol as a safe, natural way to help alleviate common menopausal issues like hot flashes, night sweats, and vaginal dryness. Our high-purity S-Equol powder is an excellent choice for formulating specialized menopause support supplements.
Equol is primarily produced by gut bacteria when soy isoflavones like daidzein are metabolized. Only about 30-50% of the population are "equol producers" who can naturally convert daidzein to equol. Our S-Equol powder provides a standardized, high-concentration source of this valuable compound.
The conversion of the soy isoflavone daidzein to equol varies greatly between individuals based on gut microbiome composition. Studies show that anywhere from 30-50% of adults are "equol producers" capable of this metabolic conversion.
While equol itself is not a FDA-approved drug, S-Equol derived from soy is generally recognized as safe (GRAS) for use in foods and supplements in the United States. Our S-Equol powder meets all FDA regulations for dietary supplement ingredients.
There is no scientific evidence linking S-Equol supplementation to hair loss. In fact, research suggests S-Equol may have anti-aging benefits for skin and hair by supporting collagen production and reducing oxidative stress.
ProVita Biotech is the leading manufacturer of high-quality S-Equol powder in China. We offer wholesale pricing, custom OEM/private label formulations, free samples, and quick international delivery. Contact us today to discuss your bulk S-Equol requirements.