TUDCA Powder
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What is TUDCA Powder?
TUDCA (Tauroursodeoxycholic Acid, CAS 14605-22-2) is a water-soluble bile acid derivative with molecular formula C₂₆H₄₅NO₆S and molecular weight of 499.7 g/mol. Also known as tauroursodeoxycholate, TUDC, or tauro-conjugated UDCA, it’s a naturally occurring compound found in small amounts in bear bile and human bile. Provita Biotech, the leading bulk TUDCA Powder supplier in China, produces pharmaceutical-grade TUDCA at 99% purity with exceptional quality control. Our TUDCA appears as a fine white to off-white crystalline powder with high bioavailability (approximately 60-70% when administered orally), making it efficiently absorbed by the body. The compound’s hydrophilic properties enable it to be easily incorporated into various formulations for dietary supplements, pharmaceuticals, and research applications.
TUDCA vs Milk Thistle
When comparing TUDCA and Milk Thistle (specifically its active compound Silymarin), both offer hepatoprotective benefits but with different mechanisms and potency. TUDCA generally demonstrates superior bioavailability, stability, and therapeutic potency, particularly for severe liver conditions and endoplasmic reticulum stress. While TUDCA offers broader benefits beyond liver support, including neurological and metabolic advantages, it comes at a significantly higher price point. Milk Thistle provides a more affordable, well-established option with a long history of use and excellent safety profile, making it suitable for general liver maintenance and support. The choice between these supplements depends on specific health needs, budget considerations, and targeted therapeutic goals.
| Feature | TUDCA | Milk Thistle (Silymarin) |
|---|---|---|
| CAS Number | 14605-22-2 | 22888-70-6 (Silymarin) |
| Other Names | Tauroursodeoxycholic Acid, tauroursodeoxycholate, TUDC | Silybum marianum, Holy thistle, Marian thistle, Silymarin |
| Molecular Formula | C₂₆H₄₅NO₆S | C₂₅H₂₂O₁₀ (Silymarin) |
| Molecular Weight | 499.7 g/mol | 482.4 g/mol (Silymarin) |
| Appearance | White to off-white crystalline powder | Yellow to brown powder (extract) |
| Typical Purity | 99% | 80% (standardized extract) |
| Bioavailability | 60-70% (oral) | 23-47% (oral) |
| Potency | High (effective at lower doses) | Moderate (requires higher doses) |
| Half-life | 1-3 hours | 6-8 hours |
| Stability | Highly stable | Moderately stable |
| Popularity | Growing rapidly in supplement industry | Well-established, traditional herb |
| Main Benefits | Liver protection, ER stress reduction, neuroprotection, metabolic support | Liver protection, antioxidant, anti-inflammatory |
| Mechanism of Action | Replaces toxic bile acids, reduces ER stress, prevents apoptosis | Antioxidant activity, cell membrane stabilization |
| Clinical Research | Emerging strong evidence for multiple conditions | Extensive research history, moderate evidence |
| Safety Profile | Very good, limited side effects | Excellent, centuries of safe use |
| Regulatory Status | Supplement in US, drug in some countries | Generally recognized as safe (GRAS) |
| Origin | Synthesized, naturally found in bear bile | Plant-derived (Milk Thistle seeds) |
TUDCA COA
The Certificate of Analysis for ProVita Biotech’s premium TUDCA powder (Tauroursodeoxycholic acid) demonstrates exceptional quality with an impressive assay purity of 99.6%, exceeding the ≥98% standard requirement. Heavy metal content measures below 20ppm, well within safety parameters, while all residual solvents including acetone and ethyl acetate are confirmed below the 0.5% threshold, earning a PASS rating on all safety metrics. Additional tests confirm minimal related compounds with taurine, ursodeoxycholic acid, taurochenodeoxycholic acid, and other impurities all within acceptable limits. This rigorous third-party verification confirms that ProVita Biotech’s TUDCA powder meets international quality standards. This reflects the company’s unwavering commitment to providing supplement manufacturers and distributors with pharmaceutical-grade ingredients, prioritizing consumer safety and product integrity.
Application
Liver Health Support
TUDCA is primarily recognized for its powerful liver-protective properties. It enhances bile flow and prevents cholestasis (bile flow obstruction), making it essential for individuals with fatty liver disease, elevated liver enzymes, or liver damage from toxins or medications. Clinical research demonstrates TUDCA’s ability to reduce liver inflammation, decrease fat accumulation in liver cells, and support healthy liver enzyme function, ultimately helping prevent progression to more serious conditions like cirrhosis and liver failure.
Brain Health
TUDCA shows remarkable neuroprotective benefits against neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Huntington’s. Its effectiveness stems from reducing endoplasmic reticulum (ER) stress and preventing neuronal cell death (apoptosis). TUDCA acts as a chemical chaperone that helps maintain proper protein folding in brain cells, reducing the accumulation of toxic protein aggregates characteristic of these conditions. Research indicates TUDCA can cross the blood-brain barrier, directly supporting neuronal survival and protecting against oxidative damage in the central nervous system.
Metabolic Health
TUDCA significantly improves metabolic function, particularly insulin sensitivity. Clinical studies show it can enhance insulin responsiveness by approximately 30% in insulin-resistant individuals. This bile acid helps regulate glucose metabolism by reducing cellular stress and inflammation in metabolic tissues like muscle, liver, and fat cells. TUDCA’s ability to improve carbohydrate metabolism and enhance cellular energy production makes it valuable for individuals with metabolic disorders, obesity, or pre-diabetic conditions, potentially serving as an adjunct therapy for blood sugar management and metabolic syndrome.
TUDCA Powder Manufacturing Process
Raw Material Acquisition and Initial Processing
• Source pharmaceutical-grade ursodeoxycholic acid (UDCA) as the primary precursor
• Perform rigorous quality testing on all incoming raw materials
• Verify UDCA meets stringent purity specifications before production
Conjugation Reaction
• Combine UDCA with ethyl acetate, ethyl chloroformate, and triethylamine for esterification
• Add sodium hydroxide and taurine to perform the aminolysis reaction
• Monitor reaction parameters (temperature, pH, catalyst concentrations) for optimal yield
Initial Purification
• Filter the reaction mixture to remove solid impurities
• Wash the filtrate with ethyl acetate to remove unreacted materials
• Stratify the mixture to separate phases
Advanced Purification
• Collect and process the water layer containing TUDCA
• Adjust pH using concentrated hydrochloric acid to optimize crystallization
• Filter the solution to obtain crude TUDCA
• Wash crude product with diluted hydrochloric acid to remove inorganic impurities
Final Purification
• Wash the product with acetone to remove organic contaminants
• Filter the mixture in a Class C clean area to maintain pharmaceutical standards
• Collect the wet product for final processing
Drying and Milling
• Dry the purified TUDCA crystals under controlled conditions to remove residual moisture
• Mill the dried product to achieve uniform particle size distribution
• Verify complete removal of all residual solvents
Quality Control and Analysis
• Test each batch using HPLC, infrared, and TLC identification methods
• Verify ≥99% purity level (actual: 99.6%)
• Confirm heavy metals are below 20ppm threshold
• Ensure residual solvents (acetone, ethyl acetate) are below 0.5%
• Validate product meets all specification requirements for pharmaceutical use
Final Processing and Packaging
• Package the verified TUDCA powder in pharmaceutical-grade 25kg containers
• Label with batch information, manufacturing date, and expiration date
• Issue Certificate of Analysis documenting all quality parameters
• Store in well-closed containers protected from light
This meticulous process ensures ProVita Biotech’s TUDCA powder consistently meets international quality standards and passes rigorous third-party testing, providing supplement manufacturers with a pharmaceutical-grade ingredient of exceptional purity and efficacy.
TUDCA Benefits
Liver Health
- Protects liver cells from bile acid-induced damage and apoptosis
- Reduces markers of liver injury (ALT, AST) in various hepatic conditions
- Supports liver regeneration and cellular repair mechanisms
- Fights fatty liver disease by improving fat metabolism
- Helps maintain healthy bile flow and prevents cholestasis
Digestive System
- Enhances bile acid composition for better fat digestion
- Reduces intestinal inflammation and improves gut barrier function
- Supports healthy gut microbiome balance
- Alleviates symptoms in inflammatory bowel conditions
- Helps reduce gallstone formation risk
Cellular Protection
- Combats endoplasmic reticulum (ER) stress throughout the body
- Acts as a powerful chemical chaperone to prevent protein misfolding
- Reduces oxidative stress damage to cellular components
- Protects mitochondrial function and energy production
- Inhibits cell death pathways activated by various stressors
Metabolic Health
- Improves insulin sensitivity and glucose metabolism
- Helps regulate cholesterol levels and lipid profiles
- Supports weight management by enhancing fat metabolism
- Reduces metabolic inflammation markers
- May help prevent complications of metabolic syndrome
Neurological Support
- Provides neuroprotective effects against various neurological conditions
- Crosses blood-brain barrier to support brain cell function
- Reduces neuroinflammation and oxidative stress in neural tissue
- Supports cognitive function and memory preservation
- Shows promise for neurodegenerative disease management
Other Emerging Benefits
- Supports eye health and retinal function
- Enhances athletic performance and exercise recovery
- Promotes healthy aging through cellular protection mechanisms
- Supports kidney function and protects against nephrotoxicity
- Shows potential in supporting fertility and reproductive health
Where to buy TUDCA bulk powder?
At ProVita Biotech, we specialize in manufacturing and supplying premium TUDCA bulk powder at competitive prices. As China’s leading TUDCA producer, we guarantee:
- 99% pure pharmaceutical-grade TUDCA bulk powder with COA verification
- Minimum order quantities starting at 1kg with bulk discounts available
- Free samples for quality verification before purchase
- ISO-certified manufacturing facilities with strict quality control
- Complete documentation including MSDS, COA, and regulatory compliance papers
- Fast processing times and reliable global shipping options
- Custom packaging solutions for different business needs
- Stable supply chain with consistent pricing and availability
Why Choose ProVita for Your TUDCA Bulk Powder Needs
Our TUDCA bulk powder undergoes rigorous testing to ensure the highest purity and potency. We serve supplement manufacturers, pharmaceutical companies, research institutions, and health product formulators worldwide with our superior tauroursodeoxycholic acid powder.
Contact our sales team today for current TUDCA bulk powder pricing, technical specifications, or to request a free sample. ProVita Biotech – your trusted partner for premium TUDCA powder direct from our China factory.
FAQs
Tauroursodeoxycholic acid (TUDCA) primarily supports liver health by reducing cellular stress, protecting hepatocytes from damage, enhancing bile flow, and supporting detoxification pathways. Beyond liver support, it provides benefits for digestive health, metabolic function, and neurological protection.
TUDCA is the taurine-conjugated form of UDCA (ursodeoxycholic acid). This conjugation improves water solubility, bioavailability, and cell membrane penetration, making TUDCA more effective at lower doses compared to UDCA, particularly for certain applications requiring enhanced cellular absorption.
While ox bile contains multiple bile acids in varying concentrations, TUDCA is a specific, isolated bile acid that's been purified to 99% concentration. This isolation allows for precise dosing and targeted therapeutic effects that broad-spectrum ox bile supplements cannot provide.
TUDCA and N-acetylcysteine (NAC) work through complementary mechanisms. While NAC primarily supports glutathione production and antioxidant defense, TUDCA focuses on bile acid regulation, endoplasmic reticulum stress reduction, and cell membrane protection. Many formulators combine both for comprehensive liver support.
Though they sound similar, they're distinct compounds. Taurine is an amino acid used in bile acid conjugation, while TUDCA is a complete bile acid already conjugated with taurine. TUDCA has more specific therapeutic applications and stronger hepatoprotective effects compared to taurine alone.
ProVita Biotech produces TUDCA through advanced chemical synthesis rather than animal extraction. Our synthesis process follows pharmaceutical standards to ensure the highest purity and consistency while maintaining ethical production practices.
ProVita's TUDCA is manufactured in ISO 9001:2015 and GMP-certified facilities. Each batch comes with comprehensive documentation including Certificate of Analysis (COA), HPLC chromatograms, heavy metal testing, and microbial analysis reports.
Common ingredients paired with TUDCA in advanced liver formulations include Milk Thistle (silymarin), NAC, ALA (Alpha Lipoic Acid), Choline, Artichoke Extract, Dandelion Root, and Methionine. These create synergistic effects for comprehensive hepatic support.
Yes, our TUDCA maintains stability in various formulation environments. It performs well in capsules, tablets, powders, and certain liquid suspensions. We can provide stability data for different pH levels, temperature conditions, and storage parameters.
Yes, ProVita offers comprehensive OEM/ODM services including custom formulation, packaging design, and finished product manufacturing for TUDCA-containing supplements. We can produce capsules, tablets, powders, and blends according to your specifications.
Bulk pricing varies based on quantity, purity specifications, and current market conditions. Don't hesitate to get in touch with our sales team for a customized quotation based on your requirements. We offer competitive pricing with transparency regarding volume discounts.
Yes, we offer complimentary samples (typically 10-25g) of our TUDCA powder for quality evaluation prior to bulk ordering. Samples include specification documents and are subject only to shipping charges.