Uridine 5'-monophosphate Disodium Salt Powder
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What is Uridine 5'-monophosphate Disodium Salt?
Uridine 5′-monophosphate Disodium Salt (CAS 3387-36-8), also known as Disodium Uridine 5′-monophosphate, UMP Disodium, or Sodium Uridylate, is a nucleotide composed of uridine with a phosphate group attached to the 5′ position of its ribose ring and neutralized with two sodium ions. It has a molecular formula of C9H11N2Na2O9P and a molecular weight of 368.15 g/mol. This compound is commonly found in breast milk and various foods like mushrooms, brewer’s yeast, and organ meats, and is available commercially as a white to off-white crystalline powder with 99% purity specifications. UMP Disodium Salt exhibits good bioavailability when taken orally and is frequently used in nutritional supplements for cognitive support, as a food additive (E627), and in pharmaceutical applications. Provita Biotech stands as the leading bulk Uridine 5′-monophosphate Disodium Salt powder supplier in China, providing high-quality material for global distribution in the nutritional, pharmaceutical, and food industries.
Uridine 5'-monophosphate Disodium Salt VS Uridine monophosphate
Uridine 5′-monophosphate Disodium Salt is generally superior to free-form Uridine Monophosphate for commercial and supplemental applications. The disodium salt form offers better stability, water solubility, and bioavailability, making it the preferred choice for nutritional supplements, pharmaceutical formulations, and food applications. Its improved shelf life and consistency in manufacturing also contribute to its wider commercial adoption. While the disodium salt form is typically more expensive, its enhanced properties justify the cost difference for most applications. For consumers seeking uridine supplementation, the disodium salt form provides better absorption and efficacy, making it the optimal choice among UMP variations.
Forms of Uridine Monophosphate (UMP)
Uridine monophosphate exists in several forms:
- Free acid form (Uridine monophosphate) – less stable, less soluble
- Disodium salt (Uridine 5′-monophosphate Disodium Salt) – most common commercial form
- Monosodium salt – less common intermediate form
- Potassium salt – specialized applications
- Choline salt – used in some nutraceutical formulations
The disodium salt form is considered the best overall choice for most applications due to its stability, solubility, and bioavailability profile.
| Property | Uridine 5′-monophosphate Disodium Salt | Uridine Monophosphate (free acid) |
|---|---|---|
| CAS Number | 3387-36-8 | 58-97-9 |
| Other Names | Disodium Uridylate, UMP Disodium, Sodium Uridine 5′-monophosphate | Uridylic Acid, 5′-UMP, Uridine 5′-phosphoric acid |
| Molecular Formula | C₉H₁₁N₂Na₂O₉P | C₉H₁₃N₂O₉P |
| Molecular Weight | 368.15 g/mol | 324.18 g/mol |
| Appearance | White to off-white crystalline powder | White crystalline powder |
| Purity | Typically available at 99% or higher | Typically 98-99% |
| Bioavailability | Higher; better absorption due to improved water solubility | Lower; less soluble in water |
| Potency | Higher effective potency due to better absorption | Lower effective potency despite similar molecular basis |
| Half-life | Similar base half-life, but better sustained plasma levels | Similar base half-life |
| Stability | More stable in various formulations and storage conditions | Less stable, more susceptible to degradation |
| pH in solution | Approximately 7.0-8.5 (more neutral) | Acidic (approximately 4-5) |
| Water Solubility | High (~50g/100mL at 25°C) | Low (sparingly soluble) |
| Popularity | More widely used in supplements and food additives | Less common in commercial applications |
| Pricing | 15-25% higher cost | Lower cost, but less commercially viable |
| Main Benefits | Cognitive support, RNA synthesis, cell membrane formation, enhanced food flavor | Same biological functions but less practical for formulations |
| Commercial Use | Widely used in supplements, infant formula, and as flavor enhancer (E627) | Limited commercial applications |
| Manufacturing | Easier to process in industrial applications | More challenging to incorporate into formulations |
| Hygroscopicity | Less hygroscopic | More hygroscopic |
| Thermal Stability | More thermally stable | Less thermally stable |
| Regulatory Status | Widely approved as food additive (E627) | Less commonly regulated specifically |
Uridine 5'-monophosphate Disodium Salt COA
ProVita Biotech’s Uridine 5′-monophosphate Disodium Salt (UMP) powder demonstrates exceptional quality with 99.2% assay purity, substantially exceeding the 98.0-102.0% specification requirement. This premium nucleotide powder exhibits minimal heavy metal content with Lead (Pb) at <0.5ppm, Arsenic (As) at <0.5ppm, Cadmium (Cd) at <0.3ppm, and Mercury (Hg) at <0.1ppm—all well below international safety thresholds. Residual solvent analysis confirms ethanol levels at <1000ppm and methanol at <300ppm, complying with USP<467> guidelines for pharmaceutical-grade supplements. ProVita Biotech’s UMP Disodium Salt (CAS 3387-36-8) has undergone rigorous third-party laboratory testing to ensure consistent molecular integrity and bioavailability for cognitive health applications. Our dedication to quality control and safety standards makes this pyrimidine nucleotide an ideal choice for supplement manufacturers and distributors seeking premium ingredients that meet or exceed cGMP, USP, and international regulatory requirements for nutraceutical formulations.
Application
Cognitive Health Supplements
Uridine 5′-monophosphate Disodium Salt is a key ingredient in nootropic and cognitive enhancement supplements. This compound crosses the blood-brain barrier and supports phosphatidylcholine synthesis, which is crucial for neuron membrane formation and repair. Scientific research suggests UMP Disodium Salt may improve memory, learning capacity, and overall cognitive function when combined with other nutrients like DHA and choline. Many premium brain health supplements include this ingredient to promote neuroplasticity and support long-term brain health, making it increasingly popular in the growing cognitive enhancement market.
Infant Formula Fortification
As a naturally occurring component in breast milk, Uridine 5′-monophosphate Disodium Salt is a vital ingredient in premium infant formulas. This nucleotide plays an essential role in rapid cellular development, immune system maturation, and brain development in newborns and infants. Studies show that UMP-fortified formulas help bring commercially prepared infant nutrition closer to the gold standard of breast milk. Leading infant formula manufacturers add precise amounts of UMP Disodium Salt to support optimal growth and development, particularly focusing on cognitive and immune system benefits during this critical developmental window.
Food Flavor Enhancement (E627)
Known in the food industry as E627, Uridine 5′-monophosphate Disodium Salt serves as a potent flavor enhancer that amplifies savory (umami) tastes in processed foods. This nucleotide works synergistically with other flavor enhancers like monosodium glutamate (MSG) and guanosine monophosphate (GMP), allowing manufacturers to reduce sodium content while maintaining desirable taste profiles. The compound is commonly used in soups, broths, savory snacks, meat products, and ready-to-eat meals. Food manufacturers value UMP Disodium Salt for its ability to create richer flavor experiences at low concentrations, making it an economical and effective ingredient in commercial food production.
Uridine 5'-monophosphate Disodium Salt Powder Manufacturing Process
Raw Material Preparation and Quality Control
The process begins with the careful selection of high-grade cytidine monophosphate (CMP) and sodium nitrite as primary raw materials. Each batch undergoes thorough quality inspection to ensure purity and consistency before entering production. All raw materials are tested for contaminants and accompanied by certificates of analysis.
Diazotization Reaction
In the core manufacturing step, CMP undergoes a controlled diazotization process where it is mixed with sodium nitrite in a temperature-regulated reactor. A precise amount of acid is gradually added to facilitate the conversion of the amino group in CMP to UMP. The reaction parameters, including temperature (maintained at 0-5°C), pH, and reaction time (4-6 hours), are carefully monitored to maximize yield and prevent formation of impurities.
Neutralization and Salt Formation
Following the diazotization reaction, the solution undergoes neutralization with sodium hydroxide to achieve the optimal pH (7.0-7.5), forming the disodium salt. This step requires precise control to ensure complete conversion to the disodium form while preventing degradation of the nucleotide structure.
Purification Process
The crude UMP-Na₂ solution undergoes a multi-stage purification process:
- Initial filtration to remove particulate matter
- Ion-exchange chromatography to eliminate ionic impurities
- Activated carbon treatment to remove colored impurities and organic contaminants
- Ultra-filtration through specialized membranes to achieve high purity
Crystallization and Isolation
The purified solution undergoes controlled crystallization under specific temperature and concentration conditions. The resulting crystals are separated through centrifugation and collected as pure UMP-Na₂.
Drying and Milling
The wet UMP-Na₂ crystals undergo a specialized spray drying process at controlled temperatures to prevent thermal degradation. The dried product is then finely milled to achieve uniform particle size and optimal flow characteristics for the final powder.
Uridine 5'-monophosphate Disodium Salt Benefits
- Enhanced Cognitive Function – Supports memory formation, learning capacity, and overall brain health by promoting synapse formation.
- Neurotransmitter Synthesis – Aids in the production of acetylcholine and other crucial brain chemicals that regulate mood and cognition.
- Improved Cell Membrane Structure – Contributes to phosphatidylcholine synthesis, strengthening neuronal cell membranes and function.
- Infant Development Support – Naturally present in breast milk, helps in healthy brain and immune system development in infants.
- RNA/DNA Synthesis – Essential building block for nucleic acid production, supporting cellular growth and renewal.
- Dopamine Receptor Upregulation – May help normalize dopamine receptor density, supporting balanced mood and motivation.
- Enhanced Food Flavor – Acts as a flavor enhancer (E627) that amplifies umami taste in food products.
- Mitochondrial Function – Supports cellular energy production by enhancing mitochondrial function and efficiency.
- Phospholipid Synthesis – Critical for the production of phospholipids that maintain cellular structure throughout the body.
- Superior Bioavailability – The disodium salt form offers enhanced absorption compared to other uridine forms.
Where to buy Uridine 5'-monophosphate Disodium bulk powder?
ProVita Biotech stands as China’s premier supplier of high-quality Uridine 5′-monophosphate Disodium Salt bulk powder. With over 15 years of specialized experience in nucleotide manufacturing, we deliver pharmaceutical-grade UMP Disodium Salt (CAS 3387-36-8) at competitive wholesale prices.
Our Uridine 5′-monophosphate Disodium Salt bulk powder is manufactured in ISO-certified facilities and undergoes rigorous quality testing to ensure 99% purity, batch consistency, and compliance with international standards. Each shipment includes comprehensive certificates of analysis and meets strict regulatory requirements for global distribution.
ProVita Biotech offers flexible packaging options from 1kg sample sizes to multi-ton bulk orders of Uridine 5′-monophosphate Disodium Salt powder with quick turnaround times and reliable shipping to over 50 countries. Our technical specialists provide expert formulation support and documentation to streamline your product development process.
Contact our sales team today for Uridine 5′-monophosphate Disodium Salt bulk pricing, detailed specifications, and custom manufacturing options. Experience why leading supplement manufacturers, food producers, and pharmaceutical companies worldwide trust ProVita Biotech as their preferred Uridine 5′-monophosphate Disodium Salt supplier.
FAQs
At ProVita Biotech, we recommend combining Uridine 5'-monophosphate Disodium Salt with choline sources (Alpha-GPC or CDP-Choline), DHA, B vitamins (particularly B12 and folate), and phosphatidylserine for synergistic cognitive enhancement effects. This combination supports the Kennedy Pathway for phospholipid synthesis and maximizes neuronal membrane formation. Many of our clients have achieved market-leading nootropic products using this science-backed stack.
Our standard MOQ for UMP Disodium is 1kg for first-time customers. For established partners, we can accommodate sample sizes of 100-500g for R&D and testing purposes. Volume discounts begin at 5kg, with significant price advantages at 25kg and above. We structure our MOQs to support both emerging brands and established manufacturers.
ProVita Biotech's UMP Disodium Salt is manufactured in our ISO 9001:2015 and ISO 22000:2018 certified facilities. Each batch receives a comprehensive Certificate of Analysis and complies with USP/EP standards. We maintain Kosher and Halal certifications, and our material is suitable for both food (E627) and supplement applications. Our quality documentation package facilitates smooth regulatory submission in your target markets.
We package bulk Uridine 5'-monophosphate Disodium in food-grade, double-lined aluminum foil bags within secure fiber drums to ensure stability during transit. Each 25kg drum is properly sealed, labeled according to international shipping regulations, and accompanied by complete documentation. For temperature-sensitive destinations, we offer climate-controlled shipping options to maintain product integrity.
Standard lead time for UMP Disodium Salt is 2-3 weeks for quantities up to 100kg and 3-4 weeks for larger orders. We maintain regular inventory of our highest-purity material to accommodate urgent requests, with expedited production available for qualified partners. Our production scheduling is designed to support your manufacturing timelines with reliable delivery windows.
Yes, ProVita Biotech offers custom blending, granulation, and pre-mixing services for Disodium Uridylate with complementary ingredients. Our R&D team can develop proprietary ratios of nucleotides or specialized formulations tailored to your product specifications. We also provide white-label and OEM services with complete formulation support from concept to finished product.
Our Uridine 5'-monophosphate Disodium exhibits excellent stability with a shelf life of 24 months when stored in original packaging under recommended conditions (<25°C, low humidity). We provide accelerated and real-time stability data as part of our technical documentation package. The disodium salt form demonstrates superior stability compared to the free acid form, particularly in solution and various pH environments.
ProVita Biotech offers UMP Disodium in 98%, 99%, and 99.5% purity grades. Our standard 99% purity is suitable for most supplement and food applications, while pharmaceutical applications often require 99.5% purity, which commands a 15-20% premium. The 98% grade is available for cost-sensitive applications with approximately 10-15% savings compared to our standard grade.
We employ HPLC, UV spectroscopy, and NMR for comprehensive purity analysis of our Uridine 5'-monophosphate Disodium Salt. Each batch undergoes testing for impurity profiles, heavy metals, microbial limits, and residual solvents. Our in-house and third-party testing protocols exceed industry standards, ensuring consistent quality with detailed documentation of analytical methods and results.
Yes, we can provide customized particle size distributions of UMP Disodium to meet your specific manufacturing requirements. Our standard material has a mean particle size of 80-120 microns, but we can adjust granulation for direct compression applications, beverages, or specialized delivery systems. This customization improves flowability, reduces clumping, and enhances dissolution rates in your final formulations.